Clonidine induces calcitonin gene-related peptide expression via nitric oxide pathway in endothelial cells

Peptides

Volumn 30, Issue 9, 2009, Pages 1746-1752

  Zhang, Yi Min ^a,b   Peng, Jun ^a,c   Hu, Chang Ping ^a   Jiang, Qiu Tao ^b   Jiang, Guo Long ^b   Li, Yuan Jian ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b Hunan Yongzhou Food and Drug Administration   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

2 Adrenoceptor; Calcitonin gene related peptide; Clonidine; Nitric oxide

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CALCITONIN GENE RELATED PEPTIDE; CLONIDINE; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; YOHIMBINE;

ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RADIOIMMUNOASSAY; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; RNA ANALYSIS; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; VASODILATATION;

CALCITONIN GENE-RELATED PEPTIDE; CELLS, CULTURED; CLONIDINE; ENDOTHELIAL CELLS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; KINETICS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; RECEPTORS, ADRENERGIC, ALPHA-2; YOHIMBINE;

EID: 68049108231     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2009.06.001     Document Type: Article

References (29)

1. Bell D., and McDermott B.J. Calcitonin gene-related peptide in the cardiovascular system: characterization of receptor populations and their (patho)physiological significance. Pharmacol Rev 48 (1996) 253-288
2. Booth B.P., Nolan T.D., and Fung H.L. Nitroglycerin-inhibited whole blood aggregation is partially mediated by calcitonin gene-related peptide-a neurogenic mechanism. Br J Pharmacol 122 (1997) 577-583
3. Booth B.P., Tabrizi-Fard M.A., and Fung H. Calcitonin gene-related peptide-dependent vascular relaxation of rat aorta. An additional mechanism for nitroglycerin. Biochem Pharmacol 59 (2000) 1603-1609
4. Brain S.D., Williams T.J., Tippins J.R., Morris H.R., and MacIntyre I. Calcitonin gene-related peptide is a potent vasodilator. Nature 313 (1985) 54-56
5. Cai W.Q., Dikranian K., Bodin P., Turmaine M., and Burnstock G. Colocalization of vasoactive substances in the endothelial cells of human umbilical vessels. Cell Tissue Res 274 (1993) 533-538
6. Deng P.Y., Ye F., Zhu H.Q., Cai W.J., Deng H.W., and Li Y.J. An increase in the synthesis and release of calcitonin gene-related peptide in two-kidney, one-clip hypertensive rats. Regul Pept 114 (2003) 175-182
7. Deng P.Y., and Li Y.J. Calcitonin gene-related peptide and hypertension. Peptides 26 (2005) 1676-1685
8. Doi Y., Kudo H., Nishino T., Kayashima K., Kiyonaga H., Nagata T., et al. Synthesis of calcitonin gene-related peptide (CGRP) by rat arterial endothelial cells. Histol Histopathol 16 (2001) 1073-1079
9. Frisk-Holmberg M., Paalzow L., and Wibell L. Relationship between the cardiovascular effects and steady-state kinetics of clonidine in hypertension. Demonstration of a therapeutic window in man. Eur J Clin Pharmacol 26 (1984) 309-313
10. Hastings R.H., and Hua X.Y. Expression of calcitonin gene-related peptide by cultured rat alveolar type II cells. Am J Respir Cell Mol Biol 13 (1995) 563-569
11. Li D., Peng J., Xin H.Y., Luo D., Zhang Y.S., Zhou Z., et al. Calcitonin gene-related peptide-mediated antihypertensive and anti-platelet effects by rutaecarpine in spontaneously hypertensive rats. Peptides 29 (2008) 1781-1788
12. Li D., Chen B.M., Peng J., Zhang Y.S., Li X.H., Yuan Q., et al. Role of anandamide transporter in regulating calcitonin gene-related peptide production and blood pressure in hypertension. J Hypertens 27 (2009) 1224-1232
