Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family

Biochemical and Biophysical Research Communications

Volumn 387, Issue 2, 2009, Pages 399-404

  Schilling, Tobias ^a   Schleithoff, Elisa Schulze ^a   Kairat, Astrid ^a   Melino, Gerry ^b,c   Stremmel, Wolfgang ^a   Oren, Moshe ^d   Krammer, Peter H ^e   Müller, Martina ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

^d WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^e GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Apoptosis; Chemosensitivity; FAS CD95 TNFRSF6 gene; Hepatocellular carcinoma; p53; p63; p73; TNFR superfamily

Indexed keywords

FAS ANTIGEN; ISOPROTEIN; PROTEIN P53; PROTEIN P63; PROTEIN P73; PROTEIN TAP63; PROTEIN TAP73; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; BINDING SITE; CARCINOGENESIS; CD95 GENE; CONTROLLED STUDY; FAS GENE; GENE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTRON; PRIORITY JOURNAL; PROTEIN DOMAIN; TNFRSF6 GENE; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ANTIGENS, CD95; BASE SEQUENCE; BINDING SITES; CELL LINE, TUMOR; DNA-BINDING PROTEINS; HUMANS; INTRONS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 67949101910     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.07.063     Document Type: Article

References (19)

1. Trauth B.C., Klas C., Peters A.J.M., Matzku S., Möller P., Falk W., Debatin K.M., and Krammer P.H. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245 (1989) 301-305
2. Dhein J., Walczak H., Bäumler C., Debatin K.M., and Krammer P.H. Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature 373 (1995) 438-441
3. Croft M. The role of TNF superfamily members in T-cell function and diseases. Nat. Rev. Immunol. 9 (2009) 271-285
4. Wilson N.S., Dixit V., and Ashkenazi A. Death receptor signal transducers: nodes of coordination in immune signaling networks. Nat. Immunol. 10 (2009) 348-355
5. Strasser A., Jost P.J., and Nagata S. The many roles of FAS receptor signaling in the immune system. Immunity 30 (2009) 180-192
6. Müller M., Strand S., Hug H., Heinemann E.M., Walczak H., Hofmann W.J., Stremmel W., Krammer P.H., and Galle P.R. Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. J. Clin. Invest. 99 (1997) 403-413
7. Müller M., Wilder S., Bannasch D., Israeli D., Lehlbach K., Li-Weber M., Friedman S.L., Galle P.R., Stremmel W., Oren M., and Krammer P.H. 53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J. Exp. Med. 188 (1998) 2033-2045
8. Melino G., De Laurenzi V., and Vousden K.H. p73: friend or foe in tumorigenesis. Nat. Rev. Cancer 2 (2002) 605-615
9. Aylon Y., and Oren M. Living with p53, dying of p53. Cell 130 (2007) 597-600
10. Vilgelm A., El Rifai W., and Zaika A. Therapeutic prospects for p73 and p63: rising from the shadow of p53. Drug Resist. Updat. 11 (2008) 152-163
11. Gressner O., Schilling T., Lorenz K., Schulze-Schleithoff E., Koch A., Schulze-Bergkamen H., Lena A.M., Candi E., Terrinoni A., Catani M.V., Oren M., Melino G., Krammer P.H., Stremmel W., and Müller M. TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J. 24 (2005) 2458-2471
12. Müller M., Schilling T., Sayan A.E., Kairat A., Lorenz K., Schulze-Bergkamen H., Oren M., Koch A., Tannapfel A., Stremmel W., Melino G., and Krammer P.H. TAp73/DeltaNp73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma. Cell Death Differ. 12 (2005) 1564-1577
13. Müller M., Schulze-Schleithoff E., Stremmel W., Melino G., Krammer P.H., and Schilling T. One, two, three - p53, p63, p73 and chemosensitivity. Drug Resist. Updat. 9 (2006) 288-306
14. Wada N., Matsumura M., Ohba Y., Kobayashi N., Takizawa T., and Nakanishi Y. Transcription stimulation of the Fas-encoding gene by nuclear factor for interleukin-6 expression upon influenza virus infection. J. Biol. Chem. 270 (1995) 18007-18012
15. Behrmann I., Walczak H., and Krammer P.H. Structure of the human APO-1 gene. Eur. J. Immunol. 24 (1994) 3057-3062
16. He T.C., Zhou S., da Costa L.T., Yu J., Kinzler K.W., and Vogelstein B. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. USA 95 (1998) 2509-2514
17. Li-Weber M., Laur O., Hekele A., Coy J., Walczak H., and Krammer P.H. A regulatory element in the CD95 (APO-1/Fas) ligand promoter is essential for responsiveness to TCR-mediated activation. Eur. J. Immunol. 28 (1998) 2373-2383
18. El-Deiry W.S., Kern S.E., Pietenpol J.A., Kinzler K.W., and Vogelstein B. Definition of a consensus binding site for p53. Nat. Genet. 1 (1992) 45-49
19. Riley T., Sontag E., Chen P., and Levine A. Transcriptional control of human p53-regulated genes. Nat. Rev. Mol. Cell Biol. 9 (2008) 402-412