The history of doping and growth hormone abuse in sport

Growth Hormone and IGF Research

Volumn 19, Issue 4, 2009, Pages 320-326

  Holt, Richard I G ^a   Erotokritou Mulligan, Ioulietta ^a   Sönksen, Peter H ^a  

^a Endocrinology and Metabolism Sub Division   (United Kingdom)

Author keywords

Abuse; GH; IGF I; Insulin; Sport

Indexed keywords

AMPHETAMINE DERIVATIVE; ANABOLIC AGENT; CAFFEINE; CENTRAL STIMULANT AGENT; CORTISONE; GROWTH HORMONE; RECOMBINANT GROWTH HORMONE; STANOZOLOL; TETRAHYDROGESTRINONE;

ARTICLE; ATHLETE; BLOOD ANALYSIS; BODY BUILDING; DOPING; DRUG CONTROL; DRUG LEGISLATION; FATIGUE; GROWTH HORMONE DEFICIENCY; HUMAN; HYPOPITUITARISM; LEGAL ASPECT; MUSCLE STRENGTH; NONHUMAN; PHYSICAL PERFORMANCE; PREVALENCE; PRIORITY JOURNAL; SCREENING TEST; SPORT; URINALYSIS;

ATHLETES; DOPING IN SPORTS; HISTORY, 19TH CENTURY; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; PITUITARY GLAND; PREVALENCE; SPORTS; SUBSTANCE ABUSE DETECTION;

EID: 67749095658     PISSN: 10966374     EISSN: 15322238     Source Type: Journal    
DOI: 10.1016/j.ghir.2009.04.009     Document Type: Article

References (41)

