CEACAM1 expression in pancreatic endocrine tumors

Applied Immunohistochemistry and Molecular Morphology

Volumn 17, Issue 4, 2009, Pages 286-293

  Serra, Stefano ^a,b   Asa, Sylvia L ^a,b   Bamberger, Ana Maria ^c   Wagener, Christoph ^c   Chetty, Runjan ^a,b  

^a TORONTO GENERAL HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Adhesion molecule; CEACAM1; Neuroendocrine tumor; Pancreas

Indexed keywords

CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; CYTOKERATIN 19; INSULIN; KI 67 ANTIGEN; TUMOR MARKER; VASOACTIVE INTESTINAL POLYPEPTIDE;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER CLASSIFICATION; CANCER INVASION; CONTROLLED STUDY; DISEASE COURSE; ENDOCRINE TUMOR; FEMALE; HUMAN; HUMAN TISSUE; LIVER METASTASIS; LYMPH NODE METASTASIS; LYMPH VESSEL; MAJOR CLINICAL STUDY; MALE; MITOSIS; MULTIPLE ENDOCRINE NEOPLASIA; PANCREAS TUMOR; PRIORITY JOURNAL; TISSUE MICROARRAY; TUMOR CLASSIFICATION; TUMOR NECROSIS; TUMOR VOLUME; VON HIPPEL LINDAU DISEASE; WORLD HEALTH ORGANIZATION;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD; CELL ADHESION MOLECULES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; PANCREATIC NEOPLASMS; RETROSPECTIVE STUDIES;

EID: 68149099998     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/PAI.0b013e318196e13c     Document Type: Article

References (13)

1. Sundberg U, Obrink B. CEACAM1 isoforms with different cytoplasmic domains show different localization, organization and adhesive properties in polarized epithelial cells. J Cell Sci. 2002; 115:1273-1284. (Pubitemid 34272491)
2. Liu W, Wei W, Winer D, et al. CEACAM1 impedes thyroid cancer growth but promotes invasiveness: a putative mechanism for early metastases. Oncogene. 2007;26:2747-2758. (Pubitemid 46663832)
3. Ali A, Serra S, Asa SL, et al. The predictive value of CK19 and CD99 in pancreatic endocrine tumors. Am J Surg Pathol. 2006; 30:1588-1594. (Pubitemid 44808796)
4. Schmitt AM, Rousson V, Anlauf M, et al. WHO 2004 criteria and CK19 are reliable prognostic markers in pancreatic endocrine tumors. Am J Surg Pathol. 2007;31:1677-1682.
5. Drzeniek Z, Lamerz R, Fenger U, et al. Identification of membrane antigens in granulocytes and colonic carcinoma cells by a monoclonal antibody specific for biliary glycoprotein, a member of the carcinoembryonic antigen family. Cancer Lett. 1991;56:173-179.
6. Bamberger AM, Riethdorf L, Nollau P, et al. Dysregulated expression of CD66a (BGP, C-CAM), an adhesion molecule of the CEA family, in endometrial cancer. Am J Pathol. 1998; 152:1401-1406. (Pubitemid 28274997)
7. Busch C, Hanssen TA, Wagener C, et al. Down-regulation of CEACAM1 in human prostate cancer: correlation with loss of cell polarity, increased proliferation rate, and Gleason grade 3 to 4 transition. Hum Pathol. 2002;33:290-298. (Pubitemid 34461462)
8. Kleinerman DI, Troncoso P, Lin SH, et al. Consistent expression of an epithelial cell adhesion molecule (C-CAM) during human prostate development and loss of expression in prostate cancer: implication as a tumor suppressor. Cancer Res. 1995;55:1215-1220.
9. Neumaier M, Paululat S, Chan A, et al. Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas. Proc Natl Acad Sci USA. 1993;90: 10744-10748. (Pubitemid 23347119)
10. Wang L, Lin SH, Wu WG, et al. C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers. Clin Cancer Res. 2000;6:2988-2993. (Pubitemid 30637719)
11. Laack E, Nikbakht H, Peters A, et al. Expression of CEACAM1 in adenocarcinoma of the lung: a factor of independent prognostic significance. J Clin Oncol. 2002;20:4279-4284. (Pubitemid 35266287)
12. Thies A, Moll I, Berger J, et al. CEACAM1 expression in cutaneous malignant melanoma predicts the development of metastatic disease. J Clin Oncol. 2002;20:2530-2536. (Pubitemid 34525740)
13. Ebrahimnejad A, Streichert T, Nollau P, et al. CEACAM1 enhances invasion and migration of melanocytic and melanoma cells. Am J Pathol. 2004;165:1781-1787. (Pubitemid 39435175)