Using cases and parents to study multiplicative gene-by-environment interaction

American Journal of Epidemiology

Volumn 170, Issue 3, 2009, Pages 393-400

  Kistner, Emily O ^a   Shi, Min ^b   Weinberg, Clarice R ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b NONE

Author keywords

Case control studies; Epidemiologic methods; Genetic epidemiology; Genetic markers; Genotype environment interaction; Logistic models

Indexed keywords

CYTOCHROME P450 2E1; TOBACCO SMOKE;

DETOXIFICATION; EPIDEMIOLOGY; GENE TRANSFER; GENETIC MARKER; GENOTYPE; HEALTH RISK; PARENT-OFFSPRING INTERACTION; POPULATION STRUCTURE; REGRESSION ANALYSIS;

ARTICLE; BIRTH DEFECT; CASE CONTROL STUDY; CIGARETTE SMOKING; DETOXIFICATION; DISEASE PREDISPOSITION; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; GENETIC EPIDEMIOLOGY; GENETIC SUSCEPTIBILITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MATERNAL BEHAVIOR; PARENT; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ALGORITHMS; ALLELES; CASE-CONTROL STUDIES; CHICAGO; CHILD; CLEFT PALATE; DISEASE SUSCEPTIBILITY; ENVIRONMENTAL EXPOSURE; FEMALE; GENE EXPRESSION REGULATION; GENOTYPE; HUMANS; LOGISTIC MODELS; MALE; MATHEMATICAL COMPUTING; MODELS, GENETIC; PARENTS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; REGRESSION ANALYSIS; RISK FACTORS; SMOKING;

EID: 67749097759     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kwp118     Document Type: Article

References (26)

1. Li H, Romieu I, Sienra-Monge JJ, et al. Genetic polymorphisms in arginase I and II and childhood asthma and atopy. J Allergy Clin Immunol. 2006;117(1):119-126.
2. Wilcox AJ, Weinberg CR, Lie RT. Distinguishing the effects of maternal and offspring genes through studies of "case-parent triads." Am J Epidemiol. 1998;148(9):893-901.
3. Weinberg CR, Wilcox AJ, Lie RT. A log-linear approach to case-parent-triad data: assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting. Am J Hum Genet. 1998;62(4): 969-978.
4. Weinberg CR. Methods for detection of parent-of-origin effects in genetic studies of case-parents triads. Am J Hum Genet. 1999;65(1):229-235.
5. Umbach DM, Weinberg CR. The use of case-parent triads to study joint effects of genotype and exposure. Am J Hum Genet. 2000;66(1):251-261.
6. Schaid DJ. Case-parents design for gene-environment interaction. Genet Epidemiol. 1999;16(3):261-273.
7. Curtis D. Use of siblings as controls in case-control association studies. Ann Hum Genet. 1997;61(pt 4):319-333.
8. Self SG, Longton G, Kopecky KJ, et al. On estimating HLA/ disease association with application to a study of aplastic anemia. Biometrics. 1991;47(1):53-61.
9. Lake SL, Laird NM. Tests of gene-environment interaction for case-parent triads with general environmental exposures. Ann Hum Genet. 2004;68(pt 1):55-64.
10. Vansteelandt S, Demeo DL, Lasky-Su J, et al. Testing and estimating gene-environment interactions in family-based association studies. Biometrics. 2008;64(2):458-467.
11. Gauderman WJ. Sample size requirements for matched case-control studies of gene-environment interaction. Stat Med. 2002;21(1):35-50.
12. Kistner EO, Weinberg CR. Method for using complete and incomplete trios to identify genes related to a quantitative trait. Genet Epidemiol. 2004;27(1):33-42.
13. Dempster AP, Laird NM, Rubin DB. Maximum likelihood from incomplete data via the EM algorithm. J R Stat Soc B. 1977;39(1):1-38.
14. Gauderman WJ. Candidate gene association analysis for a quantitative trait, using parent-offspring trios. Genet Epidemiol. 2003;25(4):327-338.
15. Rothman K, Greenland S. Modern Epidemiology. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
16. Piegorsch WW, Weinberg CR, Taylor JA. Non-hierarchical logistic models and case-only designs for assessing susceptibility in population-based case-control studies. Stat Med. 1994;13(2):153-162.
17. Schaid DJ, Sommer SS. Genotype relative risks: methods for design and analysis of candidate-gene association studies. Am J Hum Genet. 1993;53(5):1114-1126.
18. Wheeler E, Cordell HJ. Quantitative trait association in parent offspring trios: extension of case/pseudocontrol method and comparison of prospective and retrospective approaches. Genet Epidemiol. 2007;31(8):813-833.
19. Little RJ, Rubin DB. Statistical Analysis With Missing Data. New York, NY: John Wiley & Sons, Inc; 1987.
20. Kistner EO, Weinberg CR. A method for identifying genes related to a quantitative trait, incorporating multiple siblings and missing parents. Genet Epidemiol. 2005;29(2): 155-165.
21. Shi M, Christensen K, Weinberg CR, et al. Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants. Am J Hum Genet. 2007;80(1):76-90.
22. Cordell HJ, Barratt BJ, Clayton DG. Case/pseudocontrol analysis in genetic association studies: a unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects. Genet Epidemiol. 2004;26(3):167-185.
23. Chatterjee N, Kalaylioglu Z, Carroll RJ. Exploiting gene-environment independence in family-based case-control studies: increased power for detecting associations, interactions and joint effects. Genet Epidemiol. 2005;28(2):138-156.
24. Lim S, Beyene J, Greenwood CM. Continuous covariates in genetic association studies of case-parent triads: gene and gene-environment interaction effects, population stratification, and power analysis [electronic article]. Stat Appl Genet Mol Biol. 2005;4(1):Article 20.
25. Shi M, Umbach DM, Vermeulen SH, et al. Making the most of case-mother/control-mother studies. Am J Epidemiol. 2008; 168(5):541-547.
26. Kistner EO, Infante-Rivard C, Weinberg CR. A method for using incomplete triads to test maternally mediated genetic effects and parent-of-origin effects in relation to a quantitative trait. Am J Epidemiol. 2006;163(3):255-261.