Homozygosity of MSH2 c.1906G→C germline mutation is associated with childhood colon cancer, astrocytoma and signs of Neurofibromatosis type i

Familial Cancer

Volumn 8, Issue 3, 2009, Pages 187-194

  Toledano, Helen ^a   Goldberg, Yael ^b   Kedar Barnes, Inbal ^c   Baris, Hagit ^c   Porat, Rinnat M ^b   Shochat, Chen ^d   Bercovich, Dani ^d,e   Pikarsky, Eli ^b   Lerer, Israela ^b   Yaniv, Isaac ^a   Abeliovich, Dvorah ^b   Peretz, Tamar ^b  

^a TEL AVIV UNIVERSITY   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c RABIN MEDICAL CENTER   (Israel)

^d MIGAL GALILEE TECHNOLOGY CENTER   (Israel)

^e TEL HAI COLLEGE   (Israel)

Author keywords

Ashkenazi; Bi allelic; HNPCC, NF1; MMR; MSH2; MSI

Indexed keywords

BEVACIZUMAB; FLUOROURACIL; FOLINIC ACID; GENOMIC DNA; IRINOTECAN; OXALIPLATIN; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6;

ADOLESCENT; ADULT; ALLELE; ARTICLE; ASTROCYTOMA; CANCER ADJUVANT THERAPY; CANCER RADIOTHERAPY; CANCER TISSUE; CHILDHOOD CANCER; CLINICAL ARTICLE; COLON CANCER; DENATURING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ENDOMETRIUM CANCER; FAMILY HISTORY; FEMALE; GENE EXPRESSION; GENE MUTATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GERM LINE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; JEW; LEUKOPLAKIA; MALE; MICROSATELLITE INSTABILITY; NEUROFIBROMATOSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCREAS CANCER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROCTOCOLECTOMY; RECTUM CARCINOMA; VOCAL CORD;

ADOLESCENT; ASTROCYTOMA; CHILD; COLONIC NEOPLASMS; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; GERM-LINE MUTATION; HOMOZYGOTE; HUMANS; MALE; MUTS HOMOLOG 2 PROTEIN; NEUROFIBROMATOSIS 1; PEDIGREE;

EID: 68449100729     PISSN: 13899600     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10689-008-9227-3     Document Type: Article

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