Combined histomorphologic and immunohistochemical phenotype to predict the presence of vascular invasion in colon cancer

Diseases of the Colon and Rectum

Volumn 52, Issue 6, 2009, Pages 1114-1121

  Zlobec, Inti ^a   Höller, Sylvia ^a   Tornillo, Luigi ^a   Terracciano, Luigi ^a   Lugli, Alessandro ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Classification and regression tree analysis; Colon cancer; Immunohistochemistry; Tumor border configuration; Tumor budding; Vascular invasion

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BETA CATENIN; CYCLOOXYGENASE 2; EPHRIN RECEPTOR B2; EPIDERMAL GROWTH FACTOR RECEPTOR; KI 67 ANTIGEN; MAMMALIAN STERILE20 LIKE KINASE; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; PHOSPHOTRANSFERASE; PROTEIN P53; UNCLASSIFIED DRUG; UROKINASE; UROKINASE RECEPTOR; UVOMORULIN; VASCULOTROPIN; RAF PROTEIN; TUMOR MARKER;

ACCURACY; AGED; ANGIOGENESIS; ARTICLE; CANCER GRADING; CANCER INVASION; CANCER SURVIVAL; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; DISEASE CLASSIFICATION; EXPERIMENTAL MODEL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE; MAJOR CLINICAL STUDY; MALE; METASTASIS; MORPHOLOGY; PHENOTYPE; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; TISSUE MICROARRAY; TUMOR VOLUME; VASCULAR DISEASE; CANCER STAGING; CLINICAL TRIAL; COLON TUMOR; LYMPH NODE METASTASIS; METABOLISM; MICROARRAY ANALYSIS; MULTICENTER STUDY; PATHOLOGY; PREDICTION AND FORECASTING; REGRESSION ANALYSIS; SURVIVAL; VASCULAR TUMOR;

AGED; COLONIC NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LYMPHATIC METASTASIS; MALE; MICROARRAY ANALYSIS; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PHENOTYPE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-RAF; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; REGRESSION ANALYSIS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL; VASCULAR NEOPLASMS;

EID: 68049127830     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1007/DCR.0b013e31819eefd9     Document Type: Article

References (30)

