Computer-aided detection of pulmonary embolism in computed tomographic pulmonary angiography (CTPA): Performance evaluation with independent data sets

Medical Physics

Volumn 36, Issue 8, 2009, Pages 3385-3396

  Zhou, Chuan ^a   Chan, Heang Ping ^a   Sahiner, Berkman ^a   Hadjiiski, Lubomir M ^a   Chughtai, Aamer ^a   Patel, Smita ^a   Wei, Jun ^a   Cascade, Philip N ^a   Kazerooni, Ella A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Computer aided detection; False positive reduction; Multiscale filtering; Pulmonary arteries; Pulmonary embolism; Vessel segmentation

Indexed keywords

ANGIOGRAPHY; COMPUTERIZED TOMOGRAPHY; DISCRIMINANT ANALYSIS; DISEASES; EIGENVALUES AND EIGENFUNCTIONS; MAXIMUM PRINCIPLE;

COMPUTER AIDED DETECTION; FALSE-POSITIVE REDUCTION; MULTI-SCALE FILTERING; PULMONARY ARTERY; PULMONARY EMBOLISM; VESSEL SEGMENTATION;

COMPUTER AIDED DIAGNOSIS;

ARTICLE; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; COMPUTER ASSISTED DIAGNOSIS; DISCRIMINANT ANALYSIS; HUMAN; LUNG ANGIOGRAPHY; LUNG EMBOLISM; MAJOR CLINICAL STUDY; PLEURA DISEASE; PREDICTOR VARIABLE; PRIORITY JOURNAL; PULMONARY ARTERY OCCLUSION; RADIOLOGIST;

EID: 68149179717     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.3157102     Document Type: Article

References (60)

