Unraveling progesterone-induced molecular mechanisms in physiological and pathological conditions

Current Clinical Pharmacology

Volumn 4, Issue 2, 2009, Pages 148-153

  Rocha, Ana ^a   Soares, Raquel ^a  

^a University of Porto   (Portugal)

Author keywords

Cardiovascular system; Growth factors; PDGF; Progesterone; Progesterone receptors; Reproductive system; Signaling pathways

Indexed keywords

CONTRACEPTIVE AGENT; GESTAGEN; PROGESTERONE; PROGESTERONE RECEPTOR;

ANGIOGENESIS; BIOLOGICAL ACTIVITY; BREAST CANCER; BREAST DEVELOPMENT; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; DRUG MECHANISM; ENDOMETRIUM CANCER; FEMALE GENITAL SYSTEM; GENE TARGETING; GENETIC TRANSCRIPTION; HORMONAL THERAPY; HORMONE ACTION; HORMONE DEFICIENCY; HORMONE RECEPTOR INTERACTION; HORMONE SUBSTITUTION; HUMAN; MALE GENITAL SYSTEM; MOLECULAR DYNAMICS; NEUROPROTECTION; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; VASCULARIZATION;

ANIMALS; CELL NUCLEUS; CYTOPLASM; FEMALE; HUMANS; MALE; PHOSPHORYLATION; PROGESTERONE; PROGESTINS; PROTEIN ISOFORMS; RECEPTORS, PROGESTERONE; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 68449083187     PISSN: 15748847     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488409788184963     Document Type: Review

References (44)