1. Yesalis C.E., and Bahrke M.S. History of doping in sport. In: Bahrke M.S., and Yesalis C.E. (Eds). Performance-Enhancing Substances in Sport and Exercise. first ed. (2002), Human Kinetics, Champaign, IL 1-20
2. Franke W.W., and Berendonk B. Hormonal doping and androgenization of athletes: a secret program of the German Democratic Republic Government. Clin. Chem. 43 7 (1997) 1262-1279
3. Voy R.O., and Deeter K.D. Drugs, Sport, and Politics (1991), Leisure Press, Champaign, IL pp. 227
4. Prokop L. The struggle against doping and its history. J. Sports Med. Phys. Fitness 10 1 (1970) 45-48
5. Donohoe T. Foul Play: Drug Abuse in Sports (1988), Blackwell, Oxford pp. 216
6. Osler T., and Dodd E. Ultra-Marathoning: The Next Challenge (1979), World Publications, Mountain View, CA pp. 219
7. Brown-Sequard C.E. The effects produced in man by subcutaneous injections of a liquid obtained from the testicles of animals. Lancet 2 (1889) 105-107
8. Kearns B., Harkness R., Hobson V., and Smith A. Testosterone pellet implantation in the gelding. J. Am. Vet. Med. Assoc. C/780 (1942) 197-201
9. Laties V.G., and Weiss B. The amphetamine margin in sports. Fed. Proc. 40 12 (1981) 2689-2692
10. Wagner J.C. Enhancement of athletic performance with drugs. An overview. Sports Med. 12 4 (1991) 250-265
11. de Ronde W. Use of androgenic anabolic steroids before and during the Olympic Games: less but not died out. Ned. Tijdschr. Geneeskd. 152 33 (2008) 1820-1824
12. Hoberman J.M. Mortal Engines: The Science of Performance and the Dehumanization of Sport. first ed. (2001), The Blackthorn Press, Pickering pp. 374
13. C.J. Dubin, Commission of Inquiry into the Use of Drugs and Banned Practices Intended to Increase Athletic Performance, Canadian Publishing Center, Ottawa, ON, 1990.
14. Catlin D.H., Fitch K.D., and Ljungqvist A. Medicine and science in the fight against doping in sport. J. Intern. Med. 264 2 (2008) 99-114
15. National Center on Addiction and Substance Abuse, Winning at Any Cost: Doping in Olympic Sport, National Center on Addiction and Substance Abuse, New York, 2000.
16. Li C.H., and Apkoff H. Preparation and properties of growth hormone from human and monkey pituitary glands. Science 124 3235 (1956) 1293-1294
17. Raben M.S. Treatment of a pituitary dwarf with human growth hormone. J. Clin. Endocrinol. Metab. 18 8 (1958) 901-903
18. Duchaine D. Underground Steroid Handbook (1982), OEM, Santa Monica, CA
19. Jorgensen J.O., Pedersen S.A., Thuesen L., Jorgensen J., Ingemann-Hansen T., Skakkebaek N.E., and Christiansen J.S. Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1 8649 (1989) 1221-1225
20. Salomon F., Cuneo R.C., Hesp R., and Sonksen P.H. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. New Engl. J. Med. 321 26 (1989) 1797-1803
21. D. Duchaine, Ultimate muscle mass, Mile High Publishing, Golden Co., 1993, pp. 20.
22. Rennie M.J. Claims for the anabolic effects of growth hormone: a case of the emperor's new clothes?. Brit. J. Sports Med. 37 2 (2003) 100-105
23. Giannoulis M.G., Sonksen P.H., Umpleby M., Breen L., Pentecost C., Whyte M., McMillan C.V., Bradley C., and Martin F.C. The effects of growth hormone and/or testosterone in healthy elderly men: a randomized controlled trial. J. Clin. Endocrinol. Metab. 91 2 (2006) 477-484
24. Graham M.R., Baker J.S., Evans P., Kicman A., Cowan D., Hullin D., Thomas N., and Davies B. Physical effects of short-term recombinant human growth hormone administration in abstinent steroid dependency. Horm. Res. 69 6 (2008) 343-354
25. Mackay, How HGH cheats hit the end of the line, Guardian 28.07.04.
26. Buzzini S.R. Abuse of growth hormone among young athletes. Pediatr. Clin. North Am. 54 4 (2007) 823-843 xiii
27. McHugh C.M., Park R.T., Sonksen P.H., and Holt R.I. Challenges in detecting the abuse of growth hormone in sport. Clin. Chem. 51 9 (2005) 1587-1593
28. S. Abt, Tour de France Steadfast in Ouster of Festina Team, New York Times 19.07.98.
29. World Anti-Doping Agency, The World Anti-Doping Code - The 2008 Prohibited List International Standard, 2008. (accessed 13.05.09).
30. Williams L., and Fainaru-Wada M. Game of Shadows: Barry Bonds, Balco, and the Steroids Scandal That Rocked Professional Sports (2006), Gotham Books, New York pp. 368
31. G.J. Mitchell, Report to the Commissioner of Baseball of an Independent Investigation into The Illegal Use of Steroids and Other Performance Enhancing Substances by Players in Major League Baseball, 2007. .
32. M. Kent, Food and Fitness: A Dictionary of Diet and Exercise, Oxford Reference Online, Oxford University Press, 1997, pp. 384.
33. Csaky T.Z. Doping. J. Sports Med. Phys. Fitness 12 2 (1972) 117-123
34. Powrie J.K., Bassett E.E., Rosen T., Jorgensen J.O., Napoli R., Sacca L., Christiansen J.S., Bengtsson B.A., and Sonksen P.H. Detection of growth hormone abuse in sport. Growth Horm. IGF Res. 17 3 (2007) 220-226
35. GH-2000 group, Final Report to International Olympic Committee and European Union, 1999. (accesses 13.05.09).
36. Wallace J.D., Cuneo R.C., Bidlingmaier M., Lundberg P.A., Carlsson L., Boguszewski C.L., Hay J., Boroujerdi M., Cittadini A., Dall R., Rosen T., and Strasburger C.J. Changes in non-22-kilodalton (kDa) isoforms of growth hormone (GH) after administration of 22-kDa recombinant human GH in trained adult males. J. Clin. Endocrinol. Metab. 86 4 (2001) 1731-1737
37. Bidlingmaier M., Wu Z., and Strasburger C.J. Test method: GH. Baillieres Best. Pract. Res. Clin. Endocrinol. Metab. 14 1 (2000) 99-109
38. Erotokritou-Mulligan I., Bassett E.E., Cowan D., Bartlett C., McHugh C., Sonksen P.H., and Holt R.I. Influence of ethnicity on insulin like growth factor-I and procollagen III peptide in elite athletes and its effect on the ability to detect GH abuse. Clin. Endocrinol. 70 1 (2009) 161-168
39. Nelson A.E., Meinhardt U., Hansen J.L., Walker I.H., Stone G., Howe C.J., Leung K.C., Seibel M.J., Baxter R.C., Handelsman D.J., Kazlauskas R., and Ho K.K. Pharmacodynamics of growth hormone abuse biomarkers and the influence of gender and testosterone: a randomized double-blind placebo-controlled study in young recreational athletes. J. Clin. Endocrinol. Metab. 93 6 (2008) 2213-2222
40. Erotokritou-Mulligan I., Bassett E.E., Kniess A., Sonksen P.H., and Holt R.I. Validation of the growth hormone (GH)-dependent marker method of detecting GH abuse in sport through the use of independent data sets. Growth Horm. IGF Res. 17 5 (2007) 416-423
41. World Anti-Doping Agency, International Standard for Laboratories, 2008. (accessed 13.05.09).