Leflunomide and warfarin interaction: Case report and review of the literature

Pharmacotherapy

Volumn 26, Issue 6 I, 2006, Pages 868-871

  Chonlahan, Jennifer ^a   Halloran, Mary Ann ^b   Hammonds, Amy ^a  

^a UNIVERSITY OF OKLAHOMA   (United States)

^b SANOFI   (France)

Author keywords

Anticoagulation; Drug interaction; INR; International normalized ratio; Leflunomide; Warfarin

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BUSPIRONE; CALCIUM; CYTOCHROME P450 1A2; CYTOCHROME P450 2C9; CYTOCHROME P450 4A; FOLIC ACID; HYDROCHLOROTHIAZIDE; LEFLUNOMIDE; METHOTREXATE; POTASSIUM CHLORIDE; PREDNISONE; PROPAFENONE; RAMIPRIL; SULINDAC; VITAMIN D; WARFARIN;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTICOAGULANT THERAPY; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CASE REPORT; DRUG DOSE REDUCTION; DRUG METABOLISM; ENTEROHEPATIC CIRCULATION; FEMALE; HEART ATRIUM FIBRILLATION; HUMAN; INTERNATIONAL NORMALIZED RATIO; REVIEW; RHEUMATOID ARTHRITIS; THROMBOEMBOLISM;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICOAGULANTS; ARTHRITIS, RHEUMATOID; ATRIAL FIBRILLATION; BLOOD COAGULATION; DRUG INTERACTIONS; FEMALE; HUMANS; INTERNATIONAL NORMALIZED RATIO; ISOXAZOLES; MIDDLE AGED; THROMBOEMBOLISM; WARFARIN;

EID: 33744491000     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.26.6.868     Document Type: Review

References (21)

1. Aventis Pharmaceuticals Inc. Arava (leflunomide) package insert. Kansas City, MO; 2004.
2. Breedveld FC, Dayer JM. Leflunomide: mode of action in the treatment of rheumatoid arthritis. Ann Rheum Dis 2000;59:841-9.
3. Smolen JS, Kalden JR, Scott DL, et al. Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blinded, randomized, multicentre trial. Lancet 1999;353:259-66.
4. Strand V, Cohen S, Schiff M, et al. Treatment of active rheumatoid with leflunomide compared with placebo and methotrexate. Arch Intern Med 1999;159:2542-50.
5. Sharp JT, Strand V, Leung H, Hurley F, Loew-Friedrich I. Treatment with leflunomide slows radiographic progression of rheumatoid arthritis: results from three randomized controlled trials of leflunomide in patients with active rheumatoid arthritis. Arthritis Rheum 2000;43:495-505.
6. Emery P, Breedveld FC, Lemmel EM, et al. A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis. Rheumatology 2000;39:655-65.
7. Cohen S, Cannon GW, Schiff M, et al. Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate. Arthritis Rheum 2001;44(9):1984-92.
8. Olsen NJ, Stein CM. New drugs for rheumatoid arthritis. N Engl J Med 2004;350:2167-79.
9. American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines. Guidelines for the management of rheumatoid arthritis: 2002 update. Arthritis Rheum 2002;46(2):328-46.
10. Hirsh J, Fuster V, Ansell J, Halperin JL. American Heart Association/American College of Cardiology Foundation guide to warfarin therapy. Circulation 2003;107:1692-711.
11. Holbrook AM, Pereira JA, Labiris R, et al. Systematic overview of warfarin and its drug and food interactions. Arch Intern Med 2005;165:1095-106.
12. Rozman B. Clinical pharmacokinetics of leflunomide. Clin Pharmacokinet 2002;41(6):421-30.
13. Lim V, Pande I. Leflunomide can potentiate the anticoagulant effect of warfarin. BMJ 2002;325:1333.
14. Cropp JS, Bussey HI. A review of enzyme induction of warfarin metabolism with recommendations for patient management. Pharmacotherapy 1997;17:917-28.
15. Ross JR, Beeley L. Sulindac, prothrombin time, and anticoagulants [letter]. Lancet 1979;2:1075.
16. Ansell J, Hirsh J, Poller L, Bussey H, Jacobson A, Hylek E. The pharmacology and management of the vitamin K antagonists. Chest 2004;126(suppl 3):204-32.
17. Sievers J, Johansson BW, Nilsson SE. The corticosteroid treatment of acute myocardial infarction. Cardiologia 1964;45:65-76.
18. Brozovic M, Gurd LJ. Prothrombin during warfarin treatment. Br J Haematol 1973;24:579-88.
19. Costedoat-Chalumeau N, Amoura Z, Aymard G, et al. Potentiation of vitamin K antagonists by high-dose intravenous methylprednisolone. Ann Intern Med 2000;132:631-5.
20. Chatterjea JB, Solomon L. Antagonistic effect of ACTH and cortisone on the anticoagulant activity of ethyl biscoumacetate. Br Med J 1954;2:790-2.
21. Menczel J, Breyfuss F. Effect of prednisone on blood coagulation time in patients on dicumarol therapy. J Lab Clin Med 1960;56:14-19.