Cationic liposomes as carriers for aerosolized formulations of an anionic drug: Safety and efficacy study

European Journal of Pharmaceutical Sciences

Volumn 38, Issue 2, 2009, Pages 165-171

  Bai, Shuhua ^a   Gupta, Vivek ^a   Ahsan, Fakhrul ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Cationic liposome; Jugular vein thrombosis; Low molecular weight heparin; Lung toxicity; Pulmonary delivery; Pulmonary embolism

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; CHOLESTEROL; LIPOSOME; LOW MOLECULAR WEIGHT HEPARIN; MACROGOL 2000;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD CLOT LYSIS; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG ELIMINATION; DRUG FORMULATION; DRUG SAFETY; ENDOCYTOSIS; HALF LIFE TIME; HISTOPATHOLOGY; LIPOSOMAL DELIVERY; LUNG EMBOLISM; LUNG TOXICITY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SURFACE CHARGE;

AEROSOLS; ANIMALS; ANIONS; ANTICOAGULANTS; BIOLOGICAL AVAILABILITY; BRONCHOALVEOLAR LAVAGE FLUID; CATIONS; CHEMISTRY, PHARMACEUTICAL; HEPARIN, LOW-MOLECULAR-WEIGHT; LIPOSOMES; LUNG; MALE; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; THROMBOSIS;

EID: 68749119666     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2009.07.002     Document Type: Article

References (25)

1. Audouy S.A., de Leij L.F., Hoekstra D., and Molema G. In vivo characteristics of cationic liposomes as delivery vectors for gene therapy. Pharm. Res. 19 (2002) 1599-1605
2. Bai S., Thomas C., and Ahsan F. Dendrimers as a carrier for pulmonary delivery of enoxaparin, a low-molecular weight heparin. J. Pharm. Sci. 96 (2007) 2090-2106
3. Bai S., and Ahsan F. Synthesis and evaluation of pegylated dendrimeric nanocarrier for pulmonary delivery of low molecular weight heparin. Pharm. Res. 26 (2009) 539-548
4. Bradley A.J., and Devine D.V. The complement system in liposome clearance: can complement deposition be inhibited?. Adv. Drug Deliv. Rev. 32 (1998) 19-29
5. Darien B.J., Saban M.R., Hart A.P., MacWilliams P.S., Clayton M.K., and Kruse-Elliott K.T. Morphometric analysis of oleic acid-induced permeability pulmonary edema: correlation with gravimetric lung water. Shock (Augusta, GA) 8 (1997) 61-67
6. Gabizon A., and Papahadjopoulos D. Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors. Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 6949-6953
7. Hafez I.M., Ansell S., and Cullis P.R. Tunable pH-sensitive liposomes composed of mixtures of cationic and anionic lipids. Biophys. J. 79 (2000) 1438-1446
8. Harashima H., Sakata K., Funato K., and Kiwada H. Enhanced hepatic uptake of liposomes through complement activation depending on the size of liposomes. Pharm. Res. 11 (1994) 402-406
9. Heeremans J.L., Gerritsen H.R., Meusen S.P., Mijnheer F.W., Gangaram Panday R.S., Prevost R., Kluft C., and Crommelin D.J. The preparation of tissue-type plasminogen activator (t-PA) containing liposomes: entrapment efficiency and ultracentrifugation damage. J. Drug Target. 3 (1995) 301-310
10. Hickey A.J., and Garcia-Contreras L. Immunological and toxicological implications of short-term studies in animals of pharmaceutical aerosol delivery to the lungs: relevance to humans. Crit. Rev. Ther. Drug Carrier Syst. 18 (2001) 387-431
11. Lv H., Zhang S., Wang B., Cui S., and Yan J. Toxicity of cationic lipids and cationic polymers in gene delivery. J. Control. Release 114 (2006) 100-109
12. Mustafa F., Yang T., Khan M.A., and Ahsan F. Chain length-dependent effects of alkylmaltosides on nasal absorption of enoxaparin. J. Pharm. Sci. 93 (2004) 675-683
13. Pedroso de Lima M.C., Simoes S., Pires P., Faneca H., and Duzgunes N. Cationic lipid-DNA complexes in gene delivery: from biophysics to biological applications. Adv. Drug Deliv. Rev. 47 (2001) 277-294
14. Qi Y., Zhao G., Liu D., Shriver Z., Sundaram M., Sengupta S., Venkataraman G., Langer R., and Sasisekharan R. Delivery of therapeutic levels of heparin and low-molecular-weight heparin through a pulmonary route. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 9867-9872
15. Segal J.B., Eng J., Tamariz L.J., and Bass E.B. Review of the evidence on diagnosis of deep venous thrombosis and pulmonary embolism. Ann. Fam. Med. 5 (2007) 63-73
16. Song Y.K., and Kim C.K. Topical delivery of low-molecular-weight heparin with surface-charged flexible liposomes. Biomaterials 27 (2006) 271-280
17. Stassen J.M., Lijnen H.R., Kieckens L., and Collen D. Small animal thrombosis models for the evaluation of thrombolytic agents. Circulation 83 (1991) IV65-72
18. Szoka Jr. F., and Papahadjopoulos D. Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proc. Natl. Acad. Sci. U.S.A. 75 (1978) 4194-4198
19. Weitz J.I. Low-molecular-weight heparins. N. Engl. J. Med. 337 (1997) 688-698
20. Woodle M.C., and Lasic D.D. Sterically stabilized liposomes. Biochim. Biophys. Acta 1113 (1992) 171-199
21. Yan X., Scherphof G.L., and Kamps J.A. Liposome opsonization. J. Liposome Res. 15 (2005) 109-139
22. Yang T., Arnold J.J., and Ahsan F. Tetradecylmaltoside (TDM) enhances in vitro and in vivo intestinal absorption of enoxaparin, a low molecular weight heparin. J. Drug Target. 13 (2005) 29-38
23. Yang T., Hussain A., Bai S., Khalil I.A., Harashima H., and Ahsan F. Positively charged polyethylenimines enhance nasal absorption of the negatively charged drug, low molecular weight heparin. J. Control. Release 115 (2006) 289-297
24. Yang T., Mustafa F., and Ahsan F. Alkanoylsucroses in nasal delivery of low molecular weight heparins: in-vivo absorption and reversibility studies in rats. J. Pharm. Pharmcacol. 56 (2004) 53-60
25. Yang T., Mustafa F., Bai S., and Ahsan F. Pulmonary delivery of low molecular weight heparins. Pharm. Res. 21 (2004) 2009-2016