Selenium supplementation in critically ill patients: Pharmacological issues and current evidence;Suplementación con selenio en el paciente crítico: Aspectos farmacológicos y evidencia actual

Nutricion Hospitalaria

Volumn 24, Issue 4, 2009, Pages 429-436

  Manzanares, William ^a   Hardy, G ^b  

^a HOSPITAL DE CLÍNICAS   (Uruguay)

^b MASSEY UNIVERSITY   (New Zealand)

Author keywords

Critically ill; Pharmacokinetics; Posology; Selenium

Indexed keywords

GLUTAMINE; RIVERO; SELENASE; SELENIOUS ACID; SELENITE; SELENIUM; SODIUM SELENITE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; BOLUS INJECTION; CLINICAL TRIAL; CONTINUOUS INFUSION; CRITICAL ILLNESS; DIET SUPPLEMENTATION; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; ENTERIC FEEDING; ENZYME ACTIVITY; HUMAN; INFLAMMATION; INTENSIVE CARE UNIT; MONOTHERAPY; MORTALITY; PARENTERAL NUTRITION; REVIEW; SYSTEMIC DISEASE; UNSPECIFIED SIDE EFFECT;

CRITICAL ILLNESS; DIETARY SUPPLEMENTS; EVIDENCE-BASED MEDICINE; HUMANS; INFLAMMATION; SELENIUM;

EID: 68049138013     PISSN: 02121611     EISSN: 16995198     Source Type: Journal    
DOI: None     Document Type: Review

References (45)

