Concomitant administration of low dose prednisolone protects against in vivo β2-adrenoceptor subsensitivity induced by regular formoterol

Chest

Volumn 113, Issue 1, 1998, Pages 34-41

  Tan, Kia Soong ^a   McFarlane, Lesley C ^a   Lipworth, Brian J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Corticosteroid; Prednisolone; Subsensitivity formoterol; 2 adrenoceptor

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; CYCLIC AMP; FORMOTEROL FUMARATE; ISOPRENALINE; PLACEBO; PREDNISOLONE; SALBUTAMOL;

ADRENERGIC SYSTEM; ADULT; AREA UNDER THE CURVE; ARTICLE; BRONCHODILATATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CROSSOVER PROCEDURE; DESENSITIZATION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; HEART RATE; HUMAN; HUMAN CELL; INHALATIONAL DRUG ADMINISTRATION; MALE; METERED DOSE INHALER; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECEPTOR DOWN REGULATION;

EID: 6844258871     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.113.1.34     Document Type: Article

References (23)

1. 2-agonists in the management of asthma. Drug Safety 1996; 7:54-70
2. 2-adrenoceptor agonists: time for reappraisal. Br J Clin Pharmacol 1995; 39:109-18
3. Grove A, Lipworth BJ. Bronchodilator subsensitivity to salbutamol after twice-daily salmeterol in asthmatic patients. Lancet 1995; 346:201-06
4. Newnham DM, McDevitt DG, Lipworth BJ. Bronchodilator snbsensitivity after chronic dosing with eformoterol in patients with asthma. Am J Med 1994; 97:29-37
5. 2-adrenoceptor responses after regular twice daily treatment with eformoterol dry powder in asthmatic patients. Thorax 1995; 50:497-504
6. 2-adrenoceptor function in asthmatic patients. Chest 1996; 109:343-47
7. 2-adrenoceptors in asthmatic patients [abstract]. Br J Clin Pharmacol 1996; 42:659P
8. Holgate ST, Baldwin CJ, Tattersfield AE. Beta-adrenergic agonist resistance in normal human airways. Lancet 1977; 1:375-77
9. Ellul-Micallef R, Fenech FF. Effect of intravenous prednisolone in asthmatics with diminished adrenergic responsiveness. Lancet 1975; 2:1269-70
10. Hui KKD, Connolly ME, Tashkin DP. Reversal of human lymphocyte beta-adrenoceptor desensitization by glucocorticoids. Clin Pharmacol Ther 1982; 32:566-71
11. 2-adrenoceptor responsiveness by prednisone and ketotifen. J Clin Invest 1985; 76:1096-1101
12. 2-bronchodilators. Eur J Clin Pharmacol 1988; 34:145-50
13. 2-receptors in rat [abstract]. Am Rev Respir Dis 1993; 147:A275
14. 2-adrenergic receptors in vivo. J Clin Invest 1995; 96:99-106
15. Samuelson WM, Davies AO. Hydrocortisone induced reversal of the beta-adrenergic receptor uncoupling. Am Rev Respir Dis 1984; 130:1023-26
16. Tan KS, Grove A, Maclean A, et al. Systemic corticosteroid rapidly reverses bronchodilator subsensitivity induced by formoterol in asthmatic patients. Am J Respir Crit Care Med 1997; 156:28-35
17. 2-Adrenoceptors in human lung and peripheral mononuclear leukocytes of untreated and terbutaline-treated patients. Chest 1990; 98: 376-81
18. Hayes MJ, Quing F, Rhodes CG, et al. In vivo quantification of human pulmonary β-adrenoceptors: effect of β-agonist therapy. Am J Respir Crit Care Med 1996; 154:1277-83
19. Davies AO, Lefkowitz RJ. Regulation of β-adrenergic receptors by steroid hormones. Ann Rev Physiol 1984; 46:119-30
20. Collins S, Caron MG, Lefkowitz RJ. β-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids. J Biol Chem 1988; 263:9067-70
21. Mak JCW, Nishikawa M, Barnes PJ. Glucocorticosteroids increase β-adrenergic receptor transcription in human lung. Am J Physiol 1995; 12:141-46
22. Davies AO, Lefkowitz RJ. Agonist promoted high affinity state of the β-adrenergic receptor in human neutrophils: modulation-by corticusteroids. J Clin Endocrinol Metab 1980; 53:703-38
23. Davies AO, Lefkowitz KJ. In-vitro desensitization of beta adrenergic receptors in human neutrophils: attenuation by eorticosteroids. J Clin Invest 1983; 71:565-71