Effect of melatonin and time of administration on irradiation-induced damage to rat testes

Brazilian Journal of Medical and Biological Research

Volumn 42, Issue 7, 2009, Pages 621-628

  Take, G ^a   Erdogan, D ^a   Helvacioglu, F ^a   Goktas G ^a   Ozbey, G ^a   Uluoglu, C ^a   Yucel B ^a   Guney, Y ^b   Hicsonmez, A ^b   Ozkan, S ^a  

^a GAZI UNIVERSITY   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

Author keywords

Electron microscopy; Gamma irradiation; Immunohistochemistry; Melatonin; Testes

Indexed keywords

CASPASE 3; MELATONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CHRONOBIOLOGY; CONTROLLED STUDY; DRUG DOSE REGIMEN; ELECTRON MICROSCOPY; HORMONE ACTION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IONIZING RADIATION; MALE; NONHUMAN; RADIATION DOSE; RADIATION RESPONSE; RAT; SPERMATOCYTE; TESTIS INJURY; TIME; WHOLE BODY RADIATION;

RATTUS; RATTUS NORVEGICUS;

EID: 68649086691     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2009000700006     Document Type: Article

References (22)

1. Cordelli E, Fresegna AM, Leter G, Eleuteri P, Spano M, Villani P. Evaluation of DNA damage in different stages of mouse spermatogenesis after testicular X irradiation. Radiat Res 2003; 160: 443-451.
2. Sapp WJ, Philpott DE, Williams CS, Williams JW, Kato K, Miquel JM, et al. Comparative study of spermatogonial survival after X-ray exposure, high LET (HZE) irradiation or spaceflight. Adv Space Res 1992; 12: 179-189.
3. Sapp WJ, Philpott DE, Williams CS, Kato K, Stevenson J, Vasquez M, et al. Effects of spaceflight on the spermatogonial population of rat seminiferous epithelium. FASEB J 1990; 4: 101-104.
4. Badr FM, El Habit OH, Harraz MM. Radioprotective effect of melatonin assessed by measuring chromosomal damage in mitotic and meiotic cells. Mutat Res 1999; 444: 367-372.
5. Kim JK, Lee CJ. Effect of exogenous melatonin on the ovarian follicles in gamma-irradiated mouse. Mutat Res 2000; 449: 33-39.
6. Vera H, Tijmes M, Ronco AM, Valladares LE. Melatonin binding sites in interstitial cells from immature rat testes. Biol Res 1993; 26: 337-340.
7. Vijayaiaxmi, Reiter RJ, Tan DX, Herman TS, Thomas CR Jr. Melatonin as a radioprotective agent: a review. Int J Radiat Oncol Biol Phys 2004; 59: 639-653.
8. Claustrat B, Geoffriau M, Brun J, Chazot G. [Melatonin in humans: a biochemical marker of the circadian clock and an endogenous synchronizer]. Neurophysiol Clin 1995; 25: 351-359.
9. Ianas O, Olinescu R, Badescu I. Melatonin involvement in oxidative processes. Endocrinologie 1991; 29: 147-153.
10. Pieri C, Marra M, Moroni F, Recchioni R, Marcheselli F. Melatonin: a peroxyl radical scavenger more effective than vitamin E. Life Sci 1994; 55: L271-L276.
11. Reiter RJ. Intaractions of the pineal hormone melatonin with oxygen-centered free radicals: a brief review. Braz J Med Biol Res 1993; 26: 1141-1155.
12. Reiter RJ. Functional pleiotropy of the neurohormone melatonin: antioxidant protection and neuroendocrine regulation. Front Neuroendocrinol 1995; 16: 383-415.
13. Reiter R, Tang L, Garcia JJ, Munoz-Hoyos A. Pharmacological actions of melatonin in oxygen radical pathophysiology. Life Sci 1997; 60: 2255-2271.
14. Mornjakovic Z, Scepovic M, Kundurovic Z. [Morphometric aspects of seminiferous tubules in rats treated with melatonin and whole body irradiation (stereologic analysis)]. Med Arh 1991; 45: 9-10.
15. Mornjakovic Z, Alicelebic S, Bilalovic N, Susko I. [Morphometric characteristics of Leydig cells after total irradiation of rats treated with melatonin]. Med Arh 1998; 52: 183-184.
16. Koc M, Buyukokuroglu ME, Taysi S. The effect of melatonin on peripheral blood cells during total body irradiation in rats. Biol Pharm Bull 2002; 25: 656-657.
17. Sener G, Jahovic N, Tosun O, Atasoy BM, Yegen BC. Melatonin ameliorates ionizing radiation-induced oxidative organ damage in rats. Life Sci 2003; 74: 563-572.
18. Taysi S, Koc M, Buyukokuroglu ME, Altinkaynak K, Sahin YN. Melatonin reduces lipid peroxidation and nitric oxide during irradiation-induced oxidative injury in the rat liver. J Pineal Res 2003; 34: 173-177.
19. Pinon-Lataillade G, Velez de la Calle JF, Viguier-Martinez MC, Garnier DH, Folliot R, Maas J, et al. Influence of germ cells upon Sertoli cells during continuous low-dose rate gamma-irradiation of adult rats. Mol Cell Endocrinol 1988; 58: 51-63.
20. Dedov VI. [Ultrastructure of rat Sertoli and Leydig cells normally and under prolonged internal irradiation]. Tsitologiia 1980; 22: 1153-1156.
21. Sawada H, Esaki M. Electron microscopic observation of 137Cs-irradiated rat testis: production of basal laminae for germ cells, despite their absence. J Electron Microsc 2003; 52: 391-397.
22. Hussein MR, Abu-Dief EE, Abou El-Ghait AT, Adly MA, Abdelraheem MH. Morphological evaluation of the radioprotective effects of melatonin against X-ray-induced early and acute testis damage in Albino rats: an animal model. Int J Exp Pathol 2006; 87: 237-250.