1. Geoghegan M, McAuley D, Eaton S y cols. Selenium in critical illness. Curr Opin Crit Care 2006; 12: 136-141.
2. Rayman MP. The importance of selenium to human health. The Lancet 2000; 356: 233-241
3. Hardy G, Hardy I. Selenium: the Se-XY nutraceutical. Nutrition 2004; 20: 590-593.
4. Berger MM. Can oxidative damage be treated nutritionally? Clin Nutr 2005; 24: 172-183. (Pubitemid 40392800)
5. Dodig S, Cepelak I. The facts and controversy about selenium. Acta Pharm 2004; 54: 261-276.
6. Heyland DK, Dhaliwall R, Suchner U y cols. Antioxidants nutrients: a systematic review of trace elements and vitamins in the critically ill patient. Intensive Care Med 2005; 31: 327-337.
7. Vincent JL, Forceville X. Critically elucidating the role of selenium. Curr Opin Anesthesiol 2008; 21: 148-154.
8. Forceville X, Van Antwerpen P. Selenocompounds and selenium: a biochemical approach to sepsis. In 2008 Yearbook in Intensive Care and Emergency Medicine, Vincent JL (Ed). Springer-Verlag Berlin Heidelberg, pp. 454-466, 2008.
9. Berger MM, Shenkin A. Selenium in intensive care: probably not a magic billet but an important adjuvant therapy. Crit Care Med 2007; 35: 306-307. (Pubitemid 46035719)
10. Burk RF, Hill KE. Selenoprotein P: an extracelular protein with unique physical characteristics and role in selenium homeostasis. Ann Rev Nutr 2005; 25: 2125-2235 (Pubitemid 41209001)
11. Papp LV, Lu J, Holmgren A y cols. From Selenium to selenoproteins. Synthesis, Identity and their role in human health. Antioxid Redox Signal 2007; 9: 775-806. (Pubitemid 46919583)
12. Maehira F, Luyo GA, Miyagy I y cols. Alterations of serum selenium concentration in the acute phase of pathological conditions. Clin Chim Acta 2002; 316: 137-146. (Pubitemid 34028198)
13. Berger MM. Antioxidant micronutrients in major trauma and burns: evidence and practice. Nutr Clin Pract 2006; 21: 438-449. (Pubitemid 44497057)
14. Berger MM, Chiólero R. Antioxidant supplementation in sepsis and systemic inflammatory response syndrome. Crit Care Med 2007; 358 (Supl.): S584-S590. (Pubitemid 47312199)
15. Berger MM, Shenkin A. Selenium in intensive care: probably not a magic bullet but an important adjuvant therapy. Crit Care Med 2007; 35: 306-307. (Pubitemid 46035719)
16. Berger MM & Shenkin A. Update on clinical micronutrient supplementation studies in the critically ill. Curr Opin Clin Nutr Metab Care 2006; 9: 711-716. (Pubitemid 44624618)
17. Angstwurm MWA, Gaertner R. Practicalities of selenium supplementation in critically ill patients. Curr Opin Clin Nutr Metab Care 2006; 9: 233-238. (Pubitemid 44097834)
18. Klein CJ, Nielsen FH, Moser-Veillon PB. Trace element loss in urine and effluent following traumatic injury. JPEN 2008; 32: 129-139.
19. Forceville X, Vitoux D, Gauzit R y cols. Selenium, systemic immune response syndrome, sepsis and outcome in critically ill patients. Crit Care Med 1998; 26: 1536-1544. (Pubitemid 28450362)
20. Sakr Y, Reinhart K, Bloos F y cols. Time course and relationship between plasma selenium concentrations, systemic inflammatory response, sepsis and multiorgan failure. Br J Anaesth 2007; 98: 775-784. (Pubitemid 47072588)
21. Manzanares W, Biestro A, Galusso F y cols. Serum selenium and glutathione peroxidase-3 activity: biomarkers of systemic inflammation in the critically ill.
22. Maehira F, Miyagi I, Eguchi Y. Selenium regulates transcription factor NF-êâ activation during the acute phase reaction. Clin Chem Acta 2003; 334: 163-171. (Pubitemid 36836071)
23. Jeong DW, Yoo MH, Kim TS y cols. Protection of mice from allergen-induced asthma by selenite: prevention of eosinophil infiltration by inhibition of NF-kappa â activation. J Biol Chem 2002; 277: 17871-17876. (Pubitemid 34967596)
24. Stewart MS, Spallholz JE, Neldner KH y cols. Selenium compounds have disparate abilities to impose oxidative stress and induce apoptosis. Free Radic Biol Med 1999; 26: 42-48.
25. Chung YW, Kim TS, Lee SY y cols. Selenite-induced apoptosis of osteoclasts mediated by the mitochondrial pathway. Toxicol Lett 2006; 160: 143-150. (Pubitemid 41578958)
26. Wang Z, Forceville X, Van Antwerpen P y cols. A large bolus, but not a continuous infusion, of sodium selenite improves outcome in peritonitis. Shock 2008. DOI: 10-1097/SHK.0b013e3 18193c35d. Epub ahead of print.
27. Avenell A, Noble DW, Barr J y cols. Selenium supplementation for critically ill adults. Cochrane Database Syst Rev 2006; 2: 1-19.
28. Heyland DK, Dhaliwal R, Drover J y cols. Canadian Clinical Practice Guidelines for nutrition support in mechanically ventilated, critically ill-ventilated patients. Update 2007-2009. http://www.criticalcarenutrition.com. Último acceso: 15 de febrero de 2009.
29. Angstwurm MWA, Engelmann L, Zimmermann T y cols. Selenium in Intensive Care (SIC) study: Results of a prospective, randomized, placebo-controlled, multiple-centre study in patients with severe systemic inflammatory response syndrome, sepsis and septic shock. Crit Care Med 2007; 35: 118-126. (Pubitemid 46035686)
30. Valenta J, Brodska H, Kazda A y cols. Effect of high-dose selenium substitution on selected laboratory parameters and prognosis in critically ill patients. Crit Care 2007; 11 (Supl. 2): P155.
31. Mishra V, Baines M, Perry SE y cols. Effect of selenium supplementation on biochemical markers and outcome in critically ill patients. Clin Nutr 2007; 26: 41-50. (Pubitemid 46179127)
32. Forceville X, Laviolle B, Annane D y cols. Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study. Crit Care 2007; 11: R73. (Pubitemid 47261019)
33. Manzanares W, Torre MH, Biestro A y cols. Pharmacokinetics and pharmacodynamics of high dose selenium in systemic inflammatory response syndrome. Clin Nutr 2008; 3 (Supl. 1): 6-7.
34. Soguel L, Chioléro RL, Ruffieux C y cols. Monitoring the clinical introduction of a glutamine and antioxidant solution in critically ill trauma and burn patients. Nutrition 2008; 24: 1123-1132
35. Berger MM, Soguel L, Shenkin A y cols. Influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery, major trauma and subarachnoid hemorrhage patients. Crit Care 2008; 12: R101.
36. Collier BR, Giladi A, Dosset LA y cols. Impact of high-dose antioxidants on outcomes in acutely injured patients. JPEN J Parent Enteral Nutr 2008; 31: 384-388. (Pubitemid 351875946)
37. Heyland DK, Dhaliwalm R, Day A y cols. Optimizing the dose of glutamine dipeptides and antioxidants in critically ill patients: a phase I dose-finding study. JPEN 2007; 31: 109-118
38. Hardy G, Hardy IJ, Powell-Tuck J. compatibility of sodium selenite with L-alanyl L-glutamine dipeptide in normal saline admixtures. Clin Nutr 2008; (Supl. 1): 161-162.
39. Heyland DK, Dhaliwal R, Day AG y cols. REducing Deaths due to OXidative Stress (The REDOXS Study): rationale and study design for a randomized trial of glutamine and antioxidant supplementation in critically ill patients. Proc Nutr Soc (2006); 65: 250-263. (Pubitemid 46323840)
40. Dhaliwal R, Drover J, Muscedere J y cols. The REDOXS Study: feasibility of pharmaconutrition in critically ill patients. Clin Nutr 2008; (Supl. 1): 41.
41. Andrews PJD, Avenell A, Noble DW y cols. Randomised trial of glutamine and selenium supplemented parenteral nutrition for critically ill patients. SIGNET (Scottish Intensive care Glutamine or seleNium Evaluative Trial). Trials 2007; 8: 25 doi: 10.1186/1745-6215-8-25. (Pubitemid 350154313)
42. Olson OE. Selenium toxicity in animals, with emphasis on man. J Am Coll Toxicol 1986; 5: 45-69. (Pubitemid 16063583)
43. Forceville X, Chancerelle Y, Agay D y cols. At moderately high level, sodium selenium seems to decrease mortality in lipopolysaccharide rat model. Intensive Care Med 2004; 30: S110 (abst).
44. Heyland DK. Selenium supplementation in critically ill patients: can too much of a good thing be a bad thing? Crit Care 2007; 11: 153.
45. Manzanares W, Biestro A, Torre MH y cols. Clinical effects of high dose selenious acid in critically ill patients with systemic inflammation. JPEN J Parenter Enteral Nutr 2009; 33: 186 (Abstr 536-4).