Physical activity increases bone mass during growth

Food and Nutrition Research

Volumn 52, Issue , 2008, Pages

  Karlsson, Magnus K ^a   Nordqvist, Anders ^a   Karlsson, Caroline ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Bone mass; Bone mineral content, BMC; Bone mineral density, BMD; Exercise; Growth; Nutrition; Physical activity; Skeletal structure

Indexed keywords

EID: 68249152770     PISSN: 16546628     EISSN: None     Source Type: Journal    
DOI: 10.3402/fnr.v52i0.1871     Document Type: Review

References (105)

1. Cooper C, Campion G, Melton LJ, 3rd. Hip fractures in the elderly: a world-wide projection. Osteoporos Int 1992; 2: 285-9.
2. Cooper C, Melton LJ, 3rd. Magnitude and impact of osteoporosis and fractures. In: Marcus R, Feldman D, Kelsey J, eds. Osteoporosis. San Diego, CA: Academic Press; 1996. p. 419-34.
3. Johnell O, Gullberg B, Kanis JA, Allander E, Elffors L, Dequeker J, et al. Risk factors for hip fracture in European women: the MEDOS Study. Mediterranean Osteoporosis Study. J Bone Miner Res 1995; 10: 1802-15.
4. Jonsson B. Life style and fracture risk. Thesis. Sweden: University of Lund; 1993.
5. Kanis JA, Oden A, Johnell O, Jonsson B, de Laet C, Dawson A. The burden of osteoporotic fractures: a method for setting intervention thresholds. Osteoporos Int 2001; 12: 417-27. (Pubitemid 32606468)
6. Kannus P, Niemi S, Parkkari J, Palvanen M, Vuori I, Jarvinen M. Hip fractures in Finland between 1970 and 1997 and predictions for the future. Lancet 1999; 353: 802-5. (Pubitemid 29110406)
7. Kannus P, Parkkari J, Sievanen H, Heinonen A, Vuori I, Jarvinen M. Epidemiology of hip fractures. Bone 1996; 18(Suppl 1): 57S-63S. (Pubitemid 26047545)
8. Melton LJ, 3rd, Atkinson EJ, Madhok R. Downturn in hip fracture incidence. Public Health Rep 1996; 111: 146-50; discussion 151.
9. Melton LJ, 3rd, Lane AW, Cooper C, Eastell R, O'Fallon WM, Riggs BL. Prevalence and incidence of vertebral deformities. Osteoporos Int 1993; 3: 113-9. (Pubitemid 23125371)
10. Bengner U. Epidemiological changes over 30 years in an urban population. Thesis. Sweden: University of Lund; 1987.
11. Gullberg B, Duppe H, Nilsson B, Redlund-Johnell I, Sernbo I, Obrant K, et al. Incidence of hip fractures in Malmo, Sweden (1950-1991). Bone 1993; 14(Suppl 1): S23-9. (Pubitemid 23361513)
12. Gullberg B, Johnell O, Kanis JA. World-wide projections for hip fracture. Osteoporos Int 1997; 7: 407-13. (Pubitemid 27443065)
13. Cummings SR, Kelsey JL, Nevitt MC, O'Dowd KJ. Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev 1985; 7: 178-208. (Pubitemid 15236006)
14. Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet 2002; 359: 1761-7.
15. Obrant KJ, Bengner U, Johnell O, Nilsson BE, Sernbo I. Increasing age-adjusted risk of fragility fractures: a sign of increasing osteoporosis in successive generations? Calcif Tissue Int 1989; 44: 157-67. (Pubitemid 19076622)
16. Cooper C, Atkinson EJ, Jacobsen SJ, O'Fallon WM, Melton LJ, 3rd. Population-based study of survival after osteoporotic fractures. Am J Epidemiol 1993; 137: 1001-5. (Pubitemid 23191067)
17. Kanis JA, Oden A, Johnell O, Johansson H, De Laet C, Brown J, et al. The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int 2007; 18: 1033-46. (Pubitemid 47020000)
18. Ahlborg H, Johnell O, Järvinen T, Karlsson MK. Prevalence of low bone mass in women - secular trend over 30 years. J Bone Miner Res 2004; 19(Supp1): S49.
