Genetic variation in the G72 (DAOA) gene affects temporal lobe and amygdala structure in subjects affected by bipolar disorder

Bipolar Disorders

Volumn 11, Issue 6, 2009, Pages 621-627

  Zuliani, Riccardo ^a,b   Moorhead, T William J ^b   Job, Dominic ^b   McKirdy, James ^b   Sussmann, Jessika E D ^b   Johnstone, Eve C ^b   Lawrie, Stephen M ^b   Brambilla, Paolo ^a,c   Hall, Jeremy ^b   McIntosh, Andrew M ^b  

^a UNIVERSITY OF UDINE   (Italy)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c SCIENTIFIC INSTITUTE   (Italy)

Author keywords

Bipolar disorder; DAOA; G72; MRI; Voxel based morphometry

Indexed keywords

DEXTRO AMINO ACID OXIDASE; PROTEIN G72; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ADULT; AMYGDALOID NUCLEUS; ARTICLE; BIPOLAR DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC VARIABILITY; GENOTYPE; GRAY MATTER; HUMAN; MALE; PATHOGENESIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TEMPORAL LOBE;

ADULT; AMYGDALA; BIPOLAR DISORDER; CARRIER PROTEINS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; LINKAGE (GENETICS); MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; TEMPORAL LOBE;

EID: 68749117676     PISSN: 13985647     EISSN: 13995618     Source Type: Journal    
DOI: 10.1111/j.1399-5618.2009.00731.x     Document Type: Article

References (43)