1. J. Dalen and J. Alpert, " Natural history of pulmonary embolism.," Prog. Cardiovasc. Dis. 17, 257270 (1975).
2. D. Price, " Thoughts on immediate carePulmonary embolism. Prophylax diagnosis and treatment.," Anaesthesia 31, 925932 (1976). 10.1111/j.1365-2044.1976.tb11905.x
3. S. Rathbun, G. Raskob, and T. Whitsett, " Sensitivity and specificity of helical computed tomography in the diagnosis of pulmonary embolism: A systematic review.," Ann. Intern Med. 132, 227232 (2000).
4. J. Cross, P. Kemp, C. Walsh, C. Flower, and A. Dixon, " A randomized trial of spiral CT and ventilation perfusion scintigraphy for the diagnosis of pulmonary embolism.," Clin. Radiol. 53, 177182 (1998). 10.1016/S0009- 9260(98)80097-4 (Pubitemid 28118769)
5. K. Garg, C. Welsh, and A. Feyerabend, " Pulmonary embolism: Diagnosis with spiral CT and ventilation-perfusion scanning-correlation with pulmonary angiographic results or clinical outcome.," Radiology 208, 201208 (1998).
6. A. v. Rossum, P. Pattynama, W. Mallens, and J. Herman, " Can helical CT replace scintigraphy in the diagnostic process in suspected pulmonary embolism? A retrolective-prolective cohort study focusing on total diagnostic yield.," Eur. Radiol. 8, 9096 (1998). 10.1007/s003300050345
7. E. Drucker, S. Rivitz, and J. Shepard, " Acute pulmonary embolism: assessment of helical CT for diagnosis.," Radiology 209, 235241 (1998).
8. G. Ferretti, J. Bosson, and P. Buffaz, " Acute pulmonary embolism: role of helical CT in 164 patients with intermediate probability at ventilation-perfusion scintigraphy and normal results at duplex US of the legs.," Radiology 205, 453458 (1997).
9. J. Mayo, M. Remy-Jardin, and N. Muller, " Pulmonary embolism: Prospective comparison of spiral CT with ventilation perfusion scintigraphy.," Radiology 205, 447452 (1997).
10. T. Russi, D. Libby, and C. Henschke, " Clinical utility of computed tomography in the diagnosis of pulmonary embolism.," Clin. Imaging 21, 175182 (1997). 10.1016/S0899-7071(96)00014-9 (Pubitemid 27231994)
11. A. v. Rossum, P. Pattynama, and E. Ton, " Pulmonary embolism: Validation of spiral CT angiography in 149 patients.," Radiology 201, 467470 (1996).
12. M. Remy-Jardin, J. Remy, C. O. L. Petyt, J. Wannebroucq, and J. Beregi, " Diagnosis of central pulmonary embolism with helical CT: Role of two-dimensional multiplanar reformations.," AJR, Am. J. Roentgenol. 165, 11311138 (1995).
13. H. Blachere, V. Latrabe, and M. Montaudon, " Pulmonary embolism revealed on helical CT angiography: Comparison with ventilation-perfusion radionuclide lung scanning.," AJR, Am. J. Roentgenol. 174, 10411047 (2000).
14. M. Remy-Jardin and J. Remy, " Spiral CT angiography of the pulmonary circulation.," Radiology 212, 615636 (1999).
15. L. Goodman, J. Curtin, and M. Mewissen, " Detection of pulmonary embolism in patients with unsolved clinical and scintigraphic diagnosis: Helical CT versus angiography.," AJR, Am. J. Roentgenol. 164, 13691374 (1995).
16. L. Goodman, " CT diagnosis of pulmonary embolism and deep venous thrombosis.," Radiographics 20, 12011205 (2000).
17. S. D. Qanadli, M. E. Hajjam, B. Mesurolle, O. Barr, F. Bruckert, T. Joseph, F. Mignon, A. Vieillard-Baron, O. Dubourg, and P. Lacombe, " Pulmonary embolism detection: Prospective evaluation of dual-section helical CT versus selective pulmonary arteriography in 157 patients.," Radiology 217, 447455 (2000).
18. P. D. Stein, " Multidetector computed tomography for acute pulmonary embolism.," N. Engl. J. Med. 354, 23172327 (2006). 10.1056/NEJMoa052367 (Pubitemid 43801277)
19. L. R. Goodman, " Small pulmonary emboli: What do we know?," Radiology 234, 654658 (2005). 10.1148/radiol.2343041326 (Pubitemid 40250805)
20. M. Remy-Jardin, J. Remy, L. Wattinne, and F. Giraud, " Central pulmonary thromboembolism: diagnosis with spiral volumetric CT with the single-breath-hold technique-comparison with pulmonary angiography.," Radiology 185, 381387 (1992).
21. D. Diffin, J. Leyendecker, S. Johnson, R. Zucker, and P. Grebe, " Effect of anatomic distribution of pulmonary emboli on interobserver agreement in the interpretation of pulmonary angiography.," AJR, Am. J. Roentgenol. 171, 10851089 (1998).
22. G. Le Gal, R. Righini, F. Parent, M. V. Strijen, and F. Couturaud, " Diagnosis and management of subsegmental pulmonary embolism.," Thromb. Haemostasis 4, 724731 (2005). 10.1111/j.1538-7836.2006.01819.x
