Escitalopram in the treatment of adolescent depression: A randomized placebo-controlled multisite trial

Journal of the American Academy of Child and Adolescent Psychiatry

Volumn 48, Issue 7, 2009, Pages 721-729

  Emslie, Graham J ^a   Ventura, Daniel ^b   Korotzer, Andrew ^b   Tourkodimitris, Stavros ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b Forest Research Institute

Author keywords

Depression; SSRI; Treatment

Indexed keywords

ESCITALOPRAM; PLACEBO;

ABDOMINAL PAIN; ADOLESCENT; ARTICLE; AUTOMUTILATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIARRHEA; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG WITHDRAWAL; FATIGUE; FEMALE; FLU LIKE SYNDROME; GROUPS BY AGE; HUMAN; INCIDENCE; INSOMNIA; IRRITABILITY; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MENSTRUATION DISORDER; MULTICENTER STUDY; NAUSEA; OUTCOME ASSESSMENT; PHARYNGITIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RHINITIS; SIDE EFFECT; SUICIDAL BEHAVIOR; SUICIDAL IDEATION; TREATMENT WITHDRAWAL; UPPER RESPIRATORY TRACT INFECTION; VOMITING;

EID: 68749084664     PISSN: 08908567     EISSN: 15275418     Source Type: Journal    
DOI: 10.1097/CHI.0b013e3181a2b304     Document Type: Article

References (24)

1. Kessler RC, Avenevoli S, Ries Merikangas K. Mood disorders in children and adolescents: an epidemiologic perspective. Biol Psychiatry. 2001;49:1002-1014.
2. Birmaher B, Brent D, Bernet W et al; and AACAP Work Group on Quality Issues. Practice parameter for the assessment and treatment of children and adolescents with depressive disorders. J Am Acad Child Adolesc Psychiatry. 2007;46:1503-1526.
3. Zuckerbrot RA, Cheung AH, Jensen PS, Stein RE, Laraque D; GLAD-PC Steering Group. Guidelines for adolescent depression in primary care (GLAD-PC): I. Identification, assessment, and initial management. Pediatrics. 2007;120:e1299-e1312.
4. Cheung AH, Zuckerbrot RA, Jensen PS, Ghalib K, Laraque D, Stein RE; GLAD-PC Steering Group. Guidelines for adolescent depression in primary care (GLAD-PC): II. Treatment and ongoing management. Pediatrics. 2007;120:e1313-e1326.
5. Middleton H, Shaw I, Hull S, Feder G. NICE guidelines for the management of depression. BMJ. 2005;330:267-268.
6. Bridge JA, Iyengar S, Salary CB et al. Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: a meta-analysis of randomized controlled trials. JAMA. 2007;297:1683-1696.
7. Emslie GJ, Rush AJ, Weinberg WA et al. A double-blind, randomized, placebo-controlled trial of fluoxetine in children and adolescents with depression. Arch Gen Psychiatry. 1997;54:1031-1037.
8. Emslie GJ, Heiligenstein JH, Wagner KD et al. Fluoxetine for acute treatment of depression in children and adolescents: a placebo-controlled, randomized clinical trial. J Am Acad Child Adolesc Psychiatry. 2002;41: 1205-1215.
9. March J, Silva S, Petrycki S et al; Treatment for Adolescents With Depression Study (TADS) Team. Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents with Depression Study (TADS) randomized controlled trial. JAMA. 2004;292:807-820.
10. Wagner KD, Robb AS, Findling RL, Jin J, Gutierrez MM, Heydorn WE. A randomized, placebo-controlled trial of citalopram for the treatment of major depression in children and adolescents. Am J Psychiatry. 2004;161: 1079-1083.
11. Wagner KD, Ambrosini P, Rynn M et al. Sertraline Pediatric Depression Study Group. Efficacy of sertraline in the treatment of children and adolescents with major depressive disorder: two randomized controlled trials. JAMA. 2003;290:1033-1041.
12. Posner K, Oquendo MA, Gould M, Stanley B, Davies M. Columbia Classification Algorithm of Suicide Assessment (C-CASA): classification of suicidal events in the FDA's pediatric suicidal risk analysis of antidepressants. Am J Psychiatry. 2007;164:1035-1043.
13. Hammad TA, Laughren T, Racoosin J. Suicidality in pediatric patients treated with antidepressant drugs. Arch Gen Psychiatry. 2006;63:332-339.
14. Wagner KD, Jonas J, Findling RL, Ventura D, Saikali K. A double-blind, randomized, placebo-controlled trial of escitalopram in the treatment of pediatric depression. J Am Acad Child Adolesc Psychiatry. 2006;45: 280-288.
15. Kaufman J, Birmaher B, Brent D et al. Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry. 1997;36:980-988.
16. Poznanski EO, Cook SC, Carroll BJ. A depression rating scale for children. Pediatrics. 1979;64:442-450.
17. Poznanski EO, Mokros HB. Manual: Children's Depression Rating Scale-Revised. Los Angeles: Western Psychological Services; 1996.
18. Guy W. The clinician global severity and impression scales. In: ECDEU Assessment Manual for Psychopharmacology. Rockville: National Institute of Mental Health; 1976:218-222. DHEW Publication No. 76-338.
19. Shaffer D, Gould MS, Brasic J et al. A children's global assessment scale (CGAS). Arch Gen Psychiatry. 1983;40:1228-1231.
20. Reynolds WM. Professional Manual for the Suicidal Ideation Questionnaire. Odessa: Psychological Assessment Resources; 1987.
21. Mayes TL, Tao R, Rintelmann JW et al. Do children and adolescents have differential response rates in placebo-controlled trials of fluoxetine? CNS Spectr.. 2007;12:147-154.
22. Turner EH, Matthews AM, Linardatos E et al. Selective publication of antidepressant trials and its influence on apparent efficacy. N Engl J Med. 2008;358:252-260.
23. Bridge J, Birmaher B, Iyengar S et al. Placebo response in randomized, controlled trials of antidepressants for pediatric major depressive disorder. Am J Psychiatry. 2009;166:42-49.
24. Emslie GJ. Understanding placebo response in pediatric depression trials. Am J Psychiatry. 2009;166:1-3.