'Cannibalism' (cell phagocytosis) does not differentiate reactive renal tubular cells from urothelial carcinoma cells

Cytopathology

Volumn 20, Issue 4, 2009, Pages 224-230

  Ohsaki, H ^a,b   Haba, R ^b   Matsunaga, T ^b   Nakamura, M ^c   Kiyomoto, H ^d   Hirakawa, E ^a  

^a KAGAWA PREFECTURAL UNIVERSITY OF HEALTH SCIENCES   (Japan)

^b KAGAWA UNIVERSITY HOSPITAL   (Japan)

^c National Hospital Organization   (Japan)

^d KAGAWA UNIVERSITY   (Japan)

Author keywords

Cannibalism (cell phagocytosis); Dysmorphic erythrocytes; Reactive renal tubular cells; Renal glomerular disease; Urine cytology; Urothelial carcinoma; Vimentin

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; CARCINOMA CELL; CELL DEATH; CELL DIFFERENTIATION; CELL STRUCTURE; CHILD; CONTROLLED STUDY; FEMALE; GLOMERULONEPHRITIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; KIDNEY TUBULE CELL; MAJOR CLINICAL STUDY; MALE; MICTURITION; PHAGOCYTOSIS; PRIORITY JOURNAL; SCHOOL CHILD; URINE CYTOLOGY; UROGENITAL TRACT TUMOR;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY DISEASES; KIDNEY GLOMERULUS; KIDNEY TUBULES; MALE; MIDDLE AGED; PHAGOCYTOSIS; URINE; UROLOGIC NEOPLASMS; UROTHELIUM; VIMENTIN; YOUNG ADULT;

EID: 68149118962     PISSN: 09565507     EISSN: 13652303     Source Type: Journal    
DOI: 10.1111/j.1365-2303.2009.00655.x     Document Type: Article

References (32)

