Management of poor peripheral blood stem cell mobilization: Incidence, predictive factors, alternative strategies and outcome. A retrospective analysis on 2177 patients from three major Italian institutions

Transfusion and Apheresis Science

Volumn 41, Issue 1, 2009, Pages 33-37

  Perseghin, Paolo ^a   Terruzzi, Elisabetta ^b   Dassi, Maria ^a   Baldini, Valentina ^a   Parma, Matteo ^b   Coluccia, Paola ^c   Accorsi, Patrizia ^d   Confalonieri, Giorgio ^a   Tavecchia, Luisa ^a   Verga, Luisa ^b   Ravagnani, Fernando ^c   Iacone, Antonio ^d   Pogliani, E M ^b   Pioltelli, Pietro ^b  

^a Dipartimento di Patologia Clinica   (Italy)

^b SAN GERARDO HOSPITAL   (Italy)

^c Ospedale Civile   (Italy)

^d NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Peripheral blood hematopoietic stem cells; Poor mobilizers; Stem cell collection

Indexed keywords

PLERIXAFOR; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ALLOTRANSPLANTATION; ARTICLE; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; HODGKIN DISEASE; HUMAN; MAJOR CLINICAL STUDY; MULTIPLE MYELOMA; NONHODGKIN LYMPHOMA; PERIPHERAL BLOOD STEM CELL; STEM CELL MOBILIZATION; TREATMENT OUTCOME;

ADULT; ANTIGENS, CD34; FOLLOW-UP STUDIES; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL MOBILIZATION; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; LEUKEMIA, MYELOID, ACUTE; LYMPHOMA, NON-HODGKIN; MULTIPLE MYELOMA; NEOPLASMS; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS;

EID: 67651230396     PISSN: 14730502     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transci.2009.05.011     Document Type: Article

References (28)

1. Krause D.S., Fackler M.J., Civin C.I., and Stratford May W. CD34: structure, biology and clinical utility. Blood 87 (1996) 1-13
2. Gratwohl A., Baldonero H., Frauendorfer K., et al. Results of the EBMT activity survey 2006 on hematopoietic stem cell transplantation: focus on the use of cord blood products. Bone Marrow Transpl 41 (2008) 687-705
3. Gianni A.M. High-dose chemotherapy and autotransplants: a time for guidelines. Ann Oncol 8 (1997) 933-935
4. Tarella C., Di Nicola M., Caracciolo D., et al. High-dose ara-C with autologous peripheral blood progenitor cell support induces a marked progenitor cell mobilization: an indication for patients at risk for low mobilization. Bone Marrow Transpl 30 (2002) 725-732
5. Weaver C.H., Schulman K.A., Wilson-Relyea B., et al. Randomized trial of filgrastim, sargramostim, or sequential sargramostim and filgrastim after myelosuppressive chemotherapy for the harvesting of peripheral blood stem cells. J Clin Oncol 18 (2000) 43-53
6. Montgomery M., and Cottler-Fox M. Mobilization and collection of autologous hematopoietic progenitor/stem cells. Clin Adv Hematol Oncol 5 (2007) 127-136
7. Kessinger A., and Sharp J.G. The whys and hows of hematopoietic progenitor and stem cell mobilization. Bone Marrow Transpl 31 (2003) 319-329
8. Koenigsmann M., Jentsch-Ullrich K., Mohren M., et al. The role of diagnosis in patients failing peripheral blood progenitor cell mobilization. Transfusion 44 (2004) 777-784
9. Pastore D., Specchia G., Mestice A., et al. Good and poor CD34+ cells mobilization in acute leukemia: analysis of factors affecting the yield of progenitor cells. Bone Marrow Transpl 33 (2004) 1083-1087
10. Moog R. Management strategies for poor peripheral blood stem cell mobilization. Transfus Apheresis Sci 38 (2008) 229-236
11. Mendrone Jr. A., Araujo Arrias C., Saboya R., et al. Factors affecting progenitor cell mobilization: an analysis of 307 patients. Transfus Apheresis Sci 39 (2008) 187-192
12. Bensinger W., Appelbaum F., Rowley S., et al. Factors that influence collection and engrafment of autologous peripheral blood stem cells. J Clin Oncol 13 (1995) 2547-2555
13. Yu J., Leisenring W., Bensinger W., et al. The predictive value of white cells or CD34+ cell count in the peripheral blood for timing apheresis and maximizing yield. Transfusion 39 (1999) 442-450
14. Abrahamsen J.F., Stamnesfet S., Liseth K., et al. Large-volume leukapheresis yields more viable CD34+ cells and colony-forming units than normal-volume leukapheresis, especially in patients who mobilize low numbers of CD34+ cells. Transfusion 45 (2005) 248-253
15. Drake M., Ranaghan L., Morris T.C.M., et al. Analysis of the effect of prior therapy on progenitor cell yield: use of a chemotherapy scoring system. Brit J Haematol 98 (1997) 745-749
16. Gandhi M.K., Jestice K., Scott M.A., et al. The minimum CD34 threshold depends on prior chemotherapy in autologous peripheral blood stem cell recipients. Bone Marrow Transpl 23 (1999) 9-13
17. Rick O., Beyer J., Kingreen D., et al. Successful autologous bone marrow rescue in patients who failed peripheral blood stem cell mobilization. Ann Hematol 79 (2000) 681-686
18. Watts M.J., Ings S.J., Flynn M., et al. Remobilization of patients who fail to achieve minimal progenitor threshold at the first attempt is clinically worthwhile. Brit J Haematol 111 (2000) 287-291
19. Calandra G., McCarthy J., McGuick J., et al. AMD3100 plus G-CSF can successfully mobilie CD34+ cells from non-Hodkin lymphoma, Hodgkin's diseases and