19. Hui SL, Slemenda CW, Johnston CC, Jr. The contribution of bone loss to postmenopausal osteoporosis. Osteoporos Int 1990; 1(Suppl 1): 30-4.
20. Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, et al. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 1995; 332: 767-73.
21. Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 1996; 312: 1254-9. (Pubitemid 26147662)
22. Ahlborg HG, Johnell O, Turner CH, Rannevik G, Karlsson MK. Bone loss and bone size after menopause. N Engl J Med 2003; 349: 327-34. (Pubitemid 36886238)
23. Jarvinen TL, Sievanen H, Khan KM, Heinonen A, Kannus P. Shifting the focus in fracture prevention from osteoporosis to falls. BMJ 2008; 336: 124-6. (Pubitemid 351211962)
24. Karlsson M, Bass S, Seeman E. The evidence that exercise during growth or adulthood reduces the risk of fragility fractures is weak. Baillieres Best Pract Res Clin Rheumatol 2001; 15: 429-50. (Pubitemid 32755093)
25. Nilsson BE, Westlin NE. Bone density in athletes. Clin Orthop 1971; 77: 179-82.
26. Hind K, Burrows M. Weight-bearing exercise and bone mineral accrual in children and adolescents: a review of controlled trials. Bone 2007; 40: 14-27. (Pubitemid 44848417)
27. Jones HH, Priest JD, Hayes WC, Tichenor CC, Nagel DA. Humeral hypertrophy in response to exercise. J Bone Joint Surg [Am] 1977; 59: 204-8. (Pubitemid 8067255)
28. Huddleston AL, Rockwell D, Kulund DN, Harrison RB. Bone mass in lifetime tennis athletes. JAMA 1980; 244: 1107-9. (Pubitemid 10035591)
29. Bass SL, Saxon L, Daly RM, Turner CH, Robling AG, Seeman E, et al. The effect of mechanical loading on the size and shape of bone in pre-, peri-, and postpubertal girls: a study in tennis players. J Bone Miner Res 2002; 17: 2274-80. (Pubitemid 35416762)
30. Kannus P, Haapasalo H, Sankelo M, Sievanen H, Pasanen M, Heinonen A, et al. Effect of starting age of physical activity on bone mass in the dominant arm of tennis and squash players. Ann Intern Med 1995; 123: 27-31.
31. Karlsson MK, Hasserius R, Obrant KJ. Bone mineral density in athletes during and after career: a comparison between loaded and unloaded skeletal regions. Calcif Tissue Int 1996; 59: 245-8. (Pubitemid 26353017)
32. Karlsson MK, Johnell O, Obrant KJ. Bone mineral density in weight lifters. Calcif Tissue Int 1993; 52: 212-5. (Pubitemid 23090714)
33. Karlsson MK, Johnell O, Obrant KJ. Bone mineral density in professional ballet dancers. Bone Miner 1993; 21: 163-9. (Pubitemid 23262987)
34. Karlsson MK, Linden C, Karlsson C, Johnell O, Obrant K, Seeman E. Exercise during growth and bone mineral density and fractures in old age. Lancet 2000; 355: 469-70. (Pubitemid 30085162)
35. Karlsson MK, Magnusson H, Karlsson C, Seeman E. The duration of exercise as a regulator of bone mass. Bone 2001; 28: 128-32. (Pubitemid 32112072)
36. Duppe H, Gardsell P, Johnell O, Ornstein E. Bone mineral density in female junior, senior and former football players. Osteoporos Int 1996; 6: 437-41. (Pubitemid 27007696)
37. Valdimarsson O, Alborg HG, Duppe H, Nyquist F, Karlsson M. Reduced training is associated with increased loss of BMD. J Bone Miner Res 2005; 20: 906-12. (Pubitemid 40712813)
38. Valdimarsson O, Sigurdsson G, Steingrimsdottir L, Karlsson MK. Physical activity in the post-pubertal period is associated with maintenance of pre-pubertal high bone density - a 5-year follow-up. Scand J Med Sci Sports 2005; 15: 280-6. (Pubitemid 41426402)
39. Bass S, Pearce G, Bradney M, Hendrich E, Delmas PD, Harding A, et al. Exercise before puberty may confer residual benefits in bone density in adulthood: studies in active prepubertal and retired female gymnasts. J Bone Miner Res 1998; 13: 500-7.