1. Kojima S, Sekine H, Fukui I, Ohshima H. Clinical significance of "cannibalism" in urinary cytology of bladder cancer. Acta Cytol 1999 42 : 1365 9.
2. Kinjyo M, Soejima T, Watanabe S, Hamano K, Sagiyama K. A cytological and clinical significance of "pair cells" in urine cytology. J Jpn Soc Clin Cytol 1999 38 : 129 35 (in Japanese with an English abstract).
3. Kinjyo M, Soejima T, Watanabe S, Hamano K, Sagiyama K. Morphogenesis of "pair cells" in voided urine cytology: cytological, pathological and immunocytochemical studies. J Jpn Soc Clin Cytol 1999 38 : 221 5 (in Japanese with an English abstract).
4. Gupta K, Dey P. Cell cannibalism: diagnostic marker of malignancy. Diagn Cytopathol 2003 28 : 86 7.
5. Hattori M, Nishino Y, Kakinuma H et al. Cell cannibalism and nucleus-fragmented cells in voided urine: useful parameters for cytologic diagnosis of low-grade urothelial carcinoma. Acta Cytol 2007 51 : 547 51.
6. Takeda S, Unno G. On the inclusion cell in cancer. Gann 1953 44 : 140 2.
7. Bauchwitz MA. The "bird's eye cells": Cannibalism or abnormal division of tumor cells? [Abstract] Acta Cytol 1981 25 : 92.
8. Craig ID, Desrosiers P, Lefcoe MS. Giant-cell carcinoma of the lung. A cytologic study. Acta Cytol 1983 27 : 293 8.
9. Curry JL, Wojcik EM. The effects of the current World Health Organization/International Society of Urologic Pathologists bladder neoplasm classification system on urine cytology results. Cancer 2002 96 : 140 5.
10. Eble JN, Sauter G, Epstein JI, Sesterhenn IA (eds). World Health Organization classification of tumors. In : Pathology and Genetics of Tumors of the Urinary System and Male Genital Organs. Lyon : IARC Press 2004 : pp. 90 149.
11. Ohsaki H, Nakamura M, Nagamachi K, Ogino T. Study on sample preparation for urine cytology. J Jpn Soc Clin Cytol 2005 44 : 215 8 (in Japanese with an English abstract).
12. Brich DF, Fairley KF. Hematuria: glomerular or non-glomerular. Lancet 1979 2 : 845 6.
13. Nguyen GK. Urine cytology in renal glomerular disease and value of G1 cell in the diagnosis of glomerular bleeding. Diagn Cytopathol 2003 29 : 67 73.
14. Robert AC, Robert SB. Microscopic hematuria. N Engl J Med 2003 348 : 2330 8.
15. Thal SM, DeBellis CC, Iverson SA, Schumann GB. Comparison of dysmorphic erythrocytes with other urinary sediment parameters of renal bleeding. Am J Clin Pathol 1986 86 : 784 7.
16. Fassett RG, Horgan BA, Mathew TH. Detection of glomerular bleeding by phase-contrast microscopy. Lancet 1982 1 : 1432 4.
17. Tomita M, Kitamoto Y, Nakayama M, Sato T. A new morphological classification of urinary erythrocyte for differential diagnosis of glomerular hematuria. Clin Nephrol 1992 37 : 84 9.
18. Ohsaki H, Haba R, Matsunaga T et al. Cytomorphologic and immunocytochemical characteristics of reactive renal tubular cells in renal glomerular disease. Acta Cytol 2008 52 : 297 303.
19. Grone HJ, Weber K, Grone E, Helmchen U, Osborn M. Coexpression of keratin and vimentin in damaged and regenerating tubular epithelia of the kidney. Am J Pathol 1987 129 : 1 8.
20. Moll R, Hage C, Thoenes W. Expression of intermediate filament proteins in fetal and adult human kidney: modulations of intermediate filament patterns during development and in damaged tissue. Lab Invest 1991 65 : 74 86.
21. Ward JM, Stevens JL, Konishi N et al. Vimentin metaplasia in renal cortical tubules of preneoplastic, neoplastic, aging, and regenerative lesions of rats and humans. Am J Pathol 1992 141 : 955 64.
22. Abodief WT, Dey P, Al-Hattab O. Cell cannibalism in ductal carcinoma of breast. Cytopathology 2006 17 : 304 5.
23. Brouwer M, de LeyL, Feltkamp CA, Elema J, Jongsma AP. Serum-dependent "cannibalism" and autodestruction in cultures of human small cell carcinoma of the lung. Cancer Res 1984 44 : 2947 51.
24. Tweeddale DN, ed. Urinary Cytology. Boston : Little, Brown and Company 1977 : pp. 91 109.
25. Kluskens LF, Hong HY, Bibb LM. Effects of Therapy on Cytologic Specimens. In : Comprehensive Cytopathology. Bibbo M (ed Philadelphia : W.B. Saunders Company 1977 : pp. 865 85.
26. Gobe GC, Axelsen RA. Genesis of renal tubular atrophy in experimental hydronephrosis in the rat. Role of apoptosis. Lab Invest 1987 56 : 273 81.
27. Wong MG, Suzuki Y, Tanifuji C et al. Peritubular ischemia contributes more to tubular damage than proteinuria in immune-mediated glomerulonephritis. J Am Soc Nephrol 2008 19 : 290 7.
28. Eckardt KU, Rosenberger C, Jürgensen JS, Wiesener MS. Role of hypoxia in the pathogenesis of renal disease. Blood Purif 2003 21 : 253 7.
29. Nangaku M. Hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. Nephron Exp Nephrol 2004 98 : e8 12.
30. Wiegand UK, Corbach S, Prescott AR, Savill J, Spruce BA. The trigger to cell death determines the efficiency with which dying cells are cleared by neighbours. Cell Death Differ 2001 8 : 734 46.
31. Overholtzer M, Mailleux AA, Mouneimne G et al. A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell 2007 131 : 966 79.
32. White E. Entosis: it's a cell-eat-cell world. Cell 2007 131 : 840 2.