Chromatic Pupil Responses. Preferential Activation of the Melanopsin-mediated versus Outer Photoreceptor-mediated Pupil Light Reflex

Ophthalmology

Volumn 116, Issue 8, 2009, Pages 1564-1573

  Kardon, Randy ^a,b   Anderson, Susan C ^a,b   Damarjian, Tina G ^a   Grace, Elizabeth M ^a   Stone, Edwin ^a,c   Kawasaki, Aki ^d  

^a UNIVERSITY OF IOWA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

MELANOPSIN;

ADULT; AGED; ARTICLE; BLUE LIGHT; CLINICAL ARTICLE; COLOR BLINDNESS; COLOR VISION; CONTROLLED STUDY; ELECTRORETINOGRAM; EXPERIMENTAL STUDY; HUMAN; HYPOTHESIS; ISCHEMIC OPTIC NEUROPATHY; LIGHT INTENSITY; LUMINANCE; NIGHT VISION; PHOTORECEPTOR; PHOTOSTIMULATION; PHOTOTRANSDUCTION; PRIORITY JOURNAL; PUPIL REFLEX; RED LIGHT; RETINA CONE; RETINA GANGLION CELL; RETINA ROD; SPECTRAL SENSITIVITY; TELEVISION CAMERA; VIDEORECORDING; VISUAL FIELD; VISUAL IMPAIRMENT; VISUAL STIMULATION;

ADULT; AGED; FEMALE; HUMANS; LIGHT; MALE; MIDDLE AGED; OPTIC NEUROPATHY, ISCHEMIC; PHOTOGRAPHY; PHOTORECEPTOR CELLS, VERTEBRATE; PUPIL; REFLEX, PUPILLARY; RETINAL DEGENERATION; RETINAL GANGLION CELLS; RETINAL PHOTORECEPTOR CELL OUTER SEGMENT; ROD OPSINS; YOUNG ADULT;

EID: 67949118778     PISSN: 01616420     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ophtha.2009.02.007     Document Type: Article

References (15)

1. Hattar S., Lucas R.J., Mrosovsky N., et al. Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature 424 (2003) 76-81
2. Hattar S., Liao H.W., Takao M., et al. Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science 295 (2002) 1065-1070
3. Güler A.D., Ecker J.L., Lall G.S., et al. Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision. Nature 453 (2008) 102-105
4. Provencio I., Rodriguez I.R., Jiang G., et al. A novel human opsin in the inner retina. J Neurosci 20 (2000) 600-605
5. Berson D.M., Dunn F.A., and Takao M. Phototransduction by retinal ganglion cells that set the circadian clock. Science 295 (2002) 1070-1073
6. Melyan Z., Tarttelin E.E., Bellingham J., et al. Addition of human melanopsin renders mammalian cells photoresponsive. Nature 433 (2005) 741-745
7. Qiu X., Kumbalasiri T., Carlson S.M., et al. Induction of photosensitivity by heterologous expression of melanopsin. Nature 433 (2005) 745-749
8. Brainard G.C., Hanifin J.P., Greeson J.M., et al. Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor. J Neurosci 21 (2001) 6405-6412
9. Dacey D.M., Liao H.W., Peterson B.B., et al. Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN. Nature 433 (2005) 749-754
10. Gamlin P.D.R., McDougal D.H., Pokorny J., et al. Human and macaque pupil responses driven by melanopsin-containing retinal ganglion cells. Vision Res 47 (2007) 946-954
11. Young R.S., and Kimura E. Pupillary correlates of light-evoked melanopsin activity in humans. Vis Res 48 (2008) 862-871
12. Kawasaki A., and Kardon R.H. Intrinsically photosensitive retinal ganglion cells. J Neuroophthalmol 27 (2007) 195-204
13. Lucas R.J., Hattar S., Takao M., et al. Diminished pupillary light reflex at high irradiances in melanopsin knockout mice. Science 299 (2003) 245-247
14. Gooley J.J., Lu J., Fischer D., and Saper C.B. A broad role for melanopsin in nonvisual photoreception. J Neurosci 23 (2003) 7093-7106
15. Hannibal J., Hindersson P., Ostergaard J., et al. Melanopsin is expressed in PACAP-containing retinal ganglion cells of the human retinohypothalamic tract. Invest Ophthalmol Vis Sci 45 (2004) 4202-4209