Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase

Analytical and Bioanalytical Chemistry

Volumn 394, Issue 7, 2009, Pages 1903-1909

  Shi, Zhen Dan ^b   Motabar, Omid ^a   Goldin, Ehud ^a   Liu, Ke ^a   Southall, Noel ^a   Sidransky, Ellen ^a   Austin, Christopher P ^a   Griffiths, Gary L ^b   Zheng, Wei ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Alpha galactosidase; Assay miniaturization; Assay optimization; Enzyme assay; Fabry disease

Indexed keywords

ALPHA-GALACTOSIDASE; ASSAY OPTIMIZATION; BLUE FLUORESCENCE; ENZYME ASSAY; ENZYME ASSAYS; FABRY DISEASE; FLUOROGENIC SUBSTRATE; GALACTOPYRANOSIDE; GALACTOSIDASES; GLOBOTRIAOSYLCERAMIDE; GLYCOLIPIDS; GLYCOSPHINGOLIPIDS; HIGH-THROUGHPUT SCREENING; MISFOLDING; MUTANT ENZYMES; PH VALUE; POTENTIAL THERAPIES; RED FLUORESCENCE; RESORUFIN; SMALL MOLECULES; SYNTHESIS AND CHARACTERIZATION;

FLUORESCENCE; MINIATURE INSTRUMENTS; RAMAN SPECTROSCOPY; SUBSTRATES; SYNTHESIS (CHEMICAL);

ENZYMES;

1 DEOXYNOJIRIMYCIN; 1-DEOXYGALACTONOJIRIMYCIN; ALPHA GALACTOSIDASE; DRUG DERIVATIVE; FLUORESCENT DYE; GALACTOSIDE; MIGALASTAT; OXAZINE DERIVATIVE; RESORUFIN; RESORUFINYL ALPHA D GALACTOPYRANOSIDE; RESORUFINYL ALPHA-D-GALACTOPYRANOSIDE;

ARTICLE; CHEMISTRY; DRUG ANTAGONISM; FLUORESCENCE; KINETICS; METABOLISM; PH; SENSITIVITY AND SPECIFICITY; SYNTHESIS; THIN LAYER CHROMATOGRAPHY;

1-DEOXYNOJIRIMYCIN; ALPHA-GALACTOSIDASE; CHROMATOGRAPHY, THIN LAYER; FLUORESCENCE; FLUORESCENT DYES; GALACTOSIDES; HYDROGEN-ION CONCENTRATION; KINETICS; OXAZINES; SENSITIVITY AND SPECIFICITY;

EID: 68349098956     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-009-2879-5     Document Type: Article

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