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Volumn 68, Issue 8, 2009, Pages 1367-1368

Dihydroorotate dehydrogenase polymorphism influences the toxicity of leflunomide treatment in patients with rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CYTOCHROME P450 1A2; DIHYDROOROTATE DEHYDROGENASE; GENOMIC DNA; LEFLUNOMIDE;

EID: 67651230875     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2008.099093     Document Type: Letter
Times cited : (34)

References (7)
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    • 0028792355 scopus 로고
    • Safety and effectiveness of leflunomide in the treatment of patientswith active rheumatoid arthritis. Results of a randomized, placebo-controlled, phase II study
    • Mladenovic V, Domljan Z, Rozman B, Jajic I, Mihajlovic D, Dordevic J, et al. Safety and effectiveness of leflunomide in the treatment of patientswith active rheumatoid arthritis. Results of a randomized, placebo-controlled, phase II study. Arthritis Rheum 1995;38:1595- 603.
    • (1995) Arthritis Rheum , vol.38 , pp. 1595-1603
    • Mladenovic, V.1    Domljan, Z.2    Rozman, B.3    Jajic, I.4    Mihajlovic, D.5    Dordevic, J.6
  • 2
    • 0141569613 scopus 로고    scopus 로고
    • In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: Mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes
    • Kalgutkar AS, Nguyen HT, Vaz AD, Doan A, Dalvie DK, McLeod DG, et al. In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes. Drug Metab Dispos 2003;31:1240-50.
    • (2003) Drug Metab Dispos , vol.31 , pp. 1240-1250
    • Kalgutkar, A.S.1    Nguyen, H.T.2    Vaz, A.D.3    Doan, A.4    Dalvie, D.K.5    McLeod, D.G.6
  • 3
    • 50849104253 scopus 로고    scopus 로고
    • Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients
    • Bohanec Grabar P, Rozman B, Tomsic M, Suput D, Logar D, Dolzan V. Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients. Eur J Clin Pharmacol 2008:64:871-6.
    • (2008) Eur J Clin Pharmacol , vol.64 , pp. 871-876
    • Bohanec Grabar, P.1    Rozman, B.2    Tomsic, M.3    Suput, D.4    Logar, D.5    Dolzan, V.6
  • 4
    • 0033764113 scopus 로고    scopus 로고
    • Leflunomide: Mode of action in the treatment of rheumatoid arthritis
    • Breedveld FC, Dayer JM. Leflunomide: mode of action in the treatment of rheumatoid arthritis. Ann Rheum Dis 2000;59:841-9.
    • (2000) Ann Rheum Dis , vol.59 , pp. 841-849
    • Breedveld, F.C.1    Dayer, J.M.2
  • 5
    • 33744491000 scopus 로고    scopus 로고
    • Leflunomide and warfarin interaction: Case report and review of the literature
    • Chonlahan J, Halloran MA, Hammonds A. Leflunomide and warfarin interaction: case report and review of the literature. Pharmacotherapy 2006;26:868-71.
    • (2006) Pharmacotherapy , vol.26 , pp. 868-871
    • Chonlahan, J.1    Halloran, M.A.2    Hammonds, A.3
  • 6
    • 0037039019 scopus 로고    scopus 로고
    • Leflunomide can potentiate the anticoagulant effect of warfarin
    • Lim V, Pande I. Leflunomide can potentiate the anticoagulant effect of warfarin. BMJ 2002;325:1333.
    • (2002) BMJ , vol.325 , pp. 1333
    • Lim, V.1    Pande, I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.