Isolation of Leishmania amastigote protein fractions which induced lymphocyte stimulation and remission of psoriasis

Archives of Dermatological Research

Volumn 301, Issue 6, 2009, Pages 411-427

  O'Daly, Jose Antonio ^a,b,c   Lezama, R ^b   Gleason, J ^a  

^a Astralis LTD   (United States)

^b Center for Psoriasis Research and Treatment   (Venezuela)

^c INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

Author keywords

Amastigote antigens; Blastogenesis; Clinical trial; Delayed type hypersensitivity; HIV+ psoriasis; Psoriasis

Indexed keywords

AS 100; AS 100 2; AS 200; LEISHMANIA VACCINE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; AMASTIGOTE; ARTICLE; CD8+ T LYMPHOCYTE; CHROMATOGRAPHY; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DRUG EFFICACY; DRUG MANUFACTURE; DRUG PURIFICATION; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; FEVER; HEADACHE; HEAT; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; IMMUNIZATION; INJECTION SITE ERYTHEMA; INJECTION SITE PAIN; LEISHMANIA BRAZILIENSIS; LEISHMANIA CHAGASI; MAJOR CLINICAL STUDY; MALE; PATIENT CODING; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ISOLATION; PSORIASIS; PSORIASIS VULGARIS; REMISSION; SIDE EFFECT; SKIN NODULE; SKIN TEST; SOMNOLENCE; T LYMPHOCYTE ACTIVATION; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADULT; AGED; ANIMALS; ANTIGENS, PROTOZOAN; FEMALE; HIV; HIV INFECTIONS; HUMANS; LEISHMANIA; LEISHMANIASIS VACCINES; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; PSORIASIS; REMISSION INDUCTION;

EID: 68149165489     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00403-009-0940-z     Document Type: Article

References (30)

