FYX-051, a xanthine oxidoreductase inhibitor, induces nephropathy in rats, but not in monkeys

Toxicologic Pathology

Volumn 37, Issue 4, 2009, Pages 438-445

  Shimo, Takeo ^a   Ashizawa, Naoki ^a   Moto, Mitsuyoshi ^a   Matsumoto, Koji ^a   Iwanaga, Takashi ^a   Nagata, Osamu ^a  

^a Fuji Yakuhin Co Ltd   (Japan)

Author keywords

FYX 051; Monkeys; Nephropathy; Rats; Species differences; Xanthine oxidoreductase inhibitor

Indexed keywords

FYX 051; PURINE; UNCLASSIFIED DRUG; XANTHINE; XANTHINE OXIDASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DISPOSITION; DRUG EXCRETION; DRUG SOLUBILITY; FEMALE; HUMAN; KIDNEY DISEASE; MALE; MONKEY; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PURINE METABOLISM; RAT; SINGLE DRUG DOSE; SPECIES DIFFERENCE; TOXICITY TESTING; TOXICOKINETICS; TREATMENT DURATION; TREATMENT OUTCOME; URINARY EXCRETION; XANTHINE MEDIATED NEPHROPATHY;

ADMINISTRATION, ORAL; ANIMALS; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; KIDNEY; KIDNEY DISEASES; MACACA FASCICULARIS; MALE; NITRILES; PURINES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SPECIES SPECIFICITY; TOXICITY TESTS, CHRONIC; XANTHINE DEHYDROGENASE;

RATTUS;

EID: 68649127873     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623309332995     Document Type: Article

References (6)

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6. Shimo, T, N Ashizawa, K Matsumoto, T Nakazawa, and O Nagata (2005). Simultaneous treatment with citrate prevents nephropathy induced by FYX-051, a xanthine oxidoreductase inhibitor, in rats. Toxicol Sci, 87, 267-76.