Difference in disease burden and activity in pediatric patients on brain magnetic resonance imaging at time of multiple sclerosis onset vs adults

Archives of Neurology

Volumn 66, Issue 8, 2009, Pages 967-971

  Waubant, Emmanuelle ^a   Chabas, Dorothee ^a   Okuda, Darin T ^b   Glenn, Orit ^c   Mowry, Ellen ^b   Henry, Roland G ^c   Strober, Jonathan B ^a   Soares, Bruno ^c   Wintermark, Max ^c   Pelletier, Daniel ^b  

^a UCSF Multiple Sclerosis Center   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GADOLINIUM;

ADULT; ARTICLE; BRAIN STEM; CEREBELLUM; CHILD; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CORPUS CALLOSUM; DISEASE ACTIVITY; ETHNIC DIFFERENCE; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; POSTERIOR FOSSA; PRIORITY JOURNAL; RACE DIFFERENCE; SCHOOL CHILD;

AGE OF ONSET; BRAIN; CHILD; COST OF ILLNESS; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; RETROSPECTIVE STUDIES;

EID: 68549092842     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneurol.2009.135     Document Type: Article

References (20)

1. Simone IL, Carrara D, Tortorella C, et al. Course and prognosis in early-onset MS: comparison with adult-onset forms. Neurology. 2002;59(12):1922-1928.
2. Chabas D, Mc Culloch C, Strober J, Ferriero D, Waubant E. Age modifies MS phenotype at onset. Mult Scler. 2008;14(suppl 1):S61.
3. Hahn CD, Shroff M, Blaser S, Banwell BL. MRI criteria for multiple sclerosis: evaluation in a pediatric cohort. Neurology. 2004;62(5):806-808.
4. McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnostic of multiple sclerosis. Ann Neurol. 2001;50(1):121-127.
5. Balássy C, Bernert G, Wöber-Bingöl C, et al. Long-term MRI observations of childhood-onset relapsing-remitting multiple sclerosis. Neuropediatrics. 2001;32 (1):28-37.
6. Mikaeloff Y, Adamsbaum C, Husson B, et al; KIDMUS Study Group on Radiology. MRI prognostic factors for relapse after acute CNS inflammatory demyelination in childhood. Brain. 2004;127(pt 9):1942-1947.
7. Chabas D, Castillo Trivino T, Mowry E, Strober J, Glenn O, Waubant E. Vanishing MS T2-bright lesions before puberty: a distinct MRI phenotype? Neurology. 2008;71(14):1090-1093.
8. Ghassemi R, Antel SB, Narayanan S, et al; Canadian Pediatric Demyelinating Disease Study Group. Lesion distribution in children with clinically isolated syndromes. Ann Neurol. 2008;63(3):401-405.
9. Krupp LB, Banwell B, Tenembaum S; International Pediatric MS Study Group. Consensus definitions proposed for pediatric multiple sclerosis and related disorders. Neurology. 2007;68(16)(suppl 2):S7-S12.
10. Polman CH, Reingold SC, Edan G, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald criteria." Ann Neurol. 2005;58(6):840-846.
11. Henry RG, Shieh M, Okuda DT, Evangelista A, Gorno-Tempini ML, Pelletier D. Regional gray matter atrophy in clinically isolated syndromes at presentation [published online May 9, 2008]. J Neurol Neurosurg Psychiatry. 2008;79(11):1236-1244.
12. Renoux C, Vukusic S, Mikaeloff Y, et al; Adult Neurology Departments KIDMUS Study Group. Natural history of multiple sclerosis with childhood onset. N Engl J Med. 2007;356(25):2603-2613.
13. Engelbrecht V, Rassek M, Preiss S, Wald C, Mödder U. Age-dependent changes in magnetization transfer contrast of white matter in the pediatric brain. AJNR Am J Neuroradiol. 1998;19(10):1923-1929.
14. Neuteboom RF, Boon M, Catsman Berrevoets CE, et al. Prognostic factors after a first attack of inflammatory CNS demyelination in children. Neurology. 2008; 71(13):967-973.
15. Filippi M, Wolinsky JS, Sormani MP, Comi G; European/Canadian Glatiramer Acetate Study Group. Enhancement frequency decreases with increasing age in relapsing-remitting multiple sclerosis. Neurology. 2001;56(3):422-423.
16. Filippi M, Horsfield MA, Morrissey SP, et al. Quantitative brain MRI lesion load predicts the course of clinically isolated syndromes suggestive of multiple sclerosis. Neurology. 1994;44(4):635-641.
17. Brex PA, O'Riordan JI, Miszkiel KA, et al. Multisequence MRI in clinically isolated syndromes and the early development of MS. Neurology. 1999;53(6): 1184-1190.
18. Minneboo A, Barkhof F, Polman CH, Uitdehaag BM, Knol DL, Castelijns JA. Infratentorial lesions predict long-term disability in patients with initial findings suggestive of multiple sclerosis. Arch Neurol. 2004;61(2):217-221.
19. Jacobs LD, Beck R, Simon J, et al; CHAMPS Study Group. Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. N Engl J Med. 2000;343(13):898-904.
20. Kappos L, Freedman MS, Polman CH, et al; BENEFIT Study Group. Effect of early versus delayed interferon beta-1b treatment on disability after a first clinical event suggestive of multiple sclerosis: a 3-year follow-up analysis of the BENEFIT study. Lancet. 2007;370(9585):389-397.