1. Liang P, Nakada I, Hong JW, et al. Prognostic significance of immunohistochemically detected blood and lymphatic vessel invasion in colorectal carcinoma: its impact on prognosis. Ann Surg Oncol 2007;14:470-477 (Pubitemid 46175291)
2. Tsai HL, Cheng KI, Lu CY, et al. Prognostic significance of depth of invasion, vascular invasion and numbers of lymph node retrievals in combination for patients with stage II colorectal cancer undergoing radical resection. J Surg Oncol 2008;97:383-387
3. Freedman LS, Macaskill P, Smith AN. Multivariate analysis of prognostic factors for operable rectal cancer. Lancet 1984;2:733-736 (Pubitemid 14037045)
4. Newland RC, Dent OF, Lyttle MN, Chapuis PH, Bokey EL. Pathologic determinants of survival associated with colorectal cancer with lymph node metastases. A multivariate analysis of 579 patients. Cancer 1994;73:2076-2082
5. Compton CC, Fielding LP, Burgart LJ, et al. Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med 2000;124:979-994
6. Sternberg A, Amar M, Alfici R, Groisman G. Conclusions from a study of venous invasion in stage IV colorectal adenocarcinoma. J Clin Pathol 2002;55:17-21. (Pubitemid 34081675)
7. Sternberg A, Mizrahi A, Amar M, Groisman G. Detection of venous invasion in surgical specimens of colorectal carcinoma: the efficacy of various types of tissue blocks. J Clin Pathol 2006;59:207-210 (Pubitemid 43235589)
8. Williams G, Quirke P, Shepherd NA: The Royal College of Pathologists. Dataset for colorectal cancer. 2nd ed. http://www.rcpath.org/resources/pdf/G049- ColorectalDataset-Sep07.pdf. 2007. Accessed December 17, 2007.
9. Blenkinsopp WK, Stewart-Brown S, Blesovsky L, Kearney G, Fielding LP. Histopathology reporting in large bowel cancer. J Clin Pathol 1981;34:509-513 (Pubitemid 11063958)
10. Abdulkader M, Abdulla K, Rakha E, Kaye P. Routine elastic staining assists detection of vascular invasion in colorectal cancer. Histopathology 2006;49:487-492 (Pubitemid 44631621)
11. Sauter G, Simon R, Hillan K. Tissue microarrays in drug discovery. Nat Rev Drug Discov 2003;2:962-972
12. Compton CC. Optimal pathologic staging: defining stage II disease. Clin Cancer Res 2007;13:6862s-70s.
13. Chapuis PH, Dent OF, Fisher R, et al. A multivariate analysis of clinical and pathological variables in prognosis after resection of large bowel cancer. Br J Surg 1985;72:698-702. (Pubitemid 16215165)
14. Mulcahy HE, Skelly MM, Husain A, O'Donoghue DP. Long-term outcome following curative surgery for malignant large bowel obstruction. Br J Surg 1996;83:46-50. (Pubitemid 126423143)
15. Wiggers T, Arends JW, Volovics A. Regression analysis of prognostic factors in colorectal cancer after curative resections. Dis Colon Rectum 1988;31:33-41. (Pubitemid 18045232)
16. Zlobec I, Baker K, Minoo P, Jass JR, Terracciano L, Lugli A. Node-negative colorectal cancer at high risk of distant metastasis identified by combined analysis of lymph node status, vascular invasion, and raf-1 kinase inhibitor protein expression. Clin Cancer Res 2008;14:143-148
17. Benson AB 3rd, Schrag D, Somerfield MR, et al. American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer. J Clin Oncol 2004;22:3408-3419
18. Wolpin BM, Meyerhardt JA, Mamon HJ, Mayer RJ. Adjuvant treatment of colorectal cancer. CA Cancer J Clin 2007;57:168-185
19. Wong RK, Tandan V, De Silva S, Figueredo A. Pre-operative radiotherapy and curative surgery for the management of localized rectal carcinoma. Cochrane Database Syst Rev 2007:CD002102. (Pubitemid 351835429)
20. Breiman L, Friedman J, Olshen R, Stone C. Classification and regression trees. London: Chapman & Hall/CRC, 1984.
21. Hase K, Shatney C, Johnson D, Trollope M, Vierra M. Prognostic value of tumor "budding" in patients with colorectal cancer. Dis Colon Rectum 1993;36:627-635
22. Jass JR, Love SB, Northover JM. A new prognostic classification of rectal cancer. Lancet 1987;1:1303-1306 (Pubitemid 17072200)
23. Zlobec I, Terracciano L, Lugli A. Local recurrence in mismatch repair-proficient colon cancer predicted by an infiltrative tumor border and absence of CD8+ tumor infiltrating lymphocytes. Clin Cancer Res 2008;14:3792-3797
24. Shinto E, Mochizuki H, Ueno H, Matsubara O, Jass JR. A novel classification of tumour budding in colorectal cancer based on the presence of cytoplasmic pseudo-fragments around budding foci. Histopathology 2005;47:25-31. (Pubitemid 40978810)
25. Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T. Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev Cancer 2005;5:744-749 (Pubitemid 41486367)
26. Dass K, Ahmad A, Azmi AS, Sarkar SH, Sarkar FH. Evolving role of uPA/uPAR system in human cancers. Cancer Treat Rev 2008;34:122-136
27. Hiendlmeyer E, Regus S, Wassermann S, et al. Beta-catenin up-regulates the expression of the urokinase plasminogen activator in human colorectal tumors. Cancer Res 2004;64:1209-1214 (Pubitemid 38235582)
28. Fu Z, Smith PC, Zhang L, et al. Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis. J Natl Cancer Inst 2003;95:878-889 (Pubitemid 36833879)
29. Hagan S, Al-Mulla F, Mallon E, et al. Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis. Clin Cancer Res 2005;11:7392-7397 (Pubitemid 41507699)
30. Minoo P, Zlobec I, Baker K, et al. Loss of raf-1 kinase inhibitor protein expression is associated with tumor progression and metastasis in colorectal cancer. Am J Clin Pathol 2007;127:820-827