Breaking down barriers: The importance of the stromal microenvironment in acquiring invasiveness in young women's breast cancer

Breast Cancer Research

Volumn 11, Issue 2, 2009, Pages

  Schedin, Pepper ^a,b,c,d   Borges, Virginia ^a,b,c  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO CANCER CENTER   (United States)

^c UNIVERSITY OF COLORADO HOSPITAL   (United States)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER; BREAST EPITHELIUM; CANCER INVASION; CANCER PATIENT; CLINICAL ARTICLE; CONTROLLED STUDY; EDITORIAL; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HUMAN TISSUE; INTRADUCTAL CARCINOMA; METASTASIS; PHENOTYPE; STROMA; TUMOR MICROENVIRONMENT; ATYPICAL DUCTAL HYPERPLASIA; BREAST CARCINOGENESIS; BREAST CARCINOMA; BREAST CARCINOMA IN SITU; CANCER GENETICS; CANCER PROGNOSIS; DISEASE ACTIVITY; MALIGNANT TRANSFORMATION; METASTASIS POTENTIAL; METASTATIC BREAST CANCER; TUMOR INVASION; BREAST TUMOR; DISEASE COURSE; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; NOTE; PAGET NIPPLE DISEASE; PATHOLOGY; PHYSIOLOGY; STROMA CELL;

BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, INTRADUCTAL, NONINFILTRATING; DISEASE PROGRESSION; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM INVASIVENESS; STROMAL CELLS;

EID: 68349109805     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2235     Document Type: Editorial

References (15)

1. Ma XJ, Dahiya S, Richardson E, Erlander M, Sgroi DC. Gene expression profiling of the tumor microenvironment during breast cancer progression. Breast Cancer Res 2009, 11:R7. 10.1186/bcr2222, 19187537.
2. Ma XJ, Salunga R, Tuggle JT, Gaudet J, Enright E, McQuary P, Payette T, Pistone M, Stecker K, Zhang BM, Zhou YX, Varnholt H, Smith B, Gadd M, Chatfield E, Kessler J, Baer TM, Erlander MG, Sgroi DC. Gene expression profiles of human breast cancer progression. Proc Natl Acad Sci USA 2003, 100:5974-5979. 156311, 12714683, 10.1073/pnas.0931261100.
3. van 't Veer LJ, Dai H, Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, Kooy K, Marton MJ, Witteveen AT, Schreiber GJ, Kerkhoven RM, Roberts C, Linsley PS, Bernards R, Friend SH. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002, 415:530-536. 10.1038/415530a, 11823860.
4. Bernards R, Weinberg RA. A progression puzzle. Nature 2002, 418:823. 10.1038/418823a, 12192390.
5. Paik S, Shak S, Tang G, Kim C, Baker J, Cronin M, Baehner FL, Walker MG, Watson D, Park T, Hiller W, Fisher ER, Wickerham DL, Bryant J, Wolmark N. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 2004, 351:2817-2826. 10.1056/NEJMoa041588, 15591335.
6. Schedin P, Elias A. Multistep tumorigenesis and the microenvironment. Breast Cancer Res 2004, 6:93-101. 400664, 14979914, 10.1186/bcr772.
7. Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H, Porter D, Hu M, Chin L, Richardson A, Schnitt S, Sellers WR, Polyak K. Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 2004, 6:17-32. 10.1016/j.ccr.2004.06.010, 15261139.
8. Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K, Chi JT, Rijn M, Botstein D, Brown PO. Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. PLoS Biol 2004, 2:E7. 314300, 14737219, 10.1371/journal.pbio.0020007.
9. Beck AH, Espinosa I, Edris B, Li R, Montgomery K, Zhu S, Varma S, Marinelli RJ, Rijn M, West RB. The macrophage colony-stimulating factor 1 response signature in breast carcinoma. Clin Cancer Res 2009, 15:778-787. 10.1158/1078-0432.CCR-08-1283, 19188147.
10. Beck AH, Espinosa I, Gilks CB, Rijn M, West RB. The fibromatosis signature defines a robust stromal response in breast carcinoma. Lab Invest 2008, 88:591-601. 10.1038/labinvest.2008.31, 18414401.
11. Egeblad M, Littlepage LE, Werb Z. The fibroblastic coconspirator in cancer progression. Cold Spring Harb Symp Quant Biol 2005, 70:383-388. 2580828, 16869775, 10.1101/sqb.2005.70.007.
12. Mueller MM, Fusenig NE. Friends or foes - bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 2004, 4:839-849. 10.1038/nrc1477, 15516957.
13. Barkan D, Kleinman H, Simmons JL, Asmussen H, Kamaraju AK, Hoenorhoff MJ, Liu ZY, Costes SV, Cho EH, Lockett S, Khanna C, Chambers AF, Green JE. Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton. Cancer Res 2008, 68:6241-6250. 10.1158/0008-5472.CAN-07-6849, 18676848.
14. Albini A, Mirisola V, Pfeffer U. Metastasis signatures: genes regulating tumor-microenvironment interactions predict metastatic behavior. Cancer Metastasis Rev 2008, 27:75-83. 10.1007/s10555-007-9111-x, 18046511.
15. DeNardo DG, Johansson M, Coussens LM. Immune cells as mediators of solid tumor metastasis. Cancer Metastasis Rev 2008, 27:11-18. 10.1007/s10555-007-9100-0, 18066650.