Aquilegia vulgaris extract attenuates carbon tetrachloride-induced liver fibrosis in rats

Experimental and Toxicologic Pathology

Volumn 61, Issue 5, 2009, Pages 443-451

  Jodynis Liebert, Jadwiga ^a   Adamska, Teresa ^a   Ewertowska, Małgorzata ^a   Bylka, Wiesława ^a   Matławska, Irena ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Antioxidant enzymes; Aquilegia vulgaris; Hydroxyproline; Lipid peroxidation; Liver cirrhosis; Liver fibrosis; Rat

Indexed keywords

AQUILEGIA VULGARIS EXTRACT; BILIRUBIN; CARBON TETRACHLORIDE; CHOLESTEROL; GLUTATHIONE; HYDROXYPROLINE; LIVER ENZYME; PLANT EXTRACT; SILYMARIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; AQUILEGIA; AQUILEGIA VULGARIS; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; HISTOPATHOLOGY; LIPID PEROXIDATION; LIVER FIBROSIS; LIVER LEVEL; MALE; NONHUMAN; RAT;

ANIMALS; AQUILEGIA; CARBON TETRACHLORIDE; FIBROSIS; GLUTATHIONE; HYDROXYPROLINE; LIPID PEROXIDATION; LIVER DISEASES; MALE; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR; SILYMARIN;

ANIMALIA; AQUILEGIA VULGARIS; RATTUS; RATTUS NORVEGICUS;

EID: 68349127172     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2008.10.007     Document Type: Article

References (36)

