Human plasma-mediated hypoxic activation of indolequinone-based naloxone pro-drugs

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 17, 2009, Pages 5016-5020

  Huang, Baohua ^a   Tang, Shengzhuang ^a   Desai, Ankur ^a   Cheng, Xue min ^a   Kotlyar, Alina ^a   Spek, Abraham Van Der ^a   Thomas, Thommey P ^a   Baker Jr , James R ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Human plasma; Hypoxia; Indolequinone; Naloxone; Selective drug release

Indexed keywords

INDOLE DERIVATIVE; NALOXONE; NARCOTIC ANTAGONIST; PRODRUG; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ANALGESIA; ARTICLE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG BIOAVAILABILITY; DRUG CONJUGATION; DRUG HYDROLYSIS; DRUG RELEASE; DRUG STABILITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; HYPOXIA; MACROMOLECULE; PLASMA; RESPIRATION DEPRESSION;

BLOOD CELLS; CELL HYPOXIA; HUMANS; INDOLEQUINONES; NAD(P)H DEHYDROGENASE (QUINONE); NALOXONE; NARCOTIC ANTAGONISTS; PRODRUGS;

EID: 68349135127     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.061     Document Type: Article

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