40. Karlsson MK, Vergnaud P, Delmas PD, Obrant KJ. Indicators of bone formation in weight lifters. Calcif Tissue Int 1995; 56: 177-80.
41. Kontulainen S, Sievanen H, Kannus P, Pasanen M, Vuori I. Effect of long-term impact-loading on mass, size, and estimated strength of humerus and radius of female racquet-sports players: a peripheral quantitative computed tomography study between young and old starters and controls. J Bone Miner Res 2002; 17: 2281-9. (Pubitemid 35416763)
42. Specker B, Binkley T. Randomized trial of physical activity and calcium supplementation on bone mineral content in 3- to 5- year-old children. J Bone Miner Res 2003; 18: 885-92. (Pubitemid 37294972)
43. Lanyon LE. Control of bone architecture by functional load bearing. J Bone Miner Res 1992; 7(Suppl 2): S369-75. (Pubitemid 23020195)
44. Rubin CT, Lanyon LE. Regulation of bone formation by applied dynamic loads. J Bone Joint Surg [Am] 1984; 66: 397-402. (Pubitemid 14169460)
45. Rubin CT, Lanyon LE. Regulation of bone mass by mechanical strain magnitude. Calcif Tissue Int 1985; 37: 411-7. (Pubitemid 15015324)
46. Turner CH, Woltman TA, Belongia DA. Structural changes in rat bone subjected to long-term, in vivo mechanical loading. Bone 1992; 13: 417-22.
47. Cullen DM, Smith RT, Akhter MP. Bone-loading response varies with strain magnitude and cycle number. J Appl Physiol 2001; 91: 1971-6. (Pubitemid 33015044)
48. Hsieh YF, Turner CH. Effects of loading frequency on mechanically induced bone formation. J Bone Miner Res 2001; 16: 918-24. (Pubitemid 32332302)
49. Umemura Y, Ishiko T, Yamauchi T, Kurono M, Mashiko S. Five jumps per day increase bone mass and breaking force in rats. J Bone Miner Res 1997; 12: 1480-5. (Pubitemid 27375392)
50. Lanyon LE, Rubin CT. Static vs dynamic loads as an influence on bone remodelling. J Biomech 1984; 17: 897-905. (Pubitemid 15166456)
51. Robling AG, Burr DB, Turner CH. Recovery periods restore mechanosensitivity to dynamically loaded bone. J Exp Biol 2001; 204(Pt 19): 3389-99. (Pubitemid 34861350)
52. Robling AG, Hinant FM, Burr DB, Turner CH. Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts. J Bone Miner Res 2002; 17: 1545-54. (Pubitemid 34803837)
53. Robling AG, Hinant FM, Burr DB, Turner CH. Shorter, more frequent mechanical loading sessions enhance bone mass. Med Sci Sports Exerc 2002; 34: 196-202. (Pubitemid 34132020)
54. Srinivasan S, Agans SC, King KA, Moy NY, Poliachik SL, Gross TS. Enabling bone formation in the aged skeleton via rest-inserted mechanical loading. Bone 2003; 33: 946-55. (Pubitemid 37543571)
55. Srinivasan S, Weimer DA, Agans SC, Bain SD, Gross TS. Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle. J Bone Miner Res 2002; 17: 1613-20.
56. Michel BA, Lane NE, Bjorkengren A, Bloch DA, Fries JF. Impact of running on lumbar bone density: a 5-year longitudinal study. J Rheumatol 1992; 19: 1759-63.
57. Alwis G, Linden C, Dencker M, Stenevi-Lundgren S, Gardsell P, Karlsson MK. Bone mineral accrual and gain in skeletal width in pre-pubertal school children is independent of the mode of school transportation-one-year data from the prospective observational pediatric osteoporosis prevention (POP) study. BMC Musculoskelet Disord 2007; 8: 66.
58. Blimkie CJ, Rice S, Webber CE, Martin J, Levy D, Gordon CL. Effects of resistance training on bone mineral content and density in adolescent females. Can J Physiol Pharmacol 1996; 74: 1025-33.
