Effects of increasing doses of vigabatrin on platelet γ-aminobutyric acid-transaminase and brain γ-aminobutyric acid in rats

European Journal of Pharmacology

Volumn 369, Issue 2, 1999, Pages 169-173

  Valdizán, Elsa M ^a   García, Agueda P ^a   Armijo, Juan A ^a  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

Author keywords

Blood platelet; Epilepsy; GABA ( aminobutyric acid); GABA ( aminobutyric acid ) transaminase; Vigabatrin

Indexed keywords

4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRIC ACID; BIOCHEMICAL MARKER; VIGABATRIN;

4 AMINOBUTYRIC ACID BRAIN LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOCYTE;

4-AMINOBUTYRATE TRANSAMINASE; ANIMALS; BIOLOGICAL MARKERS; BLOOD PLATELETS; BRAIN; DRUG ADMINISTRATION SCHEDULE; ENZYME INHIBITORS; GAMMA-AMINOBUTYRIC ACID; MALE; RATS; RATS, WISTAR; TIME FACTORS; VIGABATRIN;

EID: 0033057128     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00061-8     Document Type: Article

References (26)

1. Arteaga R., Herranz J.L., Valdizán E.M., Armijo J.A. Gamma-vinyl GABA (vigabatrin): relationship between doses, plasma concentrations, platelet GABA-transaminase inhibition and seizure reduction in epileptic children. Epilepsia. 33:1992;923-931.
2. Ben-Menachem E., Persson L.I., Schechter P.J., Haegele K.D., Huebert N., Hardenberg J., Dahlgren L., Mumford J.P. The effect of different vigabatrin treatment regimens on CSF biochemistry and seizure control in epileptic patients. Br. J. Clin. Pharmacol. 27(1):1989;79-85. Suppl.
3. Bernasconi R., Klein M., Martin P., Christen P., Hafner T., Portet C., Schmutz M. γ-Vinyl GABA: comparison of neurochemical and anticonvulsant effects in mice. J. Neural Transm. 72:1988;213-233.
4. Bolton J.B., Rimmer E., Williams J., Richens A. The effect of vigabatrin on brain and platelet GABA-transaminase activities. Br. J. Clin. Pharmacol. 27(1):1989;35-42. Suppl.
5. Browne T.R., Mattson R.H., Penry J.K., Smith D.B., Treiman D.M., Wilder B.J., Ben-Menachem E., Napoliello M.J., Sherry K.M., Szabo M.T. Vigabatrin for refractory complex partial seizures: multicenter simple-blind study with long-term follow-up. Neurology. 37:1987;184-189.
6. Gale K. GABA in epilepsy: the pharmacological basis. Epilepsia. 30(3):1989;1-11. Suppl.
7. Gram L., Lyon B.B., Dam M. Gamma-vinyl-GABA: a single-blind trial in patients with epilepsy. Acta Neurol. Scand. 68:1983;34-39.
8. Gram L., Klosterskov P., Dam M. Gamma-vinyl GABA: a double-blind placebo-controlled trial in partial epilepsy. Ann. Neurol. 17:1985;262-266.
9. Grove J., Schechter P.J., Tell G., Koch-Weser J., Sjöerdsma A., Warter C., Marescaux J.M., Rumbach L. Increased γ-aminobutyric acid (GABA), homocarnosine and β-alanine in cerebrospinal fluid of patients treated with γ-vinyl GABA (4-amino-hex-5-enoic acid). Life Sci. 28:1981;2431-2439.
10. Jung M.J., Lappet B., Metcalf B.W., Böhlen P., Schechter P.J. Gamma-vinyl GABA (4 amino-hex-5-enoic acid): a new selective irreversible inhibitor of GABA-T effects on brain GABA metabolism in mice. J. Neurochem. 29:1977;787-812.
11. Kälviäinen R., Halonen T., Pitkänen A., Riekkinen P.J. Amino acid levels in the cerebrospinal fluid of newly diagnosed epileptic patients: effect of vigabatrin and carbamazepine monotherapies. J. Neurochem. 60:1993;1244-1250.
12. Löscher W.W. Effect of inhibitors of GABA aminotransferase on the metabolism of GABA in brain tissue and synaptosomal fraction. J. Neurochem. 364:1981;1521-1527.
13. Löscher W.W., Fassbender C.P., Gram L., Gramer M., Horstermann D., Zahner B., Stefan H. Determination of GABA and vigabatrin in human plasma by a rapid and simple HPLC method: correlation between clinical response to vigabatrin and increase in plasma GABA. Epilepsy Res. 14:1993;245-255.
14. Lowry O.H., Rosenbrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
15. Metcalf B.W. Inhibitors of GABA metabolism. Biochem. Pharmacol. 28:1979;1705-1712.
16. Mumford J.P., Dam M. Meat-analysis of European placebo-controlled studies of vigabatrin in drug-resistant epilepsy. Br. J. Clin. Pharmacol. 27(1):1989;101-107. Suppl.
17. Pitkänen A., Matilainen R., Ruutiainen T., Lehtinen M., Riekkinen P.J. Effect of vigabatrin (γ-vinyl GABA) on amino acid levels in CSF of epileptic patients. J. Neurol. Neurosurg. Psychiatry. 51:1988;1395-1400.
18. Riekkinen P.J., Ylinen A., Halonen T., Sivenius J., Pitkänen A. Cerebrospinal fluid GABA and seizure control with vigabatrin. Br. J. Clin. Pharmacol. 27:1989;87-94.
19. Rimmer E., Kongola G., Richens A. Inhibition of the enzyme, GABA-aminotransferase in human platelet by vigabatrin, a potential antiepileptic drug. Br. J. Clin. Pharmacol. 25:1988;251-259.
20. Schechter P.J., Trainer Y., Jung M.J., Böhlen P. Audiogenic seizure protection by elevated brain GABA concentrations in mice: effects of γ-acetilenic GABA and γ-vinyl GABA two irreversible GABA-T inhibitors. Eur. J. Pharmacol. 45:1977;319-328.
21. Sivenius M.R.J., Ylinen A., Murros K., Matilainen R., Riekkinen P. Double-blind dose reduction study of vigabatrin in complex partial epilepsy. Epilepsia. 28:1987;688-692.
22. Turnell D.C., Cooper J.D.H. Rapid assay for amino acids in serum or urine by pre-column derivatization and reversed-phase liquid chromatography. Clin. Chem. 28:1982;527-531.
23. Valdizán E.M., Armijo J.A. Relationship between platelet and brain GABA-transaminase inhibition by single and multiple doses of vigabatrin in rats. Epilepsia. 32:1991;735-742.
24. Valdizán E.M., Armijo J.A. Effects of single and multiple increasing doses of vigabatrin on brain GABA metabolism and correlation with vigabatrin plasma concentration. Biochem. Pharmacol. 43:1992;2143-2150.
25. White H.L. 4-Aminobutyrate-2-oxoglutarate aminotransferase in blood platelet. Science. 205:1979;696-698.
26. White H.L., Faison L.D. GABA-T in blood platelets: comparison with GABA-T of other tissues. Brain. Res. Bull. 5(2):1980;115-119. Suppl.