Chemo-enzymatic synthesis of degradable PTMC-b-PECA-b-PTMC triblock copolymers and their micelle formation for pH-dependent controlled release

Macromolecular Bioscience

Volumn 9, Issue 6, 2009, Pages 613-621

  Kaihara, Sachiko ^a   Fisher, John P ^b   Matsumura, Shuichi ^a  

^a KEIO UNIVERSITY   (Japan)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

Cyclic acetal; Drug delivery system; Enzymes; Micelles; Poly (trimethylene carbonate)

Indexed keywords

ACIDIC DEGRADATION; AMPHIPHILICS; CHEMICAL COMPOSITIONS; CHEMO-ENZYMATIC SYNTHESIS; CONTROLLED RELEASE; CYCLIC ACETAL; CYCLIC ACETALS; DRUG DELIVERY SYSTEM; DRUG RELEASE STUDY; MICELLE FORMATION; PH SENSITIVE; PH-DEPENDENT; POLY (TRIMETHYLENE CARBONATE); POLY(ETHYLENE GLYCOL); POLYMERIC MICELLE; RELEASE RATE; TRIBLOCK COPOLYMERS;

CARBONATION; CATALYSTS; COPOLYMERIZATION; COPOLYMERS; DEGRADATION; DRUG DELIVERY; ENZYMES; ETHYLENE; ETHYLENE GLYCOL; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; SYNTHESIS (CHEMICAL);

MICELLES;

BUFFER; COPOLYMER; MACROGOL; METHOTREXATE; POLY(TRIMETHYLENE CARBONATE) BLOCK POLY[POLY(ETHYLENE GLYCOL) CO CYCLIC ACETAL] BLOCK POLY(TRIMETHYLENE CARBONATE); UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL COMPOSITION; CHEMICAL MODIFICATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; DEGRADATION; ENZYME MECHANISM; MICELLIZATION; MOLECULAR WEIGHT; PH; SYNTHESIS;

ACETALS; BUFFERS; CALORIMETRY, DIFFERENTIAL SCANNING; DELAYED-ACTION PREPARATIONS; DIOXANES; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; LIPASE; MAGNETIC RESONANCE SPECTROSCOPY; METHOTREXATE; MICELLES; MOLECULAR WEIGHT; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYMERS; TEMPERATURE; TIME FACTORS;

EID: 68649108661     PISSN: 16165187     EISSN: 16165195     Source Type: Journal    
DOI: 10.1002/mabi.200800308     Document Type: Article

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