Increased oxygen free radical production from isolated human PMNLs and whole blood by luminol-enhanced chemiluminescence in autistic children

Kuwait Medical Journal

Volumn 41, Issue 1, 2009, Pages 26-30

  Al Ayadhi, Laila Y ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Autism; Chemiluminescence; Neutrophils; Whole blood

Indexed keywords

OXYGEN RADICAL; PHORBOL 13 ACETATE 12 MYRISTATE; REACTIVE OXYGEN METABOLITE;

ANTIOXIDANT ACTIVITY; ARTICLE; AUTISM; BLOOD ANALYSIS; CELL ASSAY; CELL ISOLATION; CELL SEPARATION; CELL VIABILITY; CHEMOLUMINESCENCE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; MALE; MENTAL DEFICIENCY; NEUTROPHIL; POLYMORPHONUCLEAR CELL; SAUDI ARABIA;

EID: 68549083774     PISSN: 00235776     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Freeman WJ. Neurohormonal brain dynamic of social group formation. Implication for autism. Ann NY Acad Sci 1997; 807:501-503.
2. Waterhouse L, Fein D, Modahl C. Neurofunctional mechanisms in autism. Psychol Rev 1996; 103:457-489.
3. Dantzer R, Kelley KW. Autistic children: a neuroimmune perspective. Brain Behav Immun 2008; 22:804-805.
4. Sogut S, Zoroglu SS, Ozyurt H, et al. Changes in nitric oxide levels and antioxidant enzyme activities may have a role in the pathophysiological mechanisms involved in autism, Clin Chim Acta 2003; 331:111-117.
5. Yorbik O, Sayal A, Akay C, Akbiyik DI, Sohmen T. Investigation of antioxidant enzymes in children with autistic disorder. Prostaglandins Leukot Essent Fatty Acids 2002; 67:341-343.
6. Granot E, Kohen R. Oxidative stress in childhood - in health and disease states, Clin Nutr 2004; 23:3-11.
7. Stohs SJ. The role of free radicals in toxicity and disease, J. Basic Clin Physiol Pharmacol 1995; 6:205-228.
8. Ng F, Berk M, Dean O, Bush AI. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol 2008; 11:851-876.
9. James SJ, Cutler P, Melnyk S, et al. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr 2004; 80:1611-1617.
10. Chauhan A, Chauhan V. Oxidative stress in autism. Pathophysiology 2006; 13:171-181.
11. Jadhav S, Bochner BS, Konstantopoulos K. Hydrodynamic shear regulates the kinetics and receptor specificity of polymorphonuclear leukocyte-colon carcinoma cell adhesive interactions. J Immunol 2001; 167: 5986-5993.
12. AL-Ayadhi L. The effect of adrenomedullin on oxygen free radicals production and aggregation of isolated human polymorphoneuclear leukocyte. Saudi Pharmaceutical Journal 2004; 12:80-85.
13. Al-Tuwaijri AS, Mustafa AA. Verapamil enhances the inhibitory effects of diclofenac on the chemiluminescence of human polymorphonuclear leukocytes and carrageenan-induced rat's paw oedema. Int J Immunopharmacol 1992; 14:83-91.
14. Gutterridge JMC, Richmond R, Halliwell B. Oxygen free-radicals and lipid peroxidation. Inhibition by the protein ceruloplasmin, FEBS Lett 1980; 112: 269-272.
15. Vendemiale G., Grattagliano I, Altomare E. An update on the role of free radicals and antioxidant defense in human disease. Int J Clin Lab Res 1999; 29:49-55.
16. Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 1990; 186:1-85.
17. Loeffler DA, Connor JR, Juneau PL, et al. Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions. J Neurochem 1995; 65:710-724.
18. Kannan K, Jain SK. Oxidative stress and apoptosis. Pathophysiology 2000; 7:153-163.
19. Juurlink BH, Paterson PG. Review of oxidative stress in brain and spinal cord injury: suggestions for pharmacological and nutritional management strategies. J Spinal Cord Med 1998; 21:309-334.
20. Shulman RG, Rothman DL, Behar KL, Hyder V. Energetic basis of brain activity: implications for neuroimaging. Trends Neurosci 2004; 27:489-495.
21. Perry SW, Norman JP, Litzburg A, Gelbard HA Antioxidants are required during the early critical period, but not later, for neuronal survival. J Neurosci Res 2004; 78:485-492.
22. Ono H, Sakamoto A, Sakura N. Plasma total glutathione concentrations in healthy pediatric and adult subjects, Clin Chim Acta 2001; 312:227-229.
23. Zoroglu SS, Armutcu F, Ozen S, et al. Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism. Eur Arch Psychiatr Clin Neurosci 2004; 254:143-147.
24. Prado CA, Eberhart CG. The Neurobiology of Autism. Brain Pathol 2007; 17:434-447.
25. Kemper TL, Bauman ML. The contribution of neuropathologic studies to the understanding of autism. Neurol Clin 1993; 11:175-187.
26. Bailey A, Luthert P, Dean A, et al. A clinicopathological study of autism. Brain 1998; 121:889-905.
27. Schmahmann JD. An emerging concept. The cerebellar contribution to higher function. Arch Neurol 1991; 48:1178-1187.
28. Trevarthen C. Autism as neurodevelopmental disorder affecting communication and learning in early childhood: prenatal origins, postnatal course and effective educational support. Prostaglandins Leukot Essent Fatty Acids 2000; 6:41-46.
29. Sajdel-Sulkowska EM, Lipinski B, Windom H, Audhya T, McGinnis W. Oxidative Stress in Autism: Elevated cerebellar 3-nitrotyrosine levels. American Journal of Biochemistry and Biotechnology 2008; 4: 73-84.
30. Kroemer G, Dallaporta B, Resch-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol. 1998; 60: 619-642.
31. Lombard J. Autism: a mitochondrial disorder? Med Hypotheses 1998; 50:497-500.