13. Li W., Hou L., Hua Z., and Wang X. Interleukin-1beta induces beta-calcitonin gene-related peptide secretion in human type II alveolar epithelial cells. Faseb J 18 (2004) 1603-1605
14. Luo D., Zhang Y.W., Peng W.J., Peng J., Chen Q.Q., Li D., et al. Transient receptor potential vanilloid 1-mediated expression and secretion of endothelial cell-derived calcitonin gene-related peptide. Regul Pept 150 (2008) 66-72
15. Marquez-Rodas I., Longo F., Rothlin R.P., and Balfagon G. Pathophysiology and therapeutic possibilities of calcitonin gene-related peptide in hypertension. J Physiol Biochem 62 (2006) 45-56
16. Peng J., and Li Y.J. New insights into nitroglycerin effects and tolerance: role of calcitonin gene-related peptide. Eur J Pharmacol 586 (2008) 9-13
17. Pimentel A.M., Costa C.A., Carvalho L.C., Brandao R.M., Rangel B.M., Tano T., et al. The role of NO-cGMP pathway and potassium channels on the relaxation induced by clonidine in the rat mesenteric arterial bed. Vascul Pharmacol 46 (2007) 353-359
18. Portaluppi F., Trasforini G., Margutti A., Vergnani L., Ambrosio M.R., Rossi R., et al. Circadian rhythm of calcitonin gene-related peptide in uncomplicated essential hypertension. J Hypertens 10 (1992) 1227-1234
19. Shi X.Y., Yang Y., and Zhao Y.T. Plasma calcitonin gene-related peptide (CGRP) level in patients with essential hypertension. Zhonghua Nei Ke Za Zhi 29 (1990) 616-618 39
20. Villalon C.M., Albarran-Juarez J.A., Lozano-Cuenca J., Pertz H.H., Gornemann T., and Centurion D. Pharmacological profile of the clonidine-induced inhibition of vasodepressor sensory outflow in pithed rats: correlation with alpha(2A/2C)-adrenoceptors. Br J Pharmacol 154 (2008) 51-59
21. Wang H., Xing L., Li W., Hou L., Guo J., and Wang X. Production and secretion of calcitonin gene-related peptide from human lymphocytes. J Neuroimmunol 130 (2002) 155-162
22. Wang X., Wu Z.X., Tang Y.M., and Han Q.D. Endotoxin causes release of calcitonin gene-related peptide (CGRP) from the isolated mesenteric arterial bed in rat. Sheng Li Xue Bao 48 (1996) 37-42
23. Wei E.P., Moskowitz M.A., Boccalini P., and Kontos H.A. Calcitonin gene-related peptide mediates nitroglycerin and sodium nitroprusside-induced vasodilation in feline cerebral arterioles. Circ Res 70 (1992) 1313-1319
24. Wing L.M., Reid J.L., Davies D.S., Neill E.A., Tippett P., and Dollery C.T. Pharmacokinetic and concentration-effect relationships of clonidine in essential hypertension. Eur J Clin Pharmacol 12 (1977) 463-469
25. Xing L., Guo J., and Wang X. Induction and expression of beta-calcitonin gene-related peptide in rat T lymphocytes and its significance. J Immunol 165 (2000) 4359-4366
26. Ye F., Deng P.Y., Li D., Luo D., Li N.S., Deng S., et al. Involvement of endothelial cell-derived CGRP in heat stress-induced protection of endothelial function. Vascul Pharmacol 46 (2007) 238-246
27. Zhou Z.H., Deng H.W., and Li Y.J. Involvement of calcitonin gene-related peptide in the development of tolerance to nitroglycerin in the rat. Eur J Pharmacol 427 (2001) 137-141
28. Zhou Z.H., Jiang J.L., Peng J., Deng H.W., and Li Y.J. Reversal of tolerance to nitroglycerin with N-acetylcysteine or captopril: a role of calcitonin gene-related peptide. Eur J Pharmacol 439 (2002) 129-134
29. Zhu Q.M., Lesnick J.D., Jasper J.R., MacLennan S.J., Dillon M.P., Eglen R.M., et al. Cardiovascular effects of rilmenidine, moxonidine and clonidine in conscious wild-type and D79N alpha2A-adrenoceptor transgenic mice. Br J Pharmacol 126 (1999) 1522-1530