NMR and computational studies of stereoisomeric equine estrogen-derived DNA cytidine adducts in oligonucleotide duplexes: Opposite orientations of diastereomeric forms

Biochemistry

Volumn 48, Issue 30, 2009, Pages 7098-7109

  Zhang, Na ^a   Ding, Shuang ^b   Kolbanovskiy, Alexander ^b   Shastry, Anant ^b   Kuzmin, Vladimir A ^b   Bolton, Judy L ^c   Patel, Dinshaw J ^a   Broyde, Suse ^b   Geacintov, Nicholas E ^b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE COMPONENTS; AQUEOUS SOLUTIONS; CELLULAR ENVIRONMENT; COMPLEMENTARY STRAND; COMPUTATIONAL APPROACH; COMPUTATIONAL STUDIES; CYTIDINE; DIASTEREOMERIC; DNA ADDUCTS; DNA DUPLEXES; DNA LESIONS; DOUBLE-HELICAL STRUCTURES; GLYCOSIDIC BOND; HORMONE REPLACEMENT THERAPY; HYDROXYL GROUPS; IN-VITRO; METABOLIC ACTIVATION; MINOR GROOVES; MODIFIED OLIGONUCLEOTIDES; OLIGONUCLEOTIDE DUPLEXES; PREMARIN; WATSON-CRICK PAIRING;

CONFORMATIONS; DNA; GENES; NUCLEAR MAGNETIC RESONANCE; OLIGONUCLEOTIDES; SOLUTIONS; SYNTHESIS (CHEMICAL);

NUCLEIC ACIDS;

4 HYDROXYEQUILENIN; CONJUGATED ESTROGEN; CYTIDINE; DOUBLE STRANDED DNA; DRUG METABOLITE; EQUILENIN; EQUILIN; UNCLASSIFIED DRUG;

ARTICLE; AUTOOXIDATION; DIASTEREOISOMER; DNA ADDUCT; DNA CONFORMATION; DNA DAMAGE; DRUG STRUCTURE; HYBRIDIZATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STEREOISOMERISM;

ANIMALS; BASE SEQUENCE; CYTIDINE; DNA ADDUCTS; DNA DAMAGE; EQUILENIN; EQUILIN; ESTRADIOL CONGENERS; HORSES; HUMANS; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; STEREOISOMERISM;

EQUIDAE;

EID: 68049101976     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9006429     Document Type: Article

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