Insulin-stimulated increase in serum leptin levels precedes and correlates with weight gain during insulin therapy in type 2 diabetes

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 8, 2009, Pages 2900-2906

  Aas, Anne Marie ^a,b   Hanssen, Kristian F ^a,b   Berg, Jens Petter ^a,b   Thorsby, Per M ^a,b   Birkeland, Kåre I ^a,b  

^a AKER UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

GLIBENCLAMIDE; GLIMEPIRIDE; GLIPIZIDE; ISOPHANE INSULIN; LEPTIN; METFORMIN; SULFONYLUREA;

ADULT; AGED; ARTICLE; BODY WEIGHT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HORMONE BLOOD LEVEL; HUMAN; HYPERLEPTINEMIA; INSULIN INFUSION; INSULIN TREATMENT; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TREATMENT OUTCOME; WEIGHT GAIN;

EID: 68549110230     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-1005     Document Type: Article

References (23)

1. Aas AM, Bergstad I, Thorsby PM, Johannesen O, Solberg M, Birkeland KI 2005 An intensified lifestyle intervention programme may be superior to insulin treatment in poorly controlled type 2 diabetic patients on oral hypoglycaemic agents: results of a feasibility study. Diabet Med 22:316-322
2. Birkeland KI, Rishaug U, Hanssen KF, Vaaler S 1996 NIDDM: a rapid progressive disease. Results from a long-term, randomised, comparative study of insulin or sulphonylurea treatment. Diabetologia 39:1629-1633
3. Leslie WS, Hankey CR, Lean MEJ 2007 Weight gain as an adverse effect of some commonly prescribed drugs: a systematic review.QJ Med 100:395-404
4. Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S, Lechler RI, DePaoli AM, O'Rahilly S 2002 Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/ metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 110:1093-1103
5. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM 1995 Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546
6. Munzberg H, Myers Jr MG 2005 Molecular and anatomical determinants of central leptin resistance. Nat Neurosci 8:566-570
7. Schwartz MW, Niswender KD 2004 Adiposity signaling and biological defense against weight gain: absence of protection or central hormone resistance? J Clin Endocrinol Metab 89:5889-5897
8. Scarpace PJ, Zhang Y 2007 Elevated leptin: consequence or cause of obesity? Front Biosci 12:3531-3544
9. Malmstrom R, Taskinen MR, Karonen SL, Yki-Jarvinen H 1996 Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM. Diabetologia 39:993-996
10. Utriainen T, Malmstrom R, Makimattila S, Yki-JarvinenH1996 Supraphysiological hyperinsulinemia increases plasma leptin concentrations after 4 h in normal subjects. Diabetes 45:1364-1366
11. Carey PE, Stewart MW, Ashworth L, Taylor R 2003 Effect of Insulin therapy on plasma leptin and body weight in patients with type 2 diabetes. Horm Metab Res 35:372-376
12. Widjaja A, Stratton IM, Horn R, Holman RR, Turner R, Brabant G 1997 UKPDS 20: plasma leptin, obesity, and plasma insulin in type 2 diabetic subjects. J Clin Endocrinol Metab 82:654-657
13. Birkeland KI, Kilhovd B, Thorsby P, Torjesen PA, Ganss R, Vaaler S, Hanssen KF 2003 Heterogeneity of non-insulin-dependent diabetes expressed as variability in insulin sensitivity, beta-cell function and cardiovascular risk profile. Diabet Med 20:37-45
14. Aas AM, Seljeflot I, Torjesen P, Diep L, Thorsby P, Birkeland K 2006 Blood glucose lowering by means of lifestyle intervention has different effects on adipokines as compared with insulin treatment in subjects with type 2 diabetes. Diabetologia 49:872-880
15. Birkeland KI, Chatzipanagiotou F, Hanssen KF, Vaaler S 1992 Relationship between blood pressure and in vivo action of insulin in type II (non-insulindependent) diabetic subjects. Metab Clin Exp 41:301-305
16. Saad MF, Khan A, Sharma A, Michael R, Riad-Gabriel MG, Boyadjian R, Jinagouda SD, Steil GM, Kamdar V 1998 Physiological insulinemia acutely modulates plasma leptin. Diabetes 47:544-549
17. Ahmed ML, Ong KKL, Watts AP, Morrell DJ, Preece MA, Dunger DB 2001 Elevated leptin levels are associated with excess gains in fat mass in girls, but not boys, with type 1 diabetes: longitudinal study during adolescence. J Clin Endocrinol Metab 86:1188-1193
18. Celi F, Bini V, Papi F, Santilli E, Castellani MS, Ferretti A, Mencacci M, Berioli MG, De Giorgi G, Falorni A 2006 Circulating adipocytokines in non-diabetic and type 1 diabetic children: relationship to insulin therapy, glycaemic control and pubertal development. Diabet Med 23:660-665
19. Hanaki K, Becker DJ, Arslanian SA 1999 Leptin before and after insulin therapy in children with new-onset type 1 diabetes. J Clin Endocrinol Metab 84: 1524-1526
20. Sivitz WI, Wayson SM, Bayless ML, Larson LF, Sinkey C, Bar RS, Haynes WG 2003 Leptin and body fat in type 2 diabetes and monodrug therapy. J Clin Endocrinol Metab 88:1543-1553
21. McCowen KC, Ling PR, Friel C, Sternberg J, Forse RA, Burke PA, Bistrian BR 2002 Patterns of plasma leptin and insulin concentrations in hospitalized patients after the initiation of total parenteral nutrition. Am J Clin Nutr 75:931-935
22. Shimizu H, Oh IS, Okada S, Mori M 2007 Leptin resistance and obesity. Endocr J 54:17-26
23. Lofgren P, Andersson I, Adolfsson B, Leijonhufvud BM, Hertel K, Hoffstedt J, Arner P 2005 Long-term prospective and controlled studies demonstrate adipose tissue hypercellularity and relative leptin deficiency in the postobese state. J Clin Endocrinol Metab 90:6207-6213