Preliminary in vitro investigation of the potential health effects of optisol, a nanoparticulate manganese modified titanium dioxide UV-filter used in certain sunscreen products

Nanotoxicology

Volumn 3, Issue 2, 2009, Pages 73-90

  Park, Barry ^a   Martin, Patricia A ^b   Harris, Chris ^a   Guest, Robert ^c   Whittingham, Andrew ^c   Jenkinson, Peter ^c  

^a Oxonica   (United Kingdom)

^b Product Assessment and Regulatory Compliance   (United Kingdom)

^c Safepharm Laboratories Ltd   (United Kingdom)

Author keywords

In vitro toxicology; Nanoparticles; Sunscreen; Titanium dioxide

Indexed keywords

MANGANESE; NANOPARTICLE; SUNSCREEN; TITANIUM DIOXIDE;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; EVALUATION; EYE IRRITATION; GENOTOXICITY; HEALTH HAZARD; HUMAN; HUMAN CELL; PHOTOTOXICITY; PRIORITY JOURNAL; SCREENING; SKIN IRRITATION; TOXICITY TESTING; ULTRAVIOLET RADIATION;

EID: 68249088486     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.1080/17435390802691786     Document Type: Article

References (59)

1. American Conference of Governmental Industrial Hygienists. 2000. 2000 TLVs and BEIs. Based on the documentations of the threshold limit values and biological exposure indices. Cincinnati, OH: ACGIH.
2. Boffetta P, Soutar A, Cherrie JW, Granath F, Andersen A, Anttila A, Blettner M, Gaborieau V, Klug SJ, Langard S, Luce D, Merletti F, Miller B, Mirabelli D, Pukkala E, Adami H-O, Weiderpass E. 2004. Mortality among workers employed in the titanium dioxide production industry in Europe. Cancer Causes Control 15:697-706.
3. Boots (UK) Ltd. 2008. Measurement of UVa:UVb ratios according to the Boots Star rating System (2008 Revision). Nottingham UK: Boots (UK) Ltd.
4. Briggs D, Seah MP, editors. 1990. Practical surface analysis. Vol. 1, 2nd ed. New York: Wiley.
5. BS EN ISO 10993-5. 1999. Biological evaluation of medical devices. Tests for in vitro cytotoxicity.
6. Cancer Research UK. 2008. UK Skin cancer incidence statistics. Accessed from the website: http://info.cancerresearchuk.org/ cancerstats/types/skin/ incidence.
7. Cerutti PA. 1985. Prooxidant states and tumour promotion. Science 227:375-381.
8. Cerutti PA. 1994. Oxy-radicals and cancer. Lancet 344:862-863.
9. Colvin V. 2003. Point of impact: Where technology collides with society, business, and personal lives. Technol Rev 106:71-73.
10. De Silva O, Rougier A, Dossou KG. 1992. The HET-CAM test: A study of the irritation potential of chemicals and formulations. ATLA 20:432-437.
11. Diffey BL, Robson J. 1989. A new substrate to measure sunscreen protection factors throughout the ultraviolet spectrum. J Soc Cosmet Chem 40:127-133.
12. Donaldson K, Tran C. 2002. Inflammation caused by particles and fibres. Inhal Toxicol 14:5-27.
13. Donawho CK, Wolf P. 1996. Sunburn. sunscreen and melanoma Curr Opin Oncol 8:159.
14. EEC Council Directive. 1976. 76/768/EEC of the 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products. Official Journal L262 27/9/1976. pp 169-200.
15. Fallerl C, Barcher M, Dami N, Roguet R. 2002. Predictive ability of reconstructed human epidermis equivalents for the assessment of skin irritation of cosmetics. Toxicol in Vitro 16: 557-572.
16. Fryzek JP, Chadda B, Marano D, White K, Schweitzer S, McLaughlin JK, Blot WJ. 2003. A cohort mortality study among titanium dioxide manufacturing workers in the United States. J Occup Environ Med 45:400-409.
17. Greiter F. 1974. Sun protection factor - origin and methods. Sonderdr Parfum Kosmet 55:70-75.
18. Greiter F. 1981. What is light protection? Sun protection factor and problems in determining it. Apotheker J 4/5:58-61.
19. Gulleron L, Coecke S, Sysmans M, Hansen E, van Oproy S, Marzin D, van Cauteren H, Vanparys Ph. 1997. Evaluation of the HET-CAM-TSA method as an alternative to the Draize eye irritation test. Toxicol in vitro 11(5):641-644.
20. Hartung T 2007. Statement on the validity of in vitro tests for skin irritation. ECVAM 27 April.
21. Hecht E, Zajac A. 1987. Optics. 2nd ed. Addison Wesley. Reading, Mass.
22. Heinrich U, Fuhst R, Rittinghausen S, Creutzenberg O, Bellman B, Koch W, Levsen K. 1995. Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel-engine exhaust, carbon black and titanium dioxide. Inhal Tox 7(4):533-556.
23. Institute for Environment and Health. 1999. IEH report on approaches to predicting toxicity from occupational exposure to dusts. An appraisal of low toxicity dusts. Report R11. MRC
24. International Agency for Research on Cancer (IARC). 1989. Monographs on the evaluation of carcinogenic risks to humans: Some organic solvents, resin monomers and related compounds, pigments and occupational exposures in paint manufacture and painting. Vol. 47. Lyon, France: IARC.
25. International Agency for Research on Cancer (IARC). 2006. Monographs on the evaluation of carcinogenic risks to humans: Carbon black, titanium dioxide and non-asbestiform talc. Vol. 93. In Preparation. Meeting Feb.
26. International Agency for Research on Cancer. 2001. IARC Handbooks of Cancer Prevention. Sunscreens. Vol. 5.
27. ISD Online. 2007. Cancer mortality in Scotland; 2006.
