Long-term effect of losartan administration on blood pressure, heart and structure of coronary artery of young spontaneously hypertensive rats

Physiological Research

Volumn 58, Issue 3, 2009, Pages 327-335

  Koprdova R ^a   Cebova M ^a   Kristek, F ^a  

^a INSTITUTE OF CHEMISTRY   (Slovakia)

Author keywords

Coronary artery; Losartan; SHR; Ultrastructure

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; LOSARTAN;

ANIMAL; ARTICLE; BLOOD PRESSURE; CARDIOMEGALY; CORONARY BLOOD VESSEL; DISEASE MODEL; DRUG ADMINISTRATION; DRUG EFFECT; HEART; HEART MUSCLE; HYPERTENSION; INTIMA; PATHOLOGY; PATHOPHYSIOLOGY; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; TUNICA MEDIA; ULTRASTRUCTURE; WISTAR RAT;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CARDIOMEGALY; CORONARY VESSELS; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; HEART; HYPERTENSION; LOSARTAN; MYOCARDIUM; RATS; RATS, INBRED SHR; RATS, WISTAR; TUNICA INTIMA; TUNICA MEDIA;

EID: 68649090964     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. An SJ, Boyd R, Wang Y, Qiu X, Wang HD: Endothelin-1 expression in vascular adventitial fibroblasts. Am J Physiol 290: H700-H708, 2006.
2. Cebová M, Kristek F, Kuneš J: Differential remodeling of carotid artery in spontaneously hypertensive rats and hereditary hypertriglyceridemic rats. Physiol Res 55 (Suppl 1): S81-S87, 2006.
3. Cunha RS, Dabiré H, Bezie I, Weiss AM, Chanouche-Terzara K, Laurent S, Safar ME, Lacolley P: Mechanical stress of the carotid artery at the early phase of spontaneous hypertension in rats. Hypertension 29: 992-998, 1997.
4. Dantas AP, Franco MC, Silva-Antonialli MM, Tostes RC, Fortes ZB, Nigro D, Carvalho MH: Gender differences in superoxide generation in microvessels of hypertensive rats: role of NAD(P)H-oxidase. Cardiovasc Res 61: 22-29, 2004.
5. Freeman EJ, Ferrario CM, Talllant EA: Angiotensin differentially activate phospholipase D in vascular smooth muscle cells from spontaneously hypertensive and Wistar-Kyoto rats. Am J Hypertension 8: 1105-1111, 1995.
6. Garg UC, Hassid A: Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 83: 1774-1777, 1989.
7. Gerová M, Kristek F, Čačányiová S, Cebová M: Controversial response to acetylcholine and bradykinine in consecutive portions of arterial tree in SHR and SHR treated with NO donors. Braz J Biol Res 38: 959-966, 2005.
8. 2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinindependent mechanism. Hypertension 31: 349-355, 1998.
9. Kaneko K, Susic D, Nunez E, Frohlich ED: Losartan reduces cardiac mass and improves coronary flow reserve in the spontaneously hypertensive rat. J Hypertens 14: 645-653, 1996.
10. Kristek F: Long-term administration of L-arginine did not influence blood pressure, heart rate, cardiac hypertrophy or arterial wall thickness of spontaneously hypertensive rats. Exp Physiol 83: 595-603, 1998.
11. Kristek F, Fáberová V, Varga I: Long-term effect of molsidomine and pentaerythrityl tetranitrate on cardiovascular system of spontaneously hypertensive rats. Physiol Res 52: 709-717, 2003.
12. Kristek F, Koprdová R, Cebová M: Long-term effects of early administered sildenafil and NO donor on the cardiovascular system of SHR. J Physiol Pharmacol 58: 33-43, 2007.
13. Lee RMKW, Forrest JB, Garfield RE, Daniel EE: Ultrastructural changes in mesenteric arteries from spontaneously hypertensive rats. A morphometric study. Blood Vessels 20: 72-91, 1983.
14. 2 induced contractions in canine coronary arteries. J Pharmacol Exp Ther 281: 1065-1070, 1997.
15. Liu H, Ledingham JM, Mullaney I, Laserty R: Endothelial function in mesenteric resistance arteries from genetically hypertensive rat. Clin Exp Pharmacol Physiol 29: 405-411, 2002.
16. Lopez B, Gonzales A, Varo N, Laviades C, Querejeta R, Diez J: Biochemical assessment of myocardial fibrosis in hypertensive heart disease. Hypertension 38: 1222-1226, 2001.
17. Morton JJ, Beattie EC, MacPherson F: Angiotensin II receptor antagonist losartan has persistent effects on blood pressure in the young spontaneously hypertensive rat: lack of relation to vascular structure. J Vasc Res 29: 264-269, 1992.
