Antiandrogenic activities of Glycyrrhiza glabra in male rats

International Journal of Andrology

Volumn 32, Issue 4, 2009, Pages 417-422

  Zamansoltani, Farzaneh ^a   Nassiri Asl, Marjan ^a   Sarookhani, Mohammad Reza ^a   Jahani Hashemi, Hassan ^a   Zangivand, Amir Abdollah ^a  

^a QAZVIN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Liquorice; Seminal vesicles; Stereology; Testosterone; Ventral prostate

Indexed keywords

ANDROGEN RECEPTOR; ESTROGEN RECEPTOR; GLYCYRRHIZA GLABRA EXTRACT; TESTOSTERONE;

ANDROGEN THERAPY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; CASTRATION; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; DRUG MEGADOSE; HISTOPATHOLOGY; LEVATOR ANI MUSCLE; LOW DRUG DOSE; MALE; MUSCLE MASS; NONHUMAN; ORGAN WEIGHT; PLANT ROOT; PRIORITY JOURNAL; PROSTATE; PROSTATE EPITHELIUM; PROSTATE VENTRAL LOBE; RAT; SEMINAL VESICLE; STROMA; TESTOSTERONE METABOLISM;

ANDROGEN ANTAGONISTS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; GLYCYRRHIZA; HORMONE REPLACEMENT THERAPY; INJECTIONS, SUBCUTANEOUS; MALE; ORCHIECTOMY; ORGAN SIZE; PLANT EXTRACTS; PROSTATE; RATS; RATS, WISTAR; SEMINAL VESICLES; STROMAL CELLS; TESTOSTERONE;

EID: 67651253094     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2008.00944.x     Document Type: Article

References (27)

1. Allan, G., Lai, M. T., Sbriscia, T., Linton, O., Haynes-Johnson, D., Bhattacharjee, S. et al. (2007) A selective androgen receptor modulator that reduces prostate tumor size and prevents orchidectomy-induced bone loss in rats. Journal of Steroid Biochemistry and Molecular Biology 103, 76 83.
2. Armanini, D., Bonanni, G. Palermo, M. (1999) Reduction of serum testosterone in men by licorice. New England Journal of Medicine 341, 1158.
3. Armanini, D., Fiore, C., Mattarello, M. J., Bielenberg, J. Palermo, M. (2002) History of the endocrine effects of licorice. Experimental and Clinical Endocrinology & Diabetes 110, 257 261.
4. Armanini, D., Bonanni, G., Mattarello, M. J., Fiore, C., Sartorato, P. Palermo, M. (2003) Licorice consumption and serum testosterone in healthy man. Experimental and Clinical Endocrinology & Diabetes 111, 341 343.
5. Armanini, D., Mattarello, M. J., Fiore, C., Bonanni, G., Scaroni, C., Sartorato, P. Palermo, M. (2004) Licorice reduces serum testosterone in healthy women. Steroids 69, 763 766.
6. Asl, M. N. Hosseinzadeh, H. (2008) Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds. Phytotherapy Research 22, 709 724.
7. Bartsch, G., Rittmaster, R. S. Klocker, H. (2002) Dihydrotestosterone and the concept of 5α-reductase inhibition in human benign prostatic hyperplasia. World Journal of Urology 19, 413 425.
8. Dhingra, D., Parle, M. Kulkarni, S. K. (2004) Memory enhancing activity of Glycyrrhiza glabra in mice. Journal of Ethnopharmacology 91, 361 365.
9. Di Mambro, V. M. Fonseca, M. J. (2005) Assays of physical stability and antioxidant activity of a topical formulation added with different plant extract. Journal of Pharmaceutical and Biomedical Analysis 37, 287 295.
10. Haraguchi, H., Ishikawa, H., Mizutani, K., Tamura, Y. Kinoshita, T. (1998) Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata. Bioorganic & Medicinal Chemistry 6, 339 347.
11. Jackson, K. M., Deleon, M., Verret, C. R. Harris, W. B. (2002) Dibenzoylmethane induces cell cycle deregulation in human prostate cancer cells. Cancer Letters 178, 161 165.
12. Jackson, K. M., Frazier, M. C. Harris, W. B. (2007) Suppression of androgen receptor expression by dibenzoylmethane as a therapeutic objective in advanced prostate cancer. Anticancer Research 27, 1483 1488.
13. Johansen, J. A., Breedlove, S. M. Jordan, C. L. (2007) Androgen receptor expression in the levator ani muscle of male mice. Journal of Neuroendocrinology 19, 823 826.
14. Justulin, L. A. Jr., Ureshino, R. P., Zanoni, M. Felisbino, S. L. (2006) Differential proliferative response of the ventral prostate and seminal vesicle to testosterone replacement. Cell Biology International 30, 354 364.
15. Kroes, B. H., Beukelman, C. J., van den Berg, A. J., Wolbink, G. J., van Dijk, H. Labadie, R. P. (1997) Inhibition of human complement by beta-glycyrrhetinic acid. Immunology 90, 115 120.
16. Latif, S. A., Conca, T. J. Morris, D. J. (1990) The effects of the licorice derivative, glycyrrhetinic acid, on hepatic 3 alpha- and 3 beta-hydroxysteroid dehydrogenases and 5 alpha- and 5 beta-reductase pathways of metabolism of aldosterone in male rats. Steroids 55, 52 58.
17. Lu, J., Kim, S. H., Jiang, C., Lee, H. Guo, J. (2007) Oriental herbs as a source of novel anti-androgen and prostate cancer chemopreventive agents. Acta Pharmacologica Sinisa 28, 1365 1372.
18. Lund, T. D., Munson, D. J., Adlercreutz, H., Handa, R. J. Lephart, E. D. (2004) Androgen receptor expression in the rat prostate is down-regulated by dietary phytoestrogens. Reproductive Biology and Endocrinology 2, 5.
19. Morrissey, C., Buser, A., Scolaro, J., O'Sullivan, J., Moquin, A. Tenniswood, M. (2002) Changes in hormone sensitivity in the ventral prostate of aging Sprague-Dawley rats. Journal of Andrology 23, 341 351.
20. Nassiri-Asl, M., Saroukhani, S. Zamansoltani, F. (2007) Anticonvulsant effects of aqueous extract of Glycyrrhiza glabra root in PTZ-induced seizure in mice. International Journal of Pharmacology 3, 432 434.
21. Organization for Economic Cooperation and Development (OECD) (2002) Environment directorate. Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology. OECD Series on Testing and Assessment. OECD, Paris.
22. Parle, M., Dhingra, D. Kulkarni, S. K. (2004) Memory-strengthening activity of Glycyrrhiza glabra in exteroceptive and interoceptive behavioral models. Journal of Medicinal Food 7, 462 466.
23. Prins, G. S. Korach, K. S. (2008) The role of estrogens and estrogen receptors in normal prostate growth and disease. Steroids 73, 233 244.
24. Spignoli, G. (2000) Protective effects of dietary flavonoids on cardiovascular system and circulation. European Bulletin of Drug Research 8, 1 8.
25. Vogel, H. G. (2002) Drug Discovery and Evaluation: Pharmacological Assays, p. 1180. Springer-Verlag, Berlin.
26. Wang, G. S. Han, Z. W. (1993) The protective action of glycyrrhiza flavonoids against carbon tetrachloride hepatotoxicity in mice. Yao Xue Xue Bao 28, 572 576.
27. Williamson, E. M. (2003) Licorice. In : Potter's Cyclopedia of Herbal Medicine (ed. C. W. Daniels pp. 269 271. Saffron Walden, London.