Prednisone reduces ketoconazole-induced skeletal defects in rat fetuses

Archives of Toxicology

Volumn 83, Issue 9, 2009, Pages 863-871

  Amaral, Vanessa Cristiane Santana ^a,b   Nunes Jr , Guilhermino Pereira ^a  

^a FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^b UNIVERSIDADE ESTADUAL DE GOIÁS   (Brazil)

Author keywords

Embryotoxicity; Ketoconazole; Maternal toxicity; Prednisone; Skeletal anomalies

Indexed keywords

KETOCONAZOLE; PREDNISONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CLEFT PALATE; CONTROLLED STUDY; EMBRYOTOXICITY; FEMALE; FETUS; GESTATION PERIOD; NONHUMAN; ORGANOGENESIS; PREGNANCY; PRIORITY JOURNAL; RAT; REPRODUCTION; SKELETON MALFORMATION; STEROIDOGENESIS; TERATOGENESIS;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; BONE AND BONES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; DRUG COMBINATIONS; DRUG TOXICITY; EATING; EMBRYO, MAMMALIAN; FEMALE; GLUCOCORTICOIDS; KETOCONAZOLE; MATERNAL EXPOSURE; PREDNISONE; PREGNANCY; RANDOM ALLOCATION; RATS; RATS, WISTAR; TERATOGENS; TIME FACTORS; WEIGHT GAIN;

MAMMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 68749100629     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-009-0439-6     Document Type: Article

References (25)

1. AHFS (1998) American Hospital Formulary Service. Drug Information. McEvoy GK (ed) USA, pp 96-119
2. VCS Amaral GP Nunes Jr 2008 Ketoconazole-and fluconazole-induced embryotoxicity and skeletal anomalies in Wistar rats: a comparative study Braz Arch Biol Technol 51 1153 1161
3. Briggs GG, Freeman RK, Yaffe SJ (1998) Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk. Lippincott Williams & Wilkins, USA
4. HS Buttar JH Moffatt C Bura 1989 Pregnancy outcome in ketoconazole-treated rats and mice Teratology 39 444
5. JA Como WE Dismukes 1994 Drug therapy: oral azole drugs as systemic antifungal therapy N Engl J Med 330 263 272 10.1056/NEJM199401273300407 (Pubitemid 24034139)
6. AM Cummings JL Hedge J Laskey 1997 Ketoconazole impairs early pregnancy and decidual cell response via alterations in ovarian function Fundam Appl Toxicol 40 238 246 10.1006/faat.1997.2392 (Pubitemid 28046472)
7. D Engelhardt MM Weber T Miksch F Abedinpour C Jaspers 1991 The influence of ketoconazole on human adrenal steroidogenesis-incubation studies with tissue-slices Clin Endocrinol (Oxf) 35 163 168 10.1111/j.1365-2265.1991.tb03516. x
8. Friedman JM, Polifka JE (1996) The effect of drugs on the fetus and nursing infant. Johns Hopins University Press, Baltimore
9. A Iranmanesh RM Ovetsky G Lizarralde CJ Schleupner 1987 Effect of ketoconazole on the 11-hydroxylation step of adrenal steroidogenesis South Med J 80 725 728 10.1097/00007611-198706000-00015 (Pubitemid 18010706)
10. Z Kazy E Puhó AE Czeizel 2005 Population-based case-control study of oral ketoconazole: treatment for birth outcomes Congenit Anom (Kyoto) 45 5 8 10.1111/j.1741-4520.2005.00053.x (Pubitemid 41657747)
11. CA Kimmel JG Wilson 1973 Skeletal deviations in rats: malformations or variations? Teratology 8 309 316 10.1002/tera.1420080311
12. CT King PD Rogers JD Cleary SW Chapman 1998 Antifungal therapy during pregnancy Clin Infect Dis 27 1151 1160 10.1086/514977
13. DS Loose PB Kan MA Hirst RA Marcus D Feldman 1983 Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes J Clin Invest 71 1495 1499 10.1172/JCI110903
14. GJ MacDonald 1978 Factors involved in maintenance of pregnancy in the rat. The temporal need for estrogen, pituitary prolactin and the ovary Biol Reprod 19 817 823 10.1095/biolreprod19.4.817
15. Manson JM, Zenick H, Costlow RD (1982) Teratology test methods for laboratory animals. In: Hayves AW (ed) Principles of toxicology. Wallace Hayes, New York, pp 141-184
16. VV Moudgal JD Sobel 2003 Antifungal drugs in pregnancy: a review Expert Opin Drug Saf 2 457 483 10.1517/14740338.2.5.475
17. RJ Rodriguez D Acosta Jr 1995 Comparison of ketoconazole and fluconazole induced hepatotoxicity in a primary culture system of rat hepatocytes Toxicology 96 83 92 10.1016/0300-483X(94)02911-D
18. DJ Sheehan CA Hitchcock CM Sibley 1999 Current and emerging azole antifungal agents Clin Microbiol Rev 12 40 79
19. JD Sobel 2000 Use of antifungal drugs in pregnancy: a focus on safety Drug Saf 23 77 85 10.2165/00002018-200023010-00005
20. N Sonino 1987 The use of ketoconazole as an inhibitor of steroid production N Engl J Med 317 812 818
21. H Van Cauteren A Lampo J Vandenberghe 1989 Toxicological profile and safety evaluation of antifungal azole derivates Mycoses 32 60 66
22. H Van Cauteren A Lampo J Vandenberghe 1990 Safety aspects of oral antifungal agents Br J Clin Pract Suppl 71 47 49
23. H Vanden Bossche 1985 Biochemical targets for antifungal azole derivates: hypothesis on the mode of action Curr Top Med Mycol 1 313 351
24. H Vanden Bossche 1992 Inhibitors of P450-dependent steroid biosynthesis: from research to medical treatment J Steroid Biochem Mol Biol 8 1003 1021 10.1016/0960-0760(92)90328-G (Pubitemid 23044716)
25. JA Zarn BJ Bruschweiler JR Schlatter 2003 Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14 alpha-demethylase and aromatase Environ Health Perspect 111 255 261