A new method to study sensory modulation of locomotor networks by activation of thermosensitive cutaneous afferents using a hindlimb attached spinal cord preparation

Journal of Neuroscience Methods

Volumn 182, Issue 2, 2009, Pages 255-259

  Mandadi, Sravan ^a   Whelan, Patrick J ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Afferents; CPG; Mouse; Nociceptors; Sensory; Spinal cord; TRP

Indexed keywords

ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HINDLIMB; IN VITRO STUDY; LOCOMOTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSORY NERVE; SENSORY RECEPTOR; SENSORY SYSTEM; SPINAL CORD; TEMPERATURE;

ANIMALS; CAPSAICIN; CAUDA EQUINA; COLD TEMPERATURE; DOPAMINE; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID AGONISTS; HINDLIMB; HOT TEMPERATURE; LOCOMOTION; MICE; N-METHYLASPARTATE; NERVE NET; NEURONS, AFFERENT; SENSATION; SEROTONIN; SKIN; SPINAL CORD; STIMULATION, CHEMICAL; THERMORECEPTORS; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPV CATION CHANNELS;

EID: 68249119257     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2009.06.011     Document Type: Article

References (13)

1. Bautista D.M., Siemens J., Glazer J.M., Tsuruda P.R., Basbaum A.I., Stucky C.L., et al. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 448 (2007) 204-208
2. Blivis D., Mentis G.Z., O'Donovan M.J., and Lev-Tov A. Differential effects of opioids on sacrocaudal afferent pathways and central pattern generators in the neonatal rat spinal cord. J Neurophysiol 97 (2007) 2875-2886
3. Caterina M.J., Schumacher M.A., Tominaga M., Rosen T.A., Levine J.D., and Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389 (1997) 816-824
4. Cowley K.C., and Schmidt B.J. Some limitations of ventral root recordings for monitoring locomotion in the in vitro neonatal rat spinal cord preparation. Neurosci Lett 171 (1994) 142-146
5. Jiang Z., Carlin K.P., and Brownstone R.M. An in vitro functionally mature mouse spinal cord preparation for the study of spinal motor networks. Brain Res 816 (1999) 493-499
6. Lumpkin E.A., and Caterina M.J. Mechanisms of sensory transduction in the skin. Nature 445 (2007) 858-865
7. Madriaga M.A., McPhee L.C., Chersa T., Christie K.J., and Whelan P.J. Modulation of locomotor activity by multiple 5-HT and dopaminergic receptor subtypes in the neonatal mouse spinal cord. J Neurophysiol 92 (2004) 1566-1576
8. Mandadi S, Nakanishi ST, Takashima Y, Dhaka A, Patapoutian A, McKemy DD, Whelan PJ. Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels. Neuroscience 2009 doi:10.1016/j.neuroscience.2009.05.063 (in Press).
9. Mandadi S., and Roufogalis B.D. ThermoTRP channels in nociceptors: taking a lead from capsaicin receptor TRPV1. Curr Neuropharmacol 6 (2008) 21-38
10. McKemy D.D., Neuhausser W.M., and Julius D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416 (2002) 52-58
11. Pearson K.G. Generating the walking gait: role of sensory feedback. Prog Brain Res 143 (2004) 123-129
12. Pearson S.A., Mouihate A., Pittman Q.J., and Whelan P.J. Peptidergic activation of locomotor pattern generators in the neonatal spinal cord. J Neurosci 23 (2003) 10154-10163
13. Whelan P., Bonnot A., and O'Donovan M.J. Properties of rhythmic activity generated by the isolated spinal cord of the neonatal mouse. J Neurophysiol 84 (2000) 2821-2833