A method for identifying genes related to a quantitative trait, incorporating multiple siblings and missing parents

Genetic Epidemiology

Volumn 29, Issue 2, 2005, Pages 155-165

  Kistner, Emily O ^a   Weinberg, Clarice R ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Association; Linkage disequilibrium; Missing parents; Multiple siblings; Population admixture

Indexed keywords

ALLELE; ARTICLE; CALCULATION; FAMILY SIZE; GENE IDENTIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC MARKER; GENOTYPE; PARENT; QUANTITATIVE TRAIT; QUANTITATIVE TRAIT LOCUS; SCORING SYSTEM; SIBLING; SIMULATION;

ALLELES; COMPUTER SIMULATION; GENOTYPE; HUMANS; LINKAGE DISEQUILIBRIUM; LOGISTIC MODELS; MODELS, GENETIC; NUCLEAR FAMILY; PARENTS; PEDIGREE; QUANTITATIVE TRAIT LOCI; QUANTITATIVE TRAIT, HERITABLE; SIBLINGS;

EID: 23944505172     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/gepi.20084     Document Type: Article

References (16)

1. Abecasis GR, Cardon LR, Cookson WOC. 2000. A general test of association for quantitative traits in nuclear families. Am J Hum Genet 66:279-292.
2. Allison DB. 1997. Transmission disequilibrium tests for quantitative traits. Am J Hum Genet 60:676-690.
3. Huffman EB, Sen PK, Weinberg CR. 2001. Within-cluster resampling. Biometrika 88:1121-1134.
4. Horvath S, Xu X, Laird NM. 2001. The family based association test method: strategies for studying general genotype-phenotype associations. Eur J Hum Genet 9:301-306.
5. Kistner EO, Weinberg CR. 2004. Method for using complete and incomplete trios to identify genes related to a quantitative trait. Genet Epidemiol 27:33-42.
6. Laird NM, Horvath S, Xu X. 2000. Implementing a unified approach to family-based tests of association. Genet Epidemiol 19(Suppl 1):S36-S42.
7. Lake SL, Blacker D, Laird NM. 2000. Family-based tests of association in the presence of linkage. Am J Hum Genet 67: 1515-1525.
8. Little RJ, Rubin DB. 2002. Statistical analysis with missing data, 2nd ed. New York: John Wiley and Sons.
9. Rabinowitz D, Laird N. 2000. A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Human Hered 50:211-223.
10. Rubin DB. 1987. Multiple imputation for nonresponse in surveys. New York: John Wiley and Sons.
11. Rubin DB, Schenker N. 1991. Multiple imputation in health-care databases: an overview and some applications. Stat Med 10:585-598.
12. Schaid DJ, Sommer SS. 1993. Genotype relative risks: methods for design and analysis of candidate-gene association studies. Am J Hum Genet 53:1114-1126.
13. Spielman RS, McGinnis RE, Ewens WJ. 1993. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52: 506-516.
14. Weinberg CR. 1999. Allowing for missing parents in genetic studies of case-parent triads. Am J Hum Genet 64:1186-1193.
15. Weinberg CR, Wilcox AJ, Lie RT. 1998. A log-linear approach to case-parent-triad data: assessing effects of disease genes that either directly or through maternal effects and that may be subject to parental imprinting. Am J Hum Genet 62:969-978.
16. Williamson JM, Datta S, Satten GA. 2003. Marginal analyses of clustered data when cluster size is informative. Biometrics 59: 36-42.