Characterization of α-nitromethyl ketone as a new zinc-binding group based on structural analysis of its complex with carboxypeptidase A

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 17, 2009, Pages 5009-5011

  Wang, Shou Feng ^a   Tian, Guan Rong ^a   Zhang, Wen Zheng ^b   Jin, Jing Yi ^a  

^a YANBIAN UNIVERSITY   (China)

^b INSTITUTE OF BIOPHYSICS   (China)

Author keywords

Crystal structure; Transition state analog; Zinc binding group

Indexed keywords

2 BENZYL 5 NITRO 4 OXOPENTANOIC ACID; CARBOXYPEPTIDASE A; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHELATION; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG SYNTHESIS; HYDROGEN BOND; STRUCTURE ANALYSIS; X RAY DIFFRACTION;

BINDING SITES; CARBOXYPEPTIDASES A; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; KETONES; MOLECULAR CONFORMATION; PROTEASE INHIBITORS; PROTEIN BINDING; ZINC;

EID: 68549120890     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.060     Document Type: Article

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