Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 29, Issue 8, 2009, Pages 1475-1481

  Zhang, Wenri ^a   Iliff, Jeffrey J ^a   Campbell, Caitlyn J ^a   Wang, Ruikang K ^b   Hurn, Patricia D ^a   Alkayed, Nabil J ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b Oregon Health and Science University Department of Biomedical Engineering   (United States)

Author keywords

EETs; Epoxide hydrolase; Estrogen; Ischemia; Optical imaging

Indexed keywords

EPOXIDE HYDROLASE; EPOXYICOSATRIENOIC ACID; ESTRADIOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; BRAIN DAMAGE; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PERFUSION; CONTROLLED STUDY; FEMALE; MALE; MICROANGIOGRAPHY; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

8,11,14-EICOSATRIENOIC ACID; ANIMALS; BLOOD FLOW VELOCITY; BLOTTING, WESTERN; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPOXIDE HYDROLASES; ESTROGENS; FEMALE; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MICE; MICE, KNOCKOUT; OVARIECTOMY; SEX CHARACTERISTICS; SOLUBILITY;

EID: 68249087936     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2009.65     Document Type: Article

References (19)

1. Alkayed NJ, Harukuni I, Kimes AS, London ED, Traystman RJ, Hurn PD (1998) Gender-linked brain injury in experimental stroke. Stroke 29:159-65
2. Fleming I (2007) Epoxyeicosatrienoic acids, cell signaling and angiogenesis. Prostaglandins Other Lipid Mediat 82:60-7
3. Kiss L, Roder Y, Bier J, Weissmann N, Seeger W, Grimminger F (2008) Direct eicosanoid profiling of the hypoxic lung by comprehensive analysis via capillary liquid chromatography with dual online photodiode-array and tandem mass-spectrometric detection. Anal Bioanal Chem 390:697-714
4. Koerner IP, Zhang W, Cheng J, Parker S, Hurn PD, Alkayed NJ (2008) Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia. Front Biosci 13:2833-41
5. Liu M, Hurn PD, Alkayed NJ (2004) Cytochrome P450 in neurological disease. Curr Drug Metab 5:225-34
6. Miller VM, Duckles SP (2008) Vascular actions of estrogens: functional implications. Pharmacol Rev 60:210-41
7. Munzenmaier DH, Harder DR (2000) Cerebral microvascular endothelial cell tube formation: role of astrocytic epoxyeicosatrienoic acid release. Am J Physiol Heart Circ Physiol 278:H1163-7
8. Nithipatikom K, DiCamelli RF, Kohler S, Gumina RJ, Falck JR, Campbell WB, Gross GJ (2001) Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs. Anal Biochem 292:115-24
9. Pinot F, Grant DF, Spearow JL, Parker AG, Hammock BD (1995) Differential regulation of soluble epoxide hydrolase by clofibrate and sexual hormones in the liver and kidneys of mice. Biochem Pharmacol 50:501-8
10. Reeves MJ, Bushnell CD, Howard G, Gargano JW, Duncan PW, Lynch G, Khatiwoda A, Lisabeth L (2008) Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes. Lancet Neurol 7: 915-26
11. Sinal CJ, Miyata M, Tohkin M, Nagata K, Bend JR, Gonzalez FJ (2000) Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation. J Biol Chem 275:40504-10
12. Spector AA, Norris AW (2007) Action of epoxyeicosatrienoic acids on cellular function. Am J Physiol Cell Physiol 292:C996-1012
13. Suzuki S, Oguro A, Osada-Oka M, Funae Y, Imaoka S (2008) Epoxyeicosatrienoic acids and/or their metabolites promote hypoxic response of cells. J Pharmacol Sci 108:79-88
14. Wang RK (2007) Three-dimensional optical micro-angiography maps directional blood perfusion deep within microcirculation tissue beds in vivo. Phys Med Biol 52:N531-7
15. Wang RK, Hurst S (2007) Mapping of cerebrovascular blood perfusion in mice with skin and cranium intact by Optical Micro-Angio Graphy at 1300 nm wavelength. Opt Express 15:11402-12
16. Wang RK, Jacques SL, Ma Z, Hurst S, Hanson S, Gruber A (2007) Three dimensional optical angiography. Opt Express 15:4083-97
17. Webler AC, Michaelis R, Popp R, Barbosa-Sicard E, Murugan A, Falck JR, Fisslthaler B, Fleming I (2008) Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis. Am J Physiol Cell Physiol 295:C1292-301
18. Zhang W, Koerner IP, Noppens R, Grafe M, Tsai HJ, Morisseau C, Luria A, Hammock BD, Falck JR, Alkayed NJ (2007) Soluble epoxide hydrolase: a novel therapeutic target in stroke. J Cereb Blood Flow Metab 27:1931-40
19. Zhang W, Otsuka T, Sugo N, Ardeshiri A, Alhadid YK, Iliff JJ, DeBarber AE, Koop DR, Alkayed NJ (2008) Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia. Stroke 39:2073-8