59. Bradney M, Pearce G, Naughton G, Sullivan C, Bass S, Beck T, et al. Moderate exercise during growth in prepubertal boys: changes in bone mass, size, volumetric density, and bone strength: a controlled prospective study [see comments]. J Bone Miner Res 1998; 13: 1814-21. (Pubitemid 28535837)
60. Courteix D, Jaffre C, Lespessailles E, Benhamou L. Cumulative effects of calcium supplementation and physical activity on bone accretion in premenarchal children: a double-blind randomised placebo-controlled trial. Int J Sports Med 2005; 26: 332-8. (Pubitemid 40834699)
61. Fuchs RK, Bauer JJ, Snow CM. Jumping improves hip and lumbar spine bone mass in prepubescent children: a randomized controlled trial. J Bone Miner Res 2001; 16: 148-56. (Pubitemid 32046200)
62. Heinonen A, Sievanen H, Kannus P, Oja P, Pasanen M, Vuori I. High-impact exercise and bones of growing girls: a 9-month controlled trial. Osteoporos Int 2000; 11: 1010-7. (Pubitemid 32144592)
63. Iuliano-Burns S, Saxon L, Naughton G, Gibbons K, Bass SL. Regional specificity of exercise and calcium during skeletal growth in girls: a randomized controlled trial. J Bone Miner Res 2003; 18: 156-62. (Pubitemid 36008352)
64. Laing EM, Wilson AR, Modlesky CM, O'Connor PJ, Hall DB, Lewis RD. Initial years of recreational artistic gymnastics training improves lumbar spine bone mineral accrual in 4- to 8-year-old females. J Bone Miner Res 2005; 20: 509-19. (Pubitemid 40293500)
65. MacKelvie KJ, Khan KM, Petit MA, Janssen PA, McKay HA. A school-based exercise intervention elicits substantial bone health benefits: a 2-year randomized controlled trial in girls. Pediatrics 2003; 112(6 Pt : e1): 447.
66. Mackelvie KJ, McKay HA, Khan KM, Crocker PR. A school-based exercise intervention augments bone mineral accrual in early pubertal girls. J Pediatr 2001; 139: 501-8. (Pubitemid 32977263)
67. MacKelvie KJ, McKay HA, Petit MA, Moran O, Khan KM. Bone mineral response to a 7-month randomized controlled, school-based jumping intervention in 121 prepubertal boys: associations with ethnicity and body mass index. J Bone Miner Res 2002; 17: 834-44. (Pubitemid 34441900)
68. MacKelvie KJ, Petit MA, Khan KM, Beck TJ, McKay HA. Bone mass and structure are enhanced following a 2-year randomized controlled trial of exercise in prepubertal boys. Bone 2004; 34: 755-64. (Pubitemid 38393813)
69. McKay HA, MacLean L, Petit M, MacKelvie-O'Brien K, Janssen P, Beck T, et al. Bounce at the Bell': a novel program of short bouts of exercise improves proximal femur bone mass in early pubertal children. Br J Sports Med 2005; 39: 521-6. (Pubitemid 41081332)
70. McKay HA, Petit MA, Schutz RW, Prior JC, Barr SI, Khan KM. Augmented trochanteric bone mineral density after modified physical education classes: a randomized school-based exercise intervention study in prepubescent and early pubescent children [see comments]. J Pediatr 2000; 136: 156-62. (Pubitemid 30470984)
71. Morris FL, Naughton GA, Gibbs JL, Carlson JS, Wark JD. Prospective ten-month exercise intervention in premenarcheal girls: positive effects on bone and lean mass. J Bone Miner Res 1997; 12: 1453-62. (Pubitemid 27375389)
72. Nichols DL, Sanborn CF, Love AM. Resistance training and bone mineral density in adolescent females. J Pediatr 2001; 139: 494-500. (Pubitemid 32977262)
73. Petit MA, McKay HA, MacKelvie KJ, Heinonen A, Khan KM, Beck TJ. A randomized school-based jumping intervention confers site and maturity-specific benefits on bone structural properties in girls: a hip structural analysis study. J Bone Miner Res 2002; 17: 363-72. (Pubitemid 34171750)
74. Stear SJ, Prentice A, Jones SC, Cole TJ. Effect of a calcium and exercise intervention on the bone mineral status of 16-18-y-old adolescent girls. Am J Clin Nutr 2003; 77: 985-92.