18. Mulvany MJ, Aalkajaer C, Christensen J: Changes in noradrenaline sensitivity and morphology of arterial resistance vessels during development of high blood pressure in spontaneously hypertensive rats. Hypertension 2: 664-671, 1980.
19. Okamoto K, Aoki K: Development of a strain of spontaneously hypertensive rats. Jpn Circ J 27: 282-293, 1963.
20. Olivetti G, Anversa P, Melissari M, Loud AV: Morphometric study of early postnatal development of the thoracic aorta in the rat. Circ Res 47: 417-424, 1980.
21. Olivetti G, Melissari M, Marchetti G, Anversa P: Quantitative structural changes of the rat thoracic aorta in early spontaneous hypertension. Tissue composition, and hypertrophy and hyperplasia of smooth muscle cells. Circ Res 51: 19-26, 1982.
22. Olson S, Oeckler R, Li XM, Du LT, Traganos F, Zhao XM, Burke-Wolin T: Angiotensin II stimulates nitric oxide production in pulmonary artery endothelium via the type 2 receptor. Am J Physiol 287: L559-L568, 2004.
23. Owens GK, Schwartz SM: Alterations in vascular smooth muscle mass in the spontaneously hypertensive rat: role of cellular hypertrophy, hyperploidy and hyperplasia. Circ Res 51: 280-289, 1982.
24. Paulis L, Líšková S, Pintérová M, Dobešová Z, Kuneš J, Zicha J: Nifedipine-sensitive noradrenergic vasoconstriction is enhanced in spontaneously hypertensive rats: the influence of chronic captopril treatment. Acta Physiol 191: 255-266, 2007.
25. Pourageaud F, Freslon JL: Impaired endothelial relaxations induced by agonists and flow in spontaneously hypertensive rat compared to Wistar-Kyoto rat perfused coronary arteries. J Vasc Res 32: 190-199, 1995.
26. Rizzoni D, Porteri E, Piccoli A, Castellano M, Bettoni G, Muiesan ML, Pasini G, Guelfi D, Mulvany MJ, Agabiti-Rosei E: Effects of losartan and enalapril on small artery structure in hypertensive rats. Hypertension 32: 305-310, 1998.
27. Rosendorf C: The renin-angiotensin system and vascular hypertrophy. J Am Coll Cardiol 28: 803-812. 1996.
28. Ruiz-Gayo M, Somoza B, Bravo R, Fernandez-Alonso MS, Gonzales C: Chronic losartan treatment decreases angiotensin II-mediated facilitation of noradrenaline release in caudal artery of spontaneously hypertensive rats. Life Sci 67: 3153-3162, 2000.
29. Silva-Antonialli MM, Fortes ZB, Carvalho MHC, Scivoletto R, Nigro D: Sexual dimorphism in the response of thoracic aorta from SHRs to losartan. Gen Pharmacol 34: 329-335, 2000.
30. Soltis EE: Alterations in vascular structure and function after short-term losartan treatment in spontaneously hypertensive rats. J Pharmacol Exp Ther 266: 642-646, 1993.
31. Soltis EE, Jewell AL, Dwoskin LP, Cassis LA: Acute and chronic effects of losartan (DUP-753) on blood-pressure and vascular reactivity in normotensive rats. Clin Exp Hypertens 15: 171-184, 1993.
32. G-nitro-L-arginine methyl ester-induced hypertension and natriuretic peptide gene expression: Inhibition by angiotensin II type 1 receptor antagonist. J Cardiovasc Pharmacol 40: 478-486, 2002.
33. Tea BS, der Sarkisian S, Touyz RH, Hamet P, de Blois D: Proapoptotic and growth-inhibitory role of angiotensin II type 2 receptor in vascular smooth muscle cells of spontaneously hypertensive rats in vivo. Hypertension 35: 1069-1073, 2000.
34. Torok J, Koprdová R, Cebová M, Kristek F: Functional and structural pattern of arterial responses in hereditary hypertriglyceridemic and spontaneously hypertensive rats in early stage of experimental hypertension. Physiol Res 55 (Suppl 1): S65-S71, 2006.
35. Thubrikar MJ, Robiscek F: Pressure-induced arterial-wall stress and atherosclerosis. Ann. Thorac Surg 59: 1594-1603, 1995.
36. Varo N, Iraburu MJ, Varela M, Lopez B, Etayo JC, Díez J: Chronic AT1 blockade stimulates extracellular collagen type I degradation and reverses myocardial fibrosis in spontaneously hypertensive rats. Hypertension 35: 1197-1202, 2000.
37. Weibel ER, Kisteler GS, Scherle WF: Practical stereological methods for morpfometric cytology. J Cell Biol 30: 23-38, 1966.
38. Yokoyama H, Averill DB, Brosnihan KB, Smith RD, Schiffrin EL, Ferrario CM: Role of blood pressure reduction in prevention of cardiac and vascular hypertrophy. Am J Hypertens 18: 922-929, 2005.