28. IUCLID CD-ROM. 2000. Public data on high volume chemicals. European Commission Joint Research Centre, European Chemicals Bureau. EUR 19559 EN.
29. Kirkland DJ, editor. 1989. Statistical evaluation of mutagenicity test data UKEMS sub-committee on guidelines for mutagenicity testing. Report Part III. Cambridge University Press.
30. La Vecchia C, Lucchini F, Negri E, Levi F, La Vecchia C, et al. 1999. Recent declines in worldwide mortality from cutaneous melanoma in youth and middle age. Int J Cancer 81(1):62-66.
31. 2) by inhalation for two years. Toxicol Appl Pharmacol 79:179-192.
32. Luepke NP 1985. Hen's egg chorionallantoic membrane test for irritation potential. Food Chem Toxicol 23(2):287-291.
33. Maron DM, Ames BN. 1983. Revised methods for the Salmonella mutagenicity test. Mutat Res 113:173-215.
34. Miller DL, Weinstock MA. 1994. Nonmelanoma skin cancer in the United States: Incidence. J Am Acad Dermatol 30: 774-778.
35. Mitchell DL. 2003. DNA damage and repair. In: Horspool W, Lenci F, editors. A handbook of organic photochemistry and photobiology. 2nd ed. London: CRC Press.
36. Muhle H, Bellman B, Creutzenberg O, Dasenbrock C, Ernst H, Kilpper R, Mackenzie JC, Morrow P, Mohr U, Takenaka S, Mermelstein R. 1991. Pulmonary response to toner upon chronic inhalation exposure in rats. Fund Appl Toxicol 17:280-299.
37. NANODERM. 2007. Quality of skin as a barrier to ultra-fine particles. QLK4-CT-2002-02678. Final Report.
38. Northern Ireland Cancer Registry. 2008. Cancer mortality in Northern Ireland; 2005.
39. Oberdörster G, Oberdörster E, Oberdörster J. 2005. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113(7):823-839.
40. Oberdörster G. 1994. Extrapolation of results from animal inhalation studies with particles to humans. In: Dungworth, Mohr, Mauderly, Oberdörster, editors. Toxic and carcinogenic effects of solid particles in the respiratory tract. ILSI Press. Washington DC, USA.
41. Oberdörster G. 1995. Lung particle overload: Implications for occupational exposures to particles. Regul Toxicol Pharmacol 21:123-135.
42. Office for National Statistics. 2006. Mortality statistics: Cause, England and Wales 2006. London TSO 2007.
43. Organisation for Economic Co-operation and Development (OECD). 1997. Test Guideline 471 Bacterial Reverse mutation test. Adopted 21 July, 1997.
44. Organisation for Economic Co-operation and Development (OECD). 2004. Test Guideline 432 In vitro 3T3 NRU Photoxicity test. Adopted 13 April 2004.
45. Organisation for Economic Co-operation and Development (OECD). 2002. Test Guideline 404 Acute dermal irritation/ corrosion. Adopted 24 April 2002.
46. Rampaul A, Parkin IP, Cramer LP. 2007. Damaging and protecting properties of inorganic components of sunscreens applied to cultured human skin cells. J Photochem Photobiol 191:138-148.
47. Sayes CM, Wahi R, Kurian PA, Liu Y, West JL, Ausman KD, Warheit DB, Colvin VL. 2006. Correlating nanoscale titania structure with toxicity: A cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells. Toxicol Sci 92(1):174-185.
48. Scharffetter-Kochanek K, Wlaschek M, Brenneisen P, Schauen M, Blaudschun R, Wenk J. 1997. UV-induced reactive oxygen species in photocarcinogenesis and photoaging. Biol Chem 378:1247-1257.
49. Schulze R. 1956a. Some tests and remarks regarding the problem of sunscreens that are found on the market. Parfum Kosmet 37:310-316.
50. Schulze R. 1956b. Some tests and remarks regarding the problem of sunscreens that are found on the market. Parfum Kosmet 37:365-372.
51. Severi G, Giles GG, Robertson C, Boyle CP, Autier P. 2000. Mortality from cutaneous melanoma: Evidence for contrasting trends between populations. Br J Cancer 82(11):1887-1891.
52. Shirley DA. 1972. High-resolution X-Ray photoemission spectrum of the valence bands of gold. Phys Rev B 5:4709.
53. UK Health & Safety Executive. 1998. Occupational exposure limits 1998 (EH40/98). Sudbury, UK: HSE Books.
54. US National Institute for Occupational Safety & Health (NIOSH). 2005. Current Intelligence Bulletin: Evaluation of health hazard and recommendations for Occupational Exposure to titanium dioxide. Draft Nov. 2005.
55. Wakefield G, Green M, Lipscomb S, Flutter B. 2004a. Modified titania nanomaterials for sunscreen applications - reducing free radical generation and DNA damage. Materials Sci Technol 20(8):985-988.
56. Wakefield G, Lipscomb S, Holland E, Knowland J. 2004b. The effects of manganese doping on UVA absorption and free radical generation of micronised titanium dioxide and its consequences for the photostability of UVA absorbing organic sunscreen components. Photochem Photobiol Sci 3:648-652.
57. Wakefield G, Stott J, Hock J. 2005. Sunscreens and cosmetics containing manganese doped titanium dioxide nanoparticles. SOFW-J 131:46-51.
58. Wakefield G, Stott J. 2006. Photostabilisation of organic UV-absorbing and anti-oxidant cosmetic components in formulations containing micronised manganese-doped titanium dioxide. J Cosmet Sci 57:385-395.
59. World Health Organization (WHO). 2000. Accessed from the internet website: www.who.int/mediacentre/factsheets