75. Van Langendonck L, Claessens AL, Vlietinck R, Derom C, Beunen G. Influence of weight-bearing exercises on bone acquisition in prepubertal monozygotic female twins: a randomized controlled prospective study. Calcif Tissue Int 2003; 72: 666-74. (Pubitemid 36917320)
76. Witzke KA, Snow CM. Effects of plyometric jump training on bone mass in adolescent girls. Med Sci Sports Exerc 2000; 32: 1051-7. (Pubitemid 30390266)
77. Linden C, Ahlborg HG, Besjakov J, Gardsell P, Karlsson MK. A school curriculum-based exercise program increases bone mineral accrual and bone size in prepubertal girls: two-year data from the Pediatric Osteoporosis Prevention (POP) study. J Bone Miner Res 2006; 21: 829-35. (Pubitemid 43787989)
78. Alwis G, Linden C, Ahlborg H, Dencker M, Gardsell P, Karlsson M. A school-curriculum-based exercise program in pre-pubertal boys for two years induces skeletal benefits in lumbar spine - data from the Pediatric Osteoporosis Prevention (POP) study. Acta Paediatr 2008, Jul 30 [Epub ahead of print].
79. Linden C, Gärdsell P, Ahlborg H, Karlsson M. A school curriculum based exercise program increase bone mineral accrual in boys and girls during early adolescence - four year data from the POP study (Pediatric Preventive Osteoporotic study). J Bone Miner Res 2005; 20: 75.
80. Linden C, Gärdsell P, Johnell O, Karlsson M. A school curriculum based exercise program increase bone mineral accrual in boys and girls during early adolescence - three year data from the POP study (Pediatric Preventive Osteoporotic study) - a prospective controlled intervention study in 223 children. J Bone Miner Res 2004; 19(Supp1): S38.
81. Valdimarsson O, Linden C, Johnell O, Gardsell P, Karlsson MK. Daily physical education in the school curriculum in prepubertal girls during 1 year is followed by an increase in bone mineral accrual and bone width - data from the prospective controlled Malmo pediatric osteoporosis prevention study. Calcif Tissue Int 2006; 78: 65-71.
82. Linden C, Alwis G, Ahlborg H, Gardsell P, Valdimarsson O, Stenevi-Lundgren S, et al. Exercise, bone mass and bone size in prepubertal boys: one-year data from the pediatric osteoporosis prevention study. Scand J Med Sci Sports 2007; 17: 340-7.
83. Bass S, Saxon L, Iuliano-Burns S, Naughton G, Daly R, Nowson C, et al. Limitations of long term exercise interventions aimed at improving bone health in normally active boys. J Bone Miner Res 2003; 18(2 Suppl): M 151.
84. Ward KA, Roberts SA, Adams JE, Mughal MZ. Bone geometry and density in the skeleton of pre-pubertal gymnasts and school children. Bone 2005; 36: 1012-8. (Pubitemid 40798002)
85. Dyson K, Blimkie CJ, Davison KS, Webber CE, Adachi JD. Gymnastic training and bone density in pre-adolescent females. Med Sci Sports Exerc 1997; 29: 443-50. (Pubitemid 27183579)
86. Ducher G, Tournaire N, Meddahi-Pelle A, Benhamou CL, Courteix D. Short-term and long-term site-specific effects of tennis playing on trabecular and cortical bone at the distal radius. J Bone Miner Metab 2006; 24: 484-90. (Pubitemid 44663421)
87. Duncan CS, Blimkie CJ, Kemp A, Higgs W, Cowell CT, Woodhead H, et al. Mid-femur geometry and biomechanical properties in 15- to 18-yr-old female athletes. Med Sci Sports Exerc 2002; 34: 673-81. (Pubitemid 34408698)
88. Greene DA, Naughton GA, Briody JN, Kemp A, Woodhead H, Corrigan L. Bone strength index in adolescent girls: does physical activity make a difference? Br J Sports Med 2005; 39: 622-7; discussion 627.