1. O Arican M Aral S Sasmaz P Ciragil 2005 Serum levels of TNF-α, IFN-γ, IL-6, IL-8, IL12, Il-17 and IL-18 in patients with active psoriasis and correlation with disease severity Mediat Inflamm 2005 273 279 10.1155/MI.2005.273
2. MV Balagon PL Tan R Prestidge 2001 Improvement in psoriasis after intradermal administration of delipidated deglycolipidated Mycobacterium vaccae (PVAC) results of an open label trial Clin Exp Dermatol 26 233 241 10.1046/j.1365-2230.2001.00804.x
3. Christophers E, Mrowietz U (2003) Psoriasis. In: Freedberg IM, Eisen AZ, Wolff KK, Austen F, Goldsmith LA, Katz SI (eds) Fitzpatrick's dermatology in general medicine, 6th edn. McGraw-Hill, New York, pp 407-427
4. N Dalbeth S Yeoman JL Dockerty 2004 A randomized placebo controlled trial of delipidated deglycolipidated Mycobacterium vaccae as immunotherapy for psoriatic arthritis Ann Rheum Dis 63 718 722 10.1136/ard.2003.007104
5. M Davies 1983 Phase variations in the modulation of the immune response Immunol Today 4 103 106 10.1016/0167-5699(83)90016-6
6. T Fredriksson U Pettersson 1978 Severe psoriasis-oral therapy with a new retinoid Dermatologica 157 238 244 (Pubitemid 8387357)
7. K Ghoreschi M Rocken 2004 Immune deviation strategies in the therapy of psoriasis Curr Drug Targets Inflamm Allergy 3 193 198 10.2174/1568010043343949
8. JE Gudjonsson A Johnston H Sigmundsdottir 2004 Immunopathogenic mechanisms in psoriasis Clin Exp Immunol 135 1 8 10.1111/j.1365-2249.2004.02310. x
9. IT Harvima G Nilsson MM Suttle 2008 Is there a role for mast cells in psoriasis? Arch Dermatol Res 300 461 478 10.1007/s00403-008-0874-x
10. R Hernadez-Pando L Pavon K Arriaga 1997 Pathogenesis of tuberculosis in mice exposed to low and high doses of an environmental mycobacterial saprophyte before infection Infect Immun 65 3317 3327 (Pubitemid 27342417)
11. SP Jariwala 2007 The role of dendritic cells in the immunopathogenesis of psoriasis Arch Dermatol Res 299 359 366 10.1007/s00403-007-0775-4
12. A Lehrer A Bressanelli V Wachsmann 1998 Immunotherapy with Mycobacterium vaccae in the treatment of psoriasis FEMS Immunol Med Microbiol 21 71 77 10.1111/j.1574-695X.1998.tb01151.x (Pubitemid 28258970)
13. OH Lowry NJ Rosebrough AL Farr 1951 Protein measurement with the folin phenol reagent J Biol Chem 193 265 275
14. SE Mahoney M Duvic BJ Nickoloff 1991 Immunodeficieny virus (HIV) transcripts identified in HIV-related psoriasis and Kaposi's sarcoma lesions J Clin Invest 88 174 185 10.1172/JCI115275
15. E Mallon 2000 Retroviruses and psoriasis Curr Opin Infect Dis 13 103 107 (Pubitemid 30223742)
16. AM Menter GC Krueger SR Feldman 2003 Psoriasis treatment 2003 at the new millennium: position paper on behalf of the authors J Am Acad Dermatol 49 2 S39 S43 10.1016/mjd.2003.545 (Pubitemid 36951245)
17. L Nahary A Tamarkin N Kayam 2008 An investigation of antistreptococcal antibody responses in gutatte psoriasis Arch Dermatol Res 300 441 449 10.1007/s00403-008-0866-x
18. EM Netto D Takahashi M de Oliveira 2006 Phase II randomized, placebo control trial of M. Vaccae-derived protein (PVAC) for the treatment of psoriasis Vaccine 24 5056 5063 10.1016/j.vaccine.2006.03.047
19. JA O'Daly R Lezama PJ Rodriguez 2009 Antigens from Leishmania amastigotes induced clinical remission of psoriasis Arch Dermatol Res 301 1 13 10.1007/s00403-008-0883-9
20. JA O'Daly Z Cabrera 1986 Immunization of hamsters with TLCK-killed parasites induce protection against Leishmania infection Acta Trop 43 225 236
21. K Reich C Garbe V Blaschke 2001 Response of psoriasis to interleukin-10 is associated with suppression of cutaneous type 1 inflammation, downregulation of the epidermal interleukin-8/CXCR2 pathway and normalization of keratinocytes maturation J Invest Dermatol 116 319 329 10.1046/j.1523-1747.2001.01248.x
22. M Seifert W Sterry E Effenberger 2000 The antipsoriatic activity of IL-10 is rather caused by effects on peripheral blood cells than by a direct effect on human keratinocytes Arch Dermatol Res 292 64 72 10.1007/s004030050473
23. LE Serrano JA O'Daly 1987 Protein fraction from Trypanosoma cruzi infected spleen cell supernatants with immunosuppressive activity in vitro Int J Parasitol 17 851 861 10.1016/0020-7519(87)90069-5
24. H Sigmundsdottir B Sigurgeirsson M Toye-Blomberg 1997 Circulating T cells of patients with active psoriasis respond to streptococcal M-peptides sharing sequences with human epidermal keratins Scand J Immunol 45 688 697 10.1046/j.1365-3083.1997.d01-438.x (Pubitemid 27250239)
25. MA Skinner R Prestidge S Yuan 2001 The ability of heat-killed Mycobacterium vaccae to stimulate a cytotoxic T-cell response to an unrelated protein is associated with a 65 kilodalton heat-shock protein Immunology 102 225 233 (Pubitemid 32217515)
26. MA Skinner S Yuan R Prestidge 1997 Immunization with heat-killed Mycobacterium vaccae stimulates CD8+ cytotoxic T cells specific for macrophages infected with Mycobacterium tuberculosis Infect Immun 65 4525 4530 (Pubitemid 27463221)
27. PK Smith RI Krohn GT Hermanson 1985 Measurement of protein using bicinchoninic acid Anal Biochem 150 76 85 10.1016/0003-2697(85)90442-7
28. JE Sokal 1975 Measurement of delayed skin test responses N Engl J Med 293 501 502
29. A Stratis M Pasparakis RA Rupec 2006 Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation J Clin Invest 116 2094 2104 10.1172/JCI27179
30. H Wang T Peters D Kess 2006 Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation J Clin Invest 116 2105 2114 10.1172/JCI27180