23. A. S. Wu, J. A. Pezzullo, H. J. Cronan, D. D. Hou, and W. W. Mayo-Smith, " CT pulmonary angiography: Quantification of pulmonary embolus as a predictor of patient outcome-initial experience.," Radiology 230, 831835 (2004). 10.1148/radiol.2303030083 (Pubitemid 38252884)
24. A. Bankier, " Severity assessment of acute pulmonary embolism with spiral CT: Evaluation of two modified angiographic scores and comparison with clinical data.," J. Thorac. Imaging 12, 150158 (1997).
25. S. D. Qanadli, M. E. Hajjam, A. Vieillard-Baron, T. Joseph, B. Mesurolle, O. Barr, F. Bruckert, O. Dubourg, and P. Lacombe, " New CT index to quantify arterial obstruction in pulmonary embolism: Comparison with angiographic index and echocardiography.," AJR, Am. J. Roentgenol. 176, 14151420 (2001).
26. I. Mastora, " Severity of acute pulmonary embolism: Evaluation of a new spiral CT angiographic score in correlation with echocardiographic data.," Eur. Radiol. 13, 2935 (2003).
27. K. Wood, L. Visani, and M. De Rosa, " Major pulmonary embolism: Review of a pathophysiologic approach to the golden hour of hemodynamically signification pulmonary embolism.," Chest 121, 877905 (2002). 10.1378/chest.121.3.877 (Pubitemid 34251458)
28. P. A. Araoz, " Helical CT pulmonary angiography predictors of in-hospital morbidity and mortality in patients with acute pulmonary embolism.," J. Thorac. Imaging 18, 207216 (2003). 10.1097/00005382- 200310000-00001 (Pubitemid 37310723)
29. U. J. Schoepf, N. Holzknecht, T. K. Helmberger, A. Crispin, C. Hong, C. R. Becker, and M. F. Reiser, " Subsegmental pulmonary emboli: Improved detection with thin-collimation multi-detector row spiral CT.," Radiology 222, 483490 (2002). 10.1148/radiol.2222001802
30. U. J. Schoepf and P. Costello, " CT Angiography for diagnosis of pulmonary embolism: State of the art.," Radiology 230, 329337 (2004). 10.1148/radiol.2302021489 (Pubitemid 38133787)
31. J. P. Ko and D. P. Naidich, " Computer-aided diagnosis and the evaluation of lung disease.," J. Thorac. Imaging 19, 136155 (2004). 10.1097/01.rti.0000135973.65163.69 (Pubitemid 38988975)
32. H. P. Chan, L. M. Hadjiiski, C. Zhou, and B. Sahiner, " Computer-aided diagnosis of lung cancer and pulmonary embolism in computed tomographya review.," Acad. Radiol. 15, 535555 (2008). 10.1016/j.acra.2008. 01.014
33. U. J. Schoepf, A. C. Schneider, M. Das, S. A. Wood, J. I. Cheema, and P. Costello, " Pulmonary embolism: Computer-aided detection at multidetector row spiral computed tomography.," J. Thorac. Imaging 22, 319323 (2007). 10.1097/RTI.0b013e31815842a9 (Pubitemid 350196950)
34. Z. V. Maizlin, P. M. Vos, M. B. Godoy, and P. L. Cooperberg, " Computer-aided detection of pulmonary embolism on CT angiography: Initial experience.," J. Thorac. Imaging 22, 324329 (2007). 10.1097/RTI. 0b013e31815b89ca (Pubitemid 350196951)
35. S. Buhmann, P. Herzog, J. Liang, M. Wolf, M. Salganicoff, C. Kirchhoff, M. Reiser, and C. H. Becker, " Clinical evaluation of a computer-aided diagnosis (CAD) prototype for the detection of pulmonary embolism.," Acad. Radiol. 14, 651658 (2007). 10.1016/j.acra.2007.02.007 (Pubitemid 46898199)
36. C. Engelke, S. Schmidt, A. Bakai, F. Auer, and K. Marten, " Computer-assisted detection of pulmonary embolism: Performance evaluation in consensus with experienced and inexperienced chest radiologists.," Eur. Radiol. 18, 298307 (2007). 10.1007/s00330-007-0770-3
37. C. Zhou, H. P. Chan, S. Patel, P. N. Cascade, B. Sahiner, L. M. Hadjiiski, and E. A. Kazerooni, " Preliminary investigation of computer-aided detection of pulmonary embolism in 3D computed tomographic pulmonary angiography (CTPA) images.," Acad. Radiol. 12, 782792 (2005). 10.1016/j.acra.2005.01.014 (Pubitemid 40791096)
38. C. Zhou, H. P. Chan, B. Sahiner, L. M. Hadjiiski, A. Chughtai, S. Patel, J. Wei, J. Ge, P. N. Cascade, and E. A. Kazerooni, " Automatic multiscale enhancement and hierarchical segmentation of pulmonary vessels in CT pulmonary angiography (CTPA) images for CAD applications.," Med. Phys. 34, 45674577 (2007). 10.1118/1.2804558 (Pubitemid 350197694)
39. H. D. Sostman, P. D. Stein, A. Gottschalk, C. A. Hales, P. K. Woodard, and L. R. Goodman, " Results of the NIH/NHLBI PIOPED II study: Is spiral CT the best and only test for suspected pulmonary embolism?," RSNA Program Book 2004, November 28December 3 (The Radiological Society of North America (RSNA), Chicago, 2004), p. 55.
