Trilostane exerts antidepressive effects among wild-type, but not estrogen receptor β knockout mice

NeuroReport

Volumn 20, Issue 12, 2009, Pages 1047-1050

  Koonce, Carolyn J ^a   Walf, Alicia A ^a   Frye, Cheryl A ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

3 hydroxy 5 pregnan 20 one; Breast cancer; Depression; Estrogen; Tamoxifen

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR BETA; TRILOSTANE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CONTROLLED STUDY; DOSE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

ANALYSIS OF VARIANCE; ANIMALS; ANTIDEPRESSIVE AGENTS; CORTICOSTERONE; DEPRESSION; DIHYDROTESTOSTERONE; ESTROGEN RECEPTOR BETA; HIPPOCAMPUS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; NEUROPSYCHOLOGICAL TESTS; PREGNANOLONE; RADIOIMMUNOASSAY; SWIMMING; TIME FACTORS;

EID: 68249097509     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e32832e0c44     Document Type: Article

References (25)

1. Puddefoot JR, Barker S, Vinson GP. Trilostane in advance breast cancer. Expert Opin Pharmacother 2006; 7:2413-2419.
2. Puddefoot JR, Barker S, Glover HR, Malouitre SD, Vinson GP. Non-competitve inhibition of oestrogen receptor functions. Int J Cancer 2002; 101:17-22. (Pubitemid 34832992)
3. Murphy LC, Peng B, Lewis A, Davie JR, Leygue E, Kemp A, et al. Inducible up regulation of oestrogen receptor-beta 1 affects oestrogen and tamoxifen responsiveness in MCF-7 human breast cancer cells. J Mol Endocrinol 2005; 33:553-566. (Pubitemid 40585201)
4. Bruer B, Anderson R. The relationship of tamoxifen with dementia, depression, and dependence in activies of daily living elderly nursing home residents. Women Health 2000; 31:71-85. (Pubitemid 30779901)
5. Shariff S, Cumming CE, Lees A, Handman M, Cumming DC. Mood disorder in women with early breast cancer taking tamoxifen, an estradiol receptor antagonist. An expected or unexpected effect? Ann N Y Acad Sci 1995; 761:365-368.
6. Shughrue PJ, Lane MV, Scrimo PJ, Merchenthaler I. Comparative distribution of estrogen receptor-alpha (ER-alpha) and beta (ER-beta) mRNA in the rat pituitary, gonad, and reproductive tract. Steroids 1998; 63:498-504. (Pubitemid 28475879)
7. Walf AA, Frye CA. Rapid and estrogen receptor beta mediated actions in the hippocampus mediate some functional effects of estrogen. Steroids 2008; 73:997-1007.
8. Walf AA, Koonce CJ, Frye CA. Adult female wildtype, but not oestrogen receptor {beta} knockout, mice have decreased depression-like behaviour during pro-oestrus and following administration of oestradiol or diarylpropionitrile. J Psychopharmacol 2008; 23:442-450.
9. Walf AA, Koonce C, Manley K, Frye CA. Proestrous compared to diestrous wildtype, but not estrogen receptor beta knockout, mice have better performance in the spontaneous alternation and object recognition tasks and reduced anxiety-like behavior in the elevated plus and mirror maze. Behav Brain Res 2008; 196:254-260.
10. Espallergues J, Givalois L, Laruelle C, Maurice T. Antidepressant potential of 3beta-hydroxysteriod dehydrogenase inhibitor trilostane in mice. Society for Neuroscience Abstract. 2007. online.
11. Frye CA, Walf AA, Rhodes ME, Harney JP. Progesterone enhances motor, anxiolytic, analgesic, and antidepressive behavior of wild-type mice, but not those deficient in type 1 5α-reductase. Brain Res 2004; 1004:116-124
12. Robel J, Young C, Corpechot W, Mayo F, Perche M, Haug H, et al. Biosynthesis and assay of neurosteriods in rats and mice: functional correlates. J Steroid Biochem Mol Biol 1995; 53:355-360.
13. Rupprect R. Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties. Psychoneuroendocrinology 2003; 28:139-168
14. Frye CA, Walf AA. Hippocampal 3alpha, 5alpha-THP may alter depressive behavior of pregnant and lactating rats. Pharmacol Biochem Behav 2004; 78:531-540.
15. Frye CA, Sumida K, Dudek BC, Harney JP, Lydon JP, O'Malley BW, et al. Progesterone's effects to reduce anxiety behavior of aged mice do not require actions via intracellular progestin receptors. Psychopharmacology 2006; 86:312-322. (Pubitemid 43800833)
16. Frye CA, Walf AA. Changes in progesterone metabolites in the hippocampus can modulate open field and forced swim test behavior of proestrous rats. Horm Behav 2002; 41:306-315.
17. Rocha BA, Fleischer R, Schaeffer JM, Rohrer SP, Hickey GJ. 17β-estradiol-induced antidepressant-like effect in the forced swim test is absent in estrogen receptor-b knockout (βERKO) mice. Psychopharmacology 2005; 179:637-643. (Pubitemid 40674765)
18. Freeman EW, Frye CA, Rickels K, Martin PA, Smith SS. Allopregnanolone levels and symptom improvement in severe premenstrual syndrome. J Clin Psychopharmacol 2002; 22:516-520.
19. Romeo E, Ströhle A, Spalletta G, di Michele F, Hermann B, Holsboer F, et al. Effects of antidepressant treatment on neuroactive steroids in major depression. Am J Psychiatry 1998; 155:910-913. (Pubitemid 28307602)
20. Uzunova V, Sheline Y, Davis JM, Rasmusson A, Uzunov DP, Costa E, Guidotti A. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proc Natl Acad Sci U S A 1998; 95:3239-3244. (Pubitemid 28135886)
21. Frye CA, Wawrzycki J. Effect of prenatal stress and gonodal hormone condition on depressive behaviors of female and male rats. Horm Behav 2003; 44:319-326. (Pubitemid 37378211)
22. Stahl SM. Sex therapy in psychiatric treatment has a new partner: reproductive hormones. J Clin Psychiatry 1997; 58:468-469.
23. Young E, Carlson NE, Brown MB. Twenty-four-hour ACTH and cortisol pulsatility in depressed women. Neuropsychopharmacology 2001; 25:267-276.
24. Walf AA, Frye CA. ERbeta-selective estrogen receptor modulators produce antianxiety behavior when administered systemically to ovariectomized rats. Neuropsychopharmacology 2005; 30:1598-1609.
25. Iino Y, Izuo M, Takikawa H. Effects of trilostane on 7,12-dimethylbenz[a] anthracene-induced rat mammary cancers and body weight of rats in relation to estrogen receptors. Oncology 1989; 46:301-315. (Pubitemid 19216750)