In vivo pharmacokinetics of ketoprofen after patch application in the Mexican hairless pig

Biopharmaceutics and Drug Disposition

Volumn 30, Issue 4, 2009, Pages 204-208

  Horie, Masafumi ^a   Sekiya, Ichiro ^a   Nakamura, Tomomasa ^a   Tanaka, Hozumi ^b   Maekawa, Kotaro ^c   Nakanishi, Masaru ^c   Muneta, Takeshi ^a   Kobayashi, Eiji ^b  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

^c HISAMITSU PHARMACEUTICAL CO INC   (Japan)

Author keywords

Ketoprofen; Mexican hairless pig; Patch; Pharmacokinetics; Topical application

Indexed keywords

KETOPROFEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; DRUG BLOOD LEVEL; IN VIVO STUDY; MEXICAN HAIRLESS PIG; NONHUMAN; SWINE; TISSUE DISTRIBUTION;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; HUMANS; KETOPROFEN; MEXICO; SKIN ABSORPTION; SWINE; SWINE DISEASES; SWINE, MINIATURE;

EID: 67749113746     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.655     Document Type: Article

References (16)

1. Veys EM. 20 years' experience with ketoprofen. Scand J Rheumatol Suppl 1991; 90: 1-44.
2. Arone S. Long term study of ketoprofen SR in elderly patients. Scand J Rheumatol Suppl 1989; 83: 15-19.
3. Hersh EV, Moore PA, Ross GL. Over-the-counter analgesics and antipyretics: a critical assessment. Clin Ther 2000; 22: 500-548.
4. Mazières B. Topical ketoprofen patch. Drugs R D 2005; 6: 337-344.
5. Fujii M, Yamanouchi S, Hori N, et al. Evaluation of Yucatan micropig skin for use as an in vitro model for skin permeation study. Biol Pharm Bull 1997; 20: 249-254.
6. Garcia MT, da Silva CH, de Oliveira DC, et al. Transdermal delivery of ketoprofen: the influence of drug-dioleylphosphatidylcholine interactions. Pharm Res 2006; 23: 1776-1785.
7. Heo SK, Cho J, Cheon JW, et al. Pharmacokinetics and pharmacodynamics of ketoprofen plasters. Biopharm Drug Dispos 2008; 29: 37-44.
8. Ballerini R, Casini A, Chinol M, et al. Study on the absorption of ketoprofen topically administered in man: comparison between tissue and plasma levels. Int J Clin Pharmacol Res 1986; 6: 69-72.
9. Rolf C, Movin T, Engstrom B, et al. An open, randomized study of ketoprofen in patients in surgery for Achilles or patellar tendinopathy. J Rheumatol 1997; 24: 1595-1598.
10. Rolf C, Engstrom B, Beauchard C, Jacobs LD, Le Liboux A. Intra-articular absorption and distribution of ketoprofen after topical plaster application and oral intake in 100 patients undergoing knee arthroscopy. Rheumatology (Oxford) 1999; 38: 564-567.
11. Cagnie B, Vinck E, Rimbaut S, Vanderstraeten G. Phonophoresis versus topical application of ketoprofen: comparison between tissue and plasma levels. Phys Ther 2003; 83: 707-712.
12. Tanaka H, Kobayashi E. Education and research using experimental pigs in a medical school. J Artif Organs 2006; 9: 136-143.
13. Lavker RM, Dong G, Zheng PS, Murphy GF. Hairless micropig skin. A novel model for studies of cutaneous biology. Am J Pathol 1991; 138: 687-697.
14. Lemus-Flores C, Ulloa-Arvizu R, Ramos-Kuri M, Estrada FJ, Alonso RA. Genetic analysis of Mexican hairless pig populations. J Anim Sci 2001; 79: 3021-3026.
15. Rohatagi S, Barrett JS, McDonald LJ, et al. Selegi-line percutaneous absorption in various species and metabolism by human skin. Pharm Res 1997; 14: 50-55.
16. Shah AK, Wei G, Lanman RC, Bhargava VO, Weir SJ. Percutaneous absorption of ketoprofen from different anatomical sites in man. Pharm Res 1996; 13: 168-172.