1. Brosens JJ, Tullet J, Varshochi R, Lam E. Steroid receptor action. Best Pract Res Clin Obstet Gynaecol 2004; 18: 265-83.
2. Drummond AE. The role of steroids in follicular growth. Reprod Biol Endocrinol 2006; 4: 16.
3. Fernandez-Valdivia R, Mukherjee A, Amato P, et al. Progesterone action in the murine uterus and mammary gland requires steroid receptor coactivator 2: relevance to the human. Front Biosci 2007; 12: 3640-7.
4. Teilmann SC, Clement CA, Thorup J, Byskov AG, Christensen ST. Expression and localization of the progesterone receptor in mouse and human reproductive organs. J Endocrinol 2006; 191: 525-35.
5. Peluso JJ. Multiplicity of progesterone's actions and receptors in the mammalian ovary. Biol Reprod 2006; 75: 2-8.
6. Zakar T, Hertelendy F. Progesterone withdrawal: key to parturition. Am J Obstet Gynecol 2007; 196: 289-96.
7. Henderson LP. Steroid modulation of GABAA receptor-mediated transmission in the hypothalamus: effects on reproductive function. Neuropharmacology 2007; 52: 1439-53.
8. Mellon SH. Neurosteroid regulation of central nervous system development. Pharmacol Ther 2007; 116: 107-24.
9. Ronnekleiv OK, Kelly MJ. Diversity of ovarian steroid signaling in the hypothalamus. Front Neuroendocrinol 2005; 26: 65-84.
10. Poole AJ, Li Y, Kim Y, Lin SCJ, Lee WH, Lee EP. Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist. Science 2006; 314: 1467-70.
11. Pasqualini JR. Progestins and breast cancer. Gynecol Endocrinol 2007; 23: 32-41.
12. Oettel M, Mukhopadhyay AK. Progesterone: the forgotten hormone in men. The Aging Male 2004; 7: 236-57.
13. Edwards DP. Regulation of signal transduction pathways by estrogen and progesterone. Annu Rev Physiol 2005; 67: 335-76.
14. Rocha A, Azevedo I, Soares R. Progesterone sensitizes breast cancer MCF7 cells to imatinib inhibitory effects. J Cell Biochem 2008; 103: 607-14.
15. Scharfman HE, MacLusky NJ. The influence of gonadal hormones on neuronal excitability, seizures and epilepsy in female. Epilepsia 2007; 48: 1030-1.
16. Schumacher M, Guennoun R, Stein DG, Nicola AF. Progesterone: Therapeutic opportunities for neuroprotection and myelin repair. Pharmacol Ther 2007; 116: 77-106.
17. Mani SK. Signaling mechanisms in progesterone-neurotransmitter interactions. Neuroscience 2006; 138: 773-81.
18. Qiao X, McConnell KR, Khalil RA. Sex steroids and vascular responses in hypertension and aging. Gend Med 2008; 5A: 46-64
19. Gupta S, Mehrotra S, Villalón C et al. Effects of female sex hormones on responses to CGRP, acetylcholine, and 5-HT in rat isolated arteries. Headache 2007; 47: 564-75.
20. Lee K, Jeong J, Tsai MJ, Tsai S, Lydon JP, DeMayo FJ. Molecular mechanisms involved in progesterone receptor regulation of uterine function. J Steroid Biochem Mol Biol 2006; 102: 41-50.
21. Costa C, Incio J, Soares R. Angiogenesis and chronic inflammation: cause or consequence? Angiogenesis 2007; 10: 149-66.
22. Soares R, Balogh G, Guo S, Gärtner F, Russo J, Schmitt F. Evidence for the notch signaling pathway on the role of estrogen in angiogenesis. Mol Endocrinol 2004; 18: 2333-43.
23. Soares R, Guo S, Gärtner F, Schmitt FC, Russo J. 17 beta - estradiol-mediated vessel assembly and stabilization in tumor angiogenesis requires TGF beta and EGFR crosstalk. Angiogenesis 2003; 6: 271-81.
24. Rocha A, Azevedo I, Soares R. Anti-angiogenic effects of imatinib target smooth muscle cells but not endothelial cells. Angiogenesis 2007; 10: 279-86.
25. Soares R, Guerreiro S, Botelho M. Elucidating progesterone effects in breast cancer: cross talk with PDGF signaling pathway in smooth muscle cell. J Cell Biochem 2007; 100: 174-83.
26. Katiyar P, Ma Y, Fan S, Pestell RG, Furth PA, Rosen EM. Regulation of progesterone receptor signaling by BRCA1 in mammary cancer. Nucl Recept Signal 2006; 4: e006.
27. Mendelson CR, Hardy DB. Role of the progesterone receptor in the regulation of inflammatory response pathways and aromatase in breast. J Steroid Biochem Mol Biol 2006; 102: 241-9.
28. Nilsen J, Deng J, Brinton RD. Impact of clinically relevant progestins on the neural effects of estradiol and the signaling pathways involved. Drug News Perspect 2005; 18: 545-53.
29. Pike MC, Ross RK. Progestins and menopause: epidemiological studies of risks of endometrial and breast cancer. Steroids 2000; 65: 659-64.
30. Sitruk-Ware R, Plu-Bureau G. Exogenous progestagens and the human breast. Maturitas 2004; 49: 58-66.
31. Tewari M, Pradhan S, Singh U, Shukla HS. Estrogen and progesterone receptor status in breast cancer: Effect of oral contraceptive pills and hormone replacement therapy. Breast 2007; 16: 540-5.
32. Gentilini D, Busacca M, Di Fransesco S, Vignali M, Vigano P, Di Blasio AM. PI3K/Akt and ERK1/2 signalling pathways are invloved in endometrial cell migration induced by 17β-estradiol and growth factors. Mol Human Reprod 2007; 13: 317-22.
33. Ito K. Hormone replacement therapy and cancers: the biological roles of estrogen and progestin in tumorigenesis are different between the endometrium and breast. Tohoku J Exp Med 2007; 212: 1-12
34. kip1 in the normal and malignant endometrium. Cancer Res 2007; 67: 1007-18.
35. Leonhardt SA, Boonyaratanakornkit V, Edwards DP. Progesterone receptor transcription and non-transcription signaling mechanisms. Steroids 2003; 68: 761-70.
36. Li X, O'Malley BW. Unfolding the action of progesterone receptors. J Biol Chem 2003; 278: 39261-4.
37. Boonyaratanakornkit V, McGowan E, Sherman L, Mancini MA, Cheskis BJ, Edwards DP. The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycle. Mol Endocrinol 2007; 21: 359-75.
38. Moore NL, Narayanan R, Weigel NL. Cyclin dependent kinase 2 and the regulation of human progesterone receptor activity. Steroids 2007; 72: 202-9.
39. Skildum A, Faivre E, Lange C. Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinases. Mol Endocrinol 2005; 19: 327-39.
40. Faivre E, Daniel A, Hillard C, Lange C. Progesterone receptor rapid signaling mediates Ser345 phosphorylation and tethering to Sp1 transcription factors. Mol Endocrinol 2008; 22: 823-37.
41. Koulen P, Madry C, Duncan RS, et al. Progesterone potentiates IP(3)-mediated calcium signaling through Akt/PKB. Cell Physiol Biochem 2008; 21: 161-72.
42. Boonyaratanakornkit V, Scott M, Ribon V, et al. Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases. Mol Cell 2001; 8: 269-80.
43. Kampa M, Castanas E. Membrane steroid receptor signaling in normal and neoplastic cells. Mol Cell Endocrinol 2006; 246: 76-82.
44. Gavrilova-Jordan LP, Price TM. Actions of steroids in mithocondria. Semin Reprod Med 2007; 25: 154-64.