40. K. R. Castleman, Digital Image Processing (Prentice-Hall, Englewood Cliffs, NJ, 1996).
41. Y. L. Chang and X. Li, " Adaptive image region-growing.," IEEE Trans. Image Process. 3, 868872 (1994). 10.1109/83.336259
42. R. Adams and L. Bischof, " Seeded region growing.," IEEE Trans. Pattern Anal. Mach. Intell. 16, 641647 (1994). 10.1109/34.295913
43. A. Mehnert, " An improved seeded region growing algorithm.," Pattern Recogn. Lett. 18, 10651071 (1997). 10.1016/S0167-8655(97)00131-1 (Pubitemid 28220303)
44. R. C. Gonzalez and R. E. Woods, Digital Image Processing (Addison-Wesley, Reading, 1992).
45. C. Zhou, H. P. Chan, L. M. Hadjiiski, A. Chughtai, S. Patel, P. N. Cascade, B. Sahiner, J. Wei, J. Ge, and E. A. Kazerooni, " Automated detection of pulmonary embolism (PE) in computed tomographic pulmonary angiographic (CTPA) images: Multiscale hierachical expectation-maximization segmentation of vessels and PEs.," Proc. SPIE 6514, 2F12F8 (2007).
46. C. Zhou, " A parallel multi-prescreening method for computerized pulmonary embolism (PE) detection in computed tomographic pulmonary angiographic (CTPA) images.," RSNA Program Book 2007 (The Radiological Society of North America (RSNA), Chicago, 2007).
47. H. P. Chan, B. Sahiner, R. F. Wagner, and N. Petrick, " Classifier design for computer-aided diagnosis in mammography: Effects of finite sample size.," Med. Phys. 24, 10341035 (1997).
48. H. P. Chan, D. Wei, L. T. Niklason, M. A. Helvie, K. L. Lam, M. M. Goodsitt, and D. D. Adler, " Computer-aided classification of malignant/benign microcalcifications in mammography.," Med. Phys. 21, 875 (1994). 10.1118/1.597354 (Pubitemid 24233850)
49. H. P. Chan, D. Wei, K. L. Lam, B. Sahiner, M. A. Helvie, D. D. Adler, and M. M. Goodsitt, " Classification of malignant and benign microcalcifications by texture analysis.," Med. Phys. 22, 938 (1995).
50. T. W. Way, L. M. Hadjiiski, B. Sahiner, H.-P. Chan, P. N. Cascade, E. A. Kazerooni, N. Bogot, and C. Zhou, " Computer-aided diagnosis of pulmonary nodules on CT scans: Segmentation and classification using 3D active contours.," Med. Phys. 33, 23232337 (2006). 10.1118/1.2207129 (Pubitemid 43967219)
51. H. P. Chan, D. Wei, M. A. Helvie, B. Sahiner, D. D. Adler, M. M. Goodsitt, and N. Petrick, " Computer-aided classification of mammographic masses and normal tissue: Linear discriminant analysis in texture feature space.," Phys. Med. Biol. 40, 857876 (1995). 10.1088/0031-9155/40/5/010
52. B. Sahiner, H. P. Chan, N. Petrick, R. F. Wagner, and L. M. Hadjiiski, " Stepwise linear discriminant analysis in computer-aided diagnosis: The effect of finite sample size.," Proc. of SPIEMedical Imaging (SPIE, San Diego, 1999), Vol. 3661, pp. 499510.
53. P. A. Lachenbruch, Discriminant Analysis (Hafner, New York, 1975).
54. M. M. Tatsuoka, Multivariate Analysis, Techniques for Educational and Psychological Research, 2nd ed. (Macmillan, New York, 1988).
55. M. J. Norusis, SPSS for Windows Release 6 Professional Statistics (SPSS Inc., Chicago, 1993).
56. P. Jaccard, " The distribution of the flora in the alpine zone.," New Phytol. 11, 3750 (1912). 10.1111/j.1469-8137.1912.tb05611.x
57. K. Marten and C. Engelke, " Computer-aided detection and automated CT volumetry of pulmonary nodules.," Eur. Radiol. 17, 888901 (2007). 10.1007/s00330-006-0410-3 (Pubitemid 46766870)
58. Y. Masutani, H. MacMahon, and K. Doi, " Computerized detection of pulmonary embolism in spiral CT angiography based on volumetric image analysis.," IEEE Trans. Med. Imaging 21, 15171523 (2002). 10.1109/TMI.2002.806586
59. C. Zhou, L. M. Hadjiiski, S. Patel, H. P. Chan, and B. Sahiner, " Computerized detection of pulmonary embolism in 3D computed tomographic (CT) images.," RSNA 2003, Chicago, November 30December 5 (The Radiological Society of North America (RSNA), Chicago, 2003), p. 51.
60. C. Zhou, H.-P. Chan, S. Patel, P. N. Cascade, B. Sahiner, L. M. Hadjiiski, and E. A. Kazerooni, " Computerized detection of pulmonary embolism in 16-slice computed tomographic pulmonary angiography (CTPA) images.," RSNA 2004, November 28December 3 (The Radiological Society of North America (RSNA), Chicago, 2004), p. 350.