Use of azathioprine and 6MP in postoperative Crohn's: Changing natural history or just along for the ride

American Journal of Gastroenterology

Volumn 104, Issue 8, 2009, Pages 2097-2099

  Velayos, Fernando S ^b   Sandborn, William J ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; BUDESONIDE; INFLIXIMAB; MERCAPTOPURINE; MESALAZINE; METRONIDAZOLE; NITROIMIDAZOLE; ORNIDAZOLE; PLACEBO; PREDNISONE; SALAZOSULFAPYRIDINE;

CLINICAL TRIAL; CROHN DISEASE; DRUG EFFICACY; HUMAN; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RECURRENT DISEASE; REVIEW;

6-MERCAPTOPURINE; AZATHIOPRINE; CROHN DISEASE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; RECURRENCE;

EID: 68349141466     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2009.306     Document Type: Review

References (31)

1. Cosnes J, Cattan S, Blain A et al. Long-term evolution of disease behavior of Crohn's disease. Inflamm Bowel Dis 2002;8:244-50.
2. Rutgeerts P, Geboes K, Vantrappen G et al. Predictability of the postoperative course of Crohn's disease. Gastroenterology 1990;99:956-63.
3. McLeod RS, Wolff BG, Steinhart AH et al. Risk and significance of endoscopic/radiological evidence of recurrent Crohn's disease. Gastroenterology 1997;113:1823-7.
4. Michelassi F, Balestracci T, Chappell R et al. Primary and recurrent Crohn's disease. Experience with 137. patients. Ann Surg 1991;214:230-8. discussion 238-40.
5. Bergman L, Krause U. Postoperative treatment with corticosteroids and salazosulphapyridine (Salazopyrin) after radical resection for Crohn's disease. Scand J Gastroenterol 1976;11:651-6.
6. Smith RC, Rhodes J, Heatley RV et al. Low dose steroids and clinical relapse in Crohn's disease: a controlled trial. Gut 1978;19:606-10.
7. Hellers G, Cortot A, Jewell D et al. Oral budesonide for prevention of postsurgical recurrence in Crohn's disease. The IOIBD Budesonide Study Group. Gastroenterology 1999;116:294-300.
8. Ewe K, Bottger T, Buhr HJ et al. Low-dose budesonide treatment for prevention of postoperative recurrence of Crohn's disease: a multicentre randomized placebo-controlled trial. German Budesonide Study Group. Eur J Gastroenterol Hepatol 1999;11:277-82.
9. Ewe K, Herfarth C, Malchow H et al. Postoperative recurrence of Crohn's disease in relation to radicality of operation and sulfasalazine prophylaxis: a multicenter trial. Digestion 1989;42:224-32.
10. Wenckert A, Kristensen M, Eklund AE et al. The long-term prophylactic effect of salazosulphapyridine (Salazopyrin) in primarily resected patients with Crohn's disease. A controlled double-blind trial. Scand J Gastroenterol 1978;13:161-7.
11. McLeod RS, Wolff BG, Steinhart AH et al. Prophylactic mesalamine treatment decreases postoperative recurrence of Crohn's disease. Gastroenterology 1995;109:404-13.
12. Caprilli R, Andreoli A, Capurso L et al. Oral mesalazine (5-aminosalicylic acid; Asacol) for the prevention of post-operative recurrence of Crohn's disease. Gruppo Italiano per lo Studio del Colone del Retto (GISC). Aliment Pharmacol Ther 1994;8:35-43.
13. Florent C, Cortot A, Quandale P et al. Placebo-controlled clinical trial of mesalazine in the prevention of early endoscopic recurrences after resection for Crohn's disease. Groupe d'Etudes Therapeutiques des Affections Inflammatoires Digestives (GETAID). Eur J Gastroenterol Hepatol 1996;8:229-33.
14. Brignola C, Cottone M, Pera A et al. Mesalamine in the prevention of endoscopic recurrence after intestinal resection for Crohn's disease. Italian Cooperative Study Group. Gastroenterology 1995;108:345-9.
15. Sutherland LR, Martin F, Bailey RJ et al. A randomized, placebo-controlled, double-blind trial of mesalamine in the maintenance of remission of Crohn's disease. The Canadian Mesalamine for Remission of Crohn's Disease Study Group. Gastroenterology 1997;112:1069-77.
16. Lochs H, Mayer M, Fleig WE et al. Prophylaxis of postoperative relapse in Crohn's disease with mesalamine: European Cooperative Crohn's Disease Study VI. Gastroenterology 2000;118:264-73.
17. Rutgeerts P, Hiele M, Geboes K et al. Controlled trial of metronidazole treatment for prevention of Crohn's recurrence after ileal resection. Gastroenterology 1995;108:1617-21.
18. Rutgeerts P, Van Assche G, Vermeire S et al. Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial. Gastroenterology 2005;128:856-61.
19. Hanauer SB, Korelitz BI, Rutgeerts P et al. Postoperative maintenance of Crohn's disease remission with 6-mercaptopurine, mesalamine, or placebo: a 2-year trial. Gastroenterology 2004;127:723-9.
20. D'Haens GR, Vermeire S, Van Assche G et al. Therapy of metronidazole with azathioprine to prevent postoperative recurrence of Crohn's disease: a controlled randomized trial. Gastroenterology 2008;135:1123-9.
21. Ardizzone S, Maconi G, Sampietro GM et al. Azathioprine and mesalamine for prevention of relapse after conservative surgery for Crohn's disease. Gastroenterology 2004;127:730-40.
22. Herfarth H, Tjaden C, Lukas M et al. Adverseevents in clinical trials with azathioprine and mesalamine for prevention of postoperative recurrence of Crohn's disease. Gut 2006;55:1525-6.
23. Regueiro M, Schraut W, Baidoo L et al. Infliximab prevents Crohn's disease recurrence after ileal resection. Gastroenterology 2009;136:441-5. e1. quiz 716.
24. Peyrin-Biroulet L, Deltenre P, Ardizzone S et al. Azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in Crohn's disease: a meta-analysis. Am J Gastroenterol 2009;104:2089-96 (this issue).
25. Rutgeerts P, Geboes K, Vantrappen G et al. Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery. Gut 1984;25:665-72.
26. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-88.
27. Bangalore S, Wetterslev J, Pranesh S et al. Perioperative beta blockers in patients having non-cardiac surgery: a meta-analysis. Lancet 2008;372:1962-76.
28. Figueredo A, Coombes ME, Mukherjee S. Adjuvant therapy for completely resected stage II colon cancer. Cochrane Database Syst Rev 2008; 3. CD005390.
29. Sachar DB, Wolfson DM, Greenstein AJ et al. Risk factors for postoperative recurrence of Crohn's disease. Gastroenterology 1983;85:917-21.
30. Sutherland LR, Ramcharan S, Bryant H et al. Effect of cigarette smoking on recurrence of Crohn's disease. Gastroenterology 1990;98:1123-8.
31. Greenstein AJ, Lachman P, Sachar DB et al. Perforating and non- perforating indications for repeated operations in Crohn's disease: evidence for two clinical forms. Gut 1988;29:588-92.