Heterologous expression of olfactory receptors for targeted chemosensing

Annals of the New York Academy of Sciences

Volumn 1170, Issue , 2009, Pages 157-160

  Dhanasekaran, Danny N ^a   Radhika, Venkat ^a   Proikas Cezanne, Tassula ^b   Jayaraman, Muralidharan ^a   Ha, Jihee ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Biosensor; Chemosensing; DNT; Olfactory receptor; Olfr226; Yeast

Indexed keywords

2,4 DINITROTOLUENE; GREEN FLUORESCENT PROTEIN;

BIOCHIP; CHEMOSENSITIVITY; CONFERENCE PAPER; FUNGAL STRAIN; GENE EXPRESSION SYSTEM; GENE LIBRARY; GENETIC ENGINEERING; HETEROLOGOUS EXPRESSION; HIGH THROUGHPUT SCREENING; LIGAND BINDING; MOLECULE; NONHUMAN; OLFACTORY RECEPTOR; OLFACTORY SYSTEM; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; YEAST CELL;

MAMMALIA; RATTUS; SACCHAROMYCES CEREVISIAE;

EID: 68649111197     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.04374.x     Document Type: Conference Paper

References (15)

1. Buck, L. & R. Axel. 1991. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65: 175-187.
2. Mombaerts, P. 1999. Seven-transmembrane proteins as odorant and chemosensory receptors. Science 286: 707-711.
3. Malnic, B. et al. 1999. Combinatorial receptor codes for odors. Cell 96: 713-723.
4. Jones, D.T. & R.R. Reed. 1989. Golf: an olfactory neuron specific G protein involved in odorant signal transduction. Science 244: 790-795.
5. Bakalyar, H.A. & R.R. Reed. 1990. Identification of a specialized adenylyl cyclase that may mediate odorant detection. Science 250: 1403-1406.
6. Pace, U. et al. 1985. Odorant-sensitive adenylate cyclase may mediate olfactory reception. Nature 316: 255-258.
7. Russell, M. et al. 1993. Changes in gene expression in the Ras/adenylate cyclase system of Saccharomyces cerevisiae: correlation with cAMP levels and growth arrest. Mol. Biol. Cell 4: 757-765.
8. Lalli, E. & P. Sassone-Corsi. 1994. Signal transduction and gene regulation: the nuclear response to cAMP. J. Biol. Chem. 269: 17359-17362.
9. Krautwurst,D., K.W. Yau & R.R. Reed. 1998. Identification of ligands for olfactory receptors by functional expression of a receptor library. Cell 95: 917- 926.
10. Zhao, H. et al. 1998. Functional expression of a mammalian odorant receptor. Science 279: 237- 242.
11. Radhika, V. et al. 2007. Chemical sensing of DNT by engineered olfactory yeast strain. Nat. Chem. Biol. 3: 325-330.
12. Firestein, S. 2001. How the olfactory system makes sense of scents. Nature 413: 211-218.
13. Araneda, R.C. et al. 2004. A pharmacological profile of the aldehyde receptor repertoire in rat olfactory epithelium. J. Physiol. 555: 743-756.
14. Johnson, G.L. & N. Dhanasekaran. 1989. The G-protein family and their interaction with receptors. Endocr. Rev. 10: 317-331.
15. Kobilka, B.K. et al. 1988. Chimeric α2-, β2- adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. Science 240: 1310-1316.