1. Merikangas KR, Akiskal HS, Angst J et al. Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry 2007; 64: 543-552.
2. Blumberg HP, Kaufman J, Martin A et al. Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Arch Gen Psychiatry 2003; 60: 1201-1208.
3. Stanfield AC, Moorhead TWJ, Job DE et al. Structural abnormalities of ventrolateral and orbitofrontal cortex in patients with familial bipolar disorder. Bipolar Disord 2009; 11: 135-144.
4. Adler CM, Levine AD, DelBello MP, Strakowski SM. Changes in gray matter volume in patients with bipolar disorder. Biol Psychiatry 2005; 58: 151-157.
5. Wilke M, Kowatch RA, DelBello MP, Mills NP, Holland SK. Voxel-based morphometry in adolescents with bipolar disorder: First results. Psychiatry Res 2004; 131: 57-69.
6. Lochhead RA, Parsey RV, Oquendo MA, Mann JJ. Regional brain gray matter volume differences in patients with bipolar disorder as assessed by optimized voxel-based morphometry. Biol Psychiatry 2004; 55: 1154-1162.
7. Kasai K, Shenton ME, Salisbury DF et al. Differences and similarities in insular and temporal pole MRI gray matter volume abnormalities in first-episode schizophrenia and affective psychosis. Arch Gen Psychiatry 2003; 60: 1069-1077.
8. Barbas H. Flow of information for emotions through temporal and orbitofrontal pathways. J Anat 2007; 211: 237-249.
9. Olson IR, Plotzker A, Ezzyat Y. The enigmatic temporal pole: A review of findings on social and emotional processing. Brain 2007; 130: 1718-1731.
10. Murai T, Fujimoto S. Rapid cycling bipolar disorder after left temporal polar damage. Brain Inj 2003; 17: 355-358.
11. Gruber J, Lemoine JN, Knight RT, Harvey AG. Positive mood and sleep disturbance in acquired mania following temporal lobe damage. Brain Inj 2007; 21: 1209-1215.
12. Carran MA, Kohler CG, O'Connor MJ, Bilker WB, Sperling MR. Mania following temporal lobectomy. Neurology 2003; 61: 770-774.
13. Craddock N, Jones I. Genetics of bipolar disorder. J Med Genet 1999; 36: 585-594.
14. Maier W, Zobel A, Rietschel M. Genetics of schizophrenia and affective disorders. Pharmacopsychiatry 2003; 36: S195-202.
15. Chumakov I, Blumenfeld M, Guerassimenko O et al. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci U S A 2002; 99: 13675-13680.
16. Boks MP, Rietkerk T, van de Beek MH, Sommer IE, de Koning TJ, Kahn RS. Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia. Eur Neuropsychopharmacol 2007; 17: 567-572.
17. Kvajo M, Dhilla A, Swor DE, Karayiorgou M, Gogos JA. Evidence implicating the candidate schizophrenia/bipolar disorder susceptibility gene G72 in mitochondrial function. Mol Psychiatry 2008; 13: 685-696.
18. Kugaya A, Sanacora G. Beyond monoamines: Glutamatergic function in mood disorders. CNS Spectr 2005; 10: 808-819.
19. Stork C, Renshaw PF. Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research. Mol Psychiatry 2005; 10: 900-919.
20. Hall J, Whalley HC, Moorhead TWJ et al. Genetic variation in the DAOA (G72) gene modulates hippocampal function in subjects at high risk of schizophrenia. Biol Psychiatry 2008; 64: 428-433.
21. McGuffin P, Farmer A, Harvey I. A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Arch Gen Psychiatry 1991; 48: 764-770.
22. First MB, Spitzer RL, Miriam G, Williams JBW. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. New York: Biometrics Research, New York State Psychiatric Institute, 2002.
23. Kay SR, Fiszbein A, Opler LA. The positive and negative symptom scale (PANSS) for schizophrenia. Schizophr Bull 1987; 13: 261-276.
24. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56-62.
25. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania; reliability, validity and sensitivity. Br J Psychiatry 1978; 133: 429-435.
26. Shi J, Badner JA, Gershon ES, Liu C. Allelic association of G72/G30 with schizophrenia and bipolar disorder: A comprehensive meta-analysis. Schizophr Res 2008; 98: 89-97.
27. Detera-Wadleigh SD, McMahon FJ. G72/G30 in schizophrenia and bipolar disorder: Review and meta-analysis. Biol Psychiatry 2006; 60: 106-114.
28. Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 2001; 14: 21-36.
29. Nelson HE, Willison JR. National Adult Reading Test Manual (2nd ed). Windsor: NFER-Nelson, 1991.
30. Shenton ME, Dickey CC, Frumin M, McCarley RW. A review of MRI findings in schizophrenia. Schizophr Res 2001; 49: 1-52.
31. DelBello MP, Zimmerman ME, Mills NP, Getz GE, Strakowski SM. Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder. Bipolar Disord 2004; 6: 43-52.
32. Chang K, Karchemskiy A, Barnea-Goraly N, Garrett A, Simeonova DI, Reiss A. Reduced amygdalar gray matter volume in familial pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry 2005; 44: 565-573.
33. Altshuler LL, Bartzokis G, Grieder T, Curran J, Mintz J. Amygdala enlargement in bipolar disorder and hippocampal reduction in schizophrenia: An MRI study demonstrating neuroanatomic specificity. Arch Gen Psychiatry 1998; 55: 663-664.
34. Brambilla P, Harenski K, Nicoletti M et al. MRI investigation of temporal lobe structures in bipolar patients. J Psychiatr Res 2003; 37: 287-295.
35. Chen BK, Sassi R, Axelson D et al. Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorder. Biol Psychiatry 2004; 56: 399-405.
36. Foland LC, Altshuler LL, Sugar CA et al. Increased volume of the amygdala and hippocampus in bipolar patients treated with lithium. Neuroreport 2008; 19: 221-224.
37. Altshuler L, Bookheimer S, Proenza MA et al. Increased amygdala activation during mania: A functional magnetic resonance imaging study. Am J Psychiatry 2005; 162: 1211-1213.
38. Adler CM, Holland SK, Schmithorst V, Tuchfarber MJ, Strakowski SM. Changes in neuronal activation in patients with bipolar disorder during performance of a working memory task. Bipolar Disord 2004; 6: 540-549.
39. Blair RJR, Morris JS, Frith CD, Perrett DI, Dolan RJ. Dissociable neural responses to facial expressions of sadness and anger. Brain 1999; 122: 883-893.
40. Richardson MP, Strange BA, Dolan RJ. Encoding of emotional memories depends on amygdala and hippocampus and their interactions. Nat Neurosci 2004; 7: 278-285.
41. Adolphs R. Social cognition and the human brain. Trends Cogn Sci 1999; 3: 469-479.
42. Williams NM, Green EK, Macgregor S et al. Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder. Arch Gen Psychiatry 2006; 63: 366-373.
43. Goldberg TE, Straub RE, Callicott JH et al. The G72/G30 gene complex and cognitive abnormalities in schizophrenia. Neuropsychopharmacology 2006; 31: 2022-2032.