Oncogene functions of FHL2 are independent from NF-κBIα in gastrointestinal cancer

Pathology and Oncology Research

Volumn 15, Issue 1, 2009, Pages 31-36

  Qiao, Liang ^a   Wang, Yan ^a   Pang, Roberta ^a   Wang, Jide ^a   Dai, Yun ^a   Ma, Juan ^a   Gu, Qing ^a   Li, Zesong ^a   Zhang, Yusheng ^a   Zou, Bing ^a   Lan, H Y ^a   Wong, Benjamin C Y ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Colon cancer; FHL2; Gastric cancer; Interaction; NF B; NF BI

Indexed keywords

I KAPPA B KINASE ALPHA; LIM ONLY PROTEIN 2; LIM PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELLULAR DISTRIBUTION; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE FUNCTION; HUMAN; HUMAN CELL; INFLAMMATION; ONCOGENE; PROTEIN LOCALIZATION; STOMACH CANCER; STOMACH CARCINOGENESIS;

BLOTTING, WESTERN; COLONIC NEOPLASMS; HOMEODOMAIN PROTEINS; HUMANS; I-KAPPA B PROTEINS; IMMUNOPRECIPITATION; MUSCLE PROTEINS; NF-KAPPA B; PROTEIN INTERACTION DOMAINS AND MOTIFS; STOMACH NEOPLASMS; SUBCELLULAR FRACTIONS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 67749088536     PISSN: 12194956     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12253-008-9085-1     Document Type: Article

References (26)

1. KK Chan SK Tsui SM Lee SC Luk CC Liew KP Fung MM Waye CY Lee 1998 Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart Gene 210 345 350
2. M Genini P Schwalbe FA Scholl A Remppis MG Mattei BW Schafer 1997 Subtractive cloning and characterization of DRAL, a novel LIM-domain protein down-regulated in rhabdomyosarcoma DNA Cell Biol 16 433 442
3. FA Scholl P McLoughlin E Ehler C de Giovanni BW Schafer 2000 DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis J Cell Biol 151 495 506
4. M Kinoshita T Nakagawa A Shimizu Y Katsuoka 2005 Differently regulated androgen receptor transcriptional complex in prostate cancer compared with normal prostate Int J Urol 12 390 397
5. B Gabriel S Mildenberger CW Weisser E Metzger G Gitsch R Schule JM Muller 2004 Focal adhesion kinase interacts with the transcriptional coactivator FHL2 and both are overexpressed in epithelial ovarian cancer Anticancer Res 24 921 927
6. J Wang Y Yang HH Xia Q Gu MC Lin B Jiang Y Peng G Li X An Y Zhang Z Zhuang Z Zhang HF Kung BC Wong 2007 Suppression of FHL2 expression induces cell differentiation and inhibits gastric and colon carcinogenesis Gastroenterology 132 1066 1076
7. Y Wei CA Renard C Labalette Y Wu L Levy C Neuveut X Prieur M Flajolet S Prigent MA Buendia 2003 Identification of the LIM protein FHL2 as a coactivator of b-catenin J Biol Chem 278 5188 5194
8. J Yan J Zhu H Zhong Q Lu C Huang Q Ye 2003 BRCA1 interacts with FHL2 and enhances FHL2 transactivation function FEBS Lett 553 183 189
9. BT Martin K Kleiber V Wixler M Raab B Zimmer M Kaufmann K Strebhardt 2007 FHL2 regulates cell cycle-dependent and doxorubicin-induced p21Cip1/Waf1 expression in breast cancer cells Cell Cycle 6 1779 1788
10. JM Muller U Isele E Metzger A Rempel M Moser A Pscherer T Breyer C Holubarsch R Buettner R Schule 2000 FHL2, a novel tissue-specific coactivator of the androgen receptor EMBO J 19 359 369
11. GM Fimia D De Cesare P Sassone-Corsi 2000 A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM Mol Cell Biol 20 8613 8622
12. T Samson N Smyth S Janetzky O Wendler JM Muller R Schule H von der Mark K von der Mark V Wixler 2004 The LIM-only proteins FHL2 and FHL3 interact with a- and b-subunits of the muscle a7b1 integrin receptor J Biol Chem 279 28641 28652
13. H Tanahashi T Tabira 2000 Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein Hum Mol Genet 9 2281 2289
14. NH Purcell D Darwis OF Bueno JM Muller R Schule JD Molkentin 2004 Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes Mol Cell Biol 24 1081 1095
15. A Morlon P Sassone-Corsi 2003 The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1 Proc Natl Acad Sci USA 100 3977 3982
16. D Chen W Xu E Bales C Colmenares M Conacci-Sorrell S Ishii E Stavnezer J Campisi DE Fisher A Ben-Ze'ev EE Medrano 2003 SKI activates Wnt/b-catenin signaling in human melanoma Cancer Res 63 6626 6634
17. C Labalette CA Renard C Neuveut MA Buendia Y Wei 2004 Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and b-catenin Mol Cell Biol 24 10689 10702
18. Y Yang H Hou EM Haller SV Nicosia W Bai 2005 Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation EMBO J 24 1021 1032
19. SS Nair Z Guo JM Mueller S Koochekpour Y Qiu RR Tekmal R Schüle HJ Kung R Kumar RK Vadlamudi 2007 Proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor enhances androgen receptor functions through LIM-only coactivator, four-and-a-half LIM-only protein 2 Mol Endocrinol 21 613 624
20. R Stilo A Leonardi L Formisano B Di Jeso P Vito D Liguoro 2002 TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kB activation FEBS Lett 521 165 169
21. K Kleiber K Strebhardt BT Martin 2007 The biological relevance of FHL2 in tumour cells and its role as a putative cancer target Anticancer Res 27 55 61
22. S Bai H Kitaura H Zhao J Chen JM Müller R Schüle 2005 FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner J Clin Invest 115 2742 2751
23. P James J Halladay EA Craig 1996 Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast Genetics 144 1425 1436
24. GR Ding N Honda T Nakahara F Tian M Yoshida H Hirose J Miyakoshi 2003 Radiosensitization by inhibition of IkB-a phosphorylation in human glioma cells Radiat Res 160 232 237
25. ES Lightcap TA McCormack CS Pien V Chau J Adams PJ Elliott 2000 Proteasome inhibition measurements: clinical application Clin Chem 46 673 683
26. J Gao D Pfeifer LJ He F Qiao Z Zhang G Arbman ZL Wang CR Jia J Carstensen XF Sun 2007 Association of NFKBIA polymorphism with colorectal cancer risk and prognosis in Swedish and Chinese populations Scand J Gastroenterol 42 345 350