89. Turner CH, Burr DB. Basic biomechanical measurements of bone: a tutorial. Bone 1993; 14: 595-608. (Pubitemid 23198821)
90. Haapasalo H, Kontulainen S, Sievanen H, Kannus P, Jarvinen M, Vuori I. Exercise-induced bone gain is due to enlargement in bone size without a change in volumetric bone density: a peripheral quantitative computed tomography study of the upper arms of male tennis players. Bone 2000; 27: 351-7. (Pubitemid 30658117)
91. Macdonald HM, Kontulainen SA, Khan KM, McKay HA. Is a school-based physical activity intervention effective for increasing tibial bone strength in boys and girls? J Bone Miner Res 2007; 22: 434-46. (Pubitemid 46797127)
92. Daly RM. The effect of exercise on bone mass and structural geometry during growth. In: Daly RM, Petit MA, eds. Optimizing bone mass and strength. The role of physical activity and nutrition during growth, vol. 51. Basel: Karger; 2007. p. 33-49.
93. Ruff CB, Walker A, Trinkaus E. Postcranial robusticity in Homo. III: Ontogeny. Am J Phys Anthropol 1994; 93: 35-54. (Pubitemid 24020097)
94. Brahm H, Mallmin H, Michaelsson K, Strom H, Ljunghall S. Relationships between bone mass measurements and lifetime physical activity in a Swedish population. Calcif Tissue Int 1998; 62: 400-12. (Pubitemid 28180836)
95. Magnusson HI, Westlin NE, Nyqvist F, Gardsell P, Seeman E, Karlsson MK. Abnormally decreased regional bone density in athletes with medial tibial stress syndrome. Am J Sports Med 2001; 29: 712-5. (Pubitemid 33078905)
96. Pearce G, Bass S, Young N, Formica C, Seeman E. Does weight-bearing exercise protect against the effects of exercise-induced oligomenorrhea on bone density? Osteoporos Int 1996; 6: 448-52. (Pubitemid 27007698)
97. Micklesfield LK, Reyneke L, Fataar A, Myburgh KH. Long-term restoration of deficits in bone mineral density is inadequate in premenopausal women with prior menstrual irregularity. Clin J Sport Med 1998; 8: 155-63. (Pubitemid 28457120)
98. Malm HT, Ronni-Sivula HM, Viinikka LU, Ylikorkala OR. Marathon running accompanied by transient decreases in urinary calcium and serum osteocalcin levels. Calcif Tissue Int 1993; 52: 209-11. (Pubitemid 23090713)
99. Garn S. The earlier gain and later loss of cortical bone. Nutritional perspectives. Springfield, IL: Charles C. Thomas; 1970. p. 3-120.
100. Alexy U, Remer T, Manz F, Neu CM, Schoenau E. Long-term protein intake and dietary potential renal acid load are associated with bone modeling and remodeling at the proximal radius in healthy children. Am J Clin Nutr 2005; 82: 1107-14. (Pubitemid 43779772)
101. Bass SL, Naughton G, Saxon L, Iuliano-Burns S, Daly R, Briganti EM, et al. Exercise and calcium combined results in a greater osteogenic effect than either factor alone: a blinded randomized placebo-controlled trial in boys. J Bone Miner Res 2007; 22: 458-64. (Pubitemid 46797129)
102. Jackman LA, Millane SS, Martin BR, Wood OB, McCabe GP, Peacock M, et al. Calcium retention in relation to calcium intake and postmenarcheal age in adolescent females. Am J Clin Nutr 1997; 66: 327-33. (Pubitemid 27360331)
103. Specker BL. Evidence for an interaction between calcium intake and physical activity on changes in bone mineral density. J Bone Miner Res 1996; 11: 1539-44. (Pubitemid 26331010)
104. Binkley N, Krueger D, Cowgill CS, Plum L, Lake E, Hansen KE, et al. Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization. J Clin Endocrinol Metab 2004; 89: 3152-7. (Pubitemid 38951877)
105. Johannsen N, Binkley T, Englert V, Neiderauer G, Specker B. Bone response to jumping is site-specific in children: a randomized trial. Bone 2003; 33: 533-9. (Pubitemid 37222379)