1. Abul H., Mathew T.C., Dashti H.M., and Al-Bader A. Level of superoxide dismutase, glutathione peroxidase and uric acid in thioacetamide-induced cirrhotic rats. Anat Histol Embryol 31 (2002) 66-71
2. Adamska T., Młynarczyk W., Jodynis-Liebert J., Bylka W., and Matławska I. Hepatoprotective effect of the extract and isocytisoside from Aquilegia vulgaris. Phytother Res 17 (2003) 691-696
3. Beer R.F., and Sizer I.W. A spectrophotometric method measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 195 (1952) 133-140
4. Bruck R., Shirin H., Aeed H., Matas Z., Hochman A., Pines M., et al. Prevention of hepatic cirrhosis in rats by hydroxyl radical scavengers. J Hepatol 35 (2001) 457-464
5. Bylka W. Isovitexin O-glucosides from Aquilegia vulgaris L. Acta Pol Pharm 58 (2001) 273-275
6. Bylka W., and Matławska I. Flavonoids from Aquilegia vulgaris L. Part I. Isocytisoside and its glycosides. Acta Pol Pharm 54 (1997) 331-333
7. Bylka W., and Matławska I. Flavonoids from Aquilegia vulgaris L. Part II. Derivatives of apigenin and luteolin. Acta Pol Pharm 54 (1997) 331-337
8. Bylka W., Frański R., and Stobiecki M. Differentiation between isomeric acacetin-6-C-(6″-O-malonyl) glucoside and acacetin-8-C-(6″-O-malonyl) glucoside by using lower energy CID mass spectra. J Mass Spectrom 37 (2002) 648-650
9. Cabre M., Camps J., Paternain J.L., Ferre N., and Joven J. Time-course of changes in hepatic lipid peroxidation and glutathione metabolism in rats with carbon tetrachloride-induced cirrhosis. Clin Exp Pharmacol Physiol 27 (2000) 694-699
10. Campo G.M., Avenoso A., Campo S., D'Ascola A., Ferlazzo A.M., and Calatroni A. The antioxidant and antifibrogenic effects of the glycosaminoglycans hyaluronic acid and chondroitin-4-sulphate in a subchronic rat model of carbon tetrachloride-induced liver fibrogenesis. Chem Biol Interact 148 (2004) 125-138
11. Das D., Pemberton P.W., Burrows P.C., Gordon C., Smith A., McMahon R.F., et al. Antioxidant properties of colchicine in acute carbon tetrachloride induced rat liver injury and its role in the resolution of established cirrhosis. Biochim Biophys Acta 1502 (2000) 351-362
12. DeLeve L.D., and Kaplowitz N. Importance and regulation of hepatic glutathione. Semin Liver Dis 10 (1990) 251-266
13. Drost-Karbowska K., Szaufer-Hajdrych M., Kowalewski Z., and Zgórka G. Phenolic acids in Aquilegia vulgaris (Ranuculaceae). Herba Pol 42 (1996) 21-24
14. Gebhardt R. Oxidative stress, plant-derived antioxidants and liver fibrosis. Planta Med 68 (2002) 289-296
15. Gonzalez-Correa J.A., de la Cruz J.P., Gordillo J., Urena I., Redondo L., and Sanchez de la Cuesta F. Effects of silymarin MZ-80 on hepatic oxidative stress in rats with biliary obstruction. Pharmacology 64 (2002) 18-27
16. Guo M.Z., Li X.S., Xu H.R., Mei Z.C., Shen W., and Ye X.F. Rhein inhibits liver fibrosis induced by carbon tetrachloride in rats. Acta Pharmacol Sin 23 (2002) 739-744
17. Halliwell B., and Gutteridge J.M. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 219 (1984) 1-14
18. Hsiao G., Lin Y.H., Lin C.H., Chou D.S., Lin W.C., and Sheu J.R. The protective effects of PMC against chronic carbon tetrachloride-induced hepatotoxicity in vivo. Biol Pharm Bull 24 (2001) 1271-1276
19. Jamall I.S., Finelli V.N., and Que Hee S.S. A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues. Anal Biochem 112 (1981) 70-75
20. Jodynis-Liebert, Matławska I., Bylka W., and Murias M. Protective effect of Aquilegia vulgaris (L.) on APAP-induced oxidative stress in rats. J Ethnopharm 97 (2005) 351-358
21. 4-treated rats. J Vet Med A Physiol Pathol Clin Med 50 (2003) 264-268
22. Lee D.H., Blomhoff R., and Jacobs Jr. D.R. Is serum gamma glutamyltransferase a marker of oxidative stress?. Free Radic Res 38 (2004) 535-539
23. Liu P., Hu Y., Liu C., Liu C., and Zhu D. Effects of salviainolic acid A (SA-A) on liver injury: SA-A action on hepatic peroxidation. Liver 21 (2001) 384-390
24. Lu G., Shimizu I., Cui X., Itonaga M., Tamaki K., Fukuno H., et al. Antioxidant and antiapoptotic activities of idoxifene and estradiol in hepatic fibrosis in rats. Life Sci 74 (2004) 897-907
25. Mohandas J., Marshall J.J., Duggin G.G., Horvath J.S., and Tiller D.J. Low activities of glutathione-related enzymes as factors in the genesis of urinary bladder cancer. Cancer Res 44 (1984) 5086-5091
26. Nan J.X., Park E.J., Kim Y.C., Ko G., and Sohn D.H. Scutellaria baicalensis inhibits liver fibrosis induced by bile duct ligation or carbon tetrachloride in rats. J Pharm Pharmacol 54 (2002) 555-563
27. Park E.J., Nan J.X., Kim J.Y., Kang H.C., Choi J.H., Lee S.J., et al. The ethanol-soluble part of a hot-water extract from Artemisia iwayomogi inhibits liver fibrosis induced by carbon tetrachloride in rats. J Pharm Pharmacol 52 (2000) 875-881
28. Pavanato A., Tunon M.J., Sanchez-Campos S., Marroni C.A., Llesuy S., Gonzalez-Gallego J., et al. Effects of quercetin on liver damage in rats with carbon tetrachloride-induced cirrhosis. Dig Dis Sci 48 (2003) 824-849
29. PDR for herbal medicines. 2nd ed. (2000), Medical Economics Company Montreal, New Jersey p. 211-2
30. Peres W., Tunon M.J., Collado P.S., Herrmann S., Marroni N., and Gonzalez-Gallego J. The flavonoid quercetin ameliorates liver damage in rats with biliary obstruction. J Hepatol 33 (2000) 742-750
31. Poli G., and Parola M. Oxidative damage and fibrogenesis. Free Radic Biol Med 22 (1997) 287-305
32. Sanz M.J., Ferrandiz M.L., Cejudo M., Terencio M.C., Gil B., Bustos G., et al. Influence of a series of natural flavonoids on free radical generating systems and oxidative stress. Xenobiotica 24 (1994) 689-699
33. Sedlak J., and Lindsay R.H. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 25 (1968) 192-205
34. Stickel F., Brinkhaus B., Krahmer N., Seitz H.K., Hahn E.G., and Schuppan D. Antifibrotic properties of botanicals in chronic liver disease. Hepatogastroenterology 49 (2002) 1102-1108
35. Sun M., and Zigman S. An improved spectrophotometric assay for superoxide dismutase based on epinephrine autoxidation. Anal Biochem 90 (1978) 81-89
36. Szaufer-Hajdrych M., Drost-Karbowska H., and Kowalewski Z. Phenolic acids and alkaloids in the roots of Aquilegia vulgaris. Herba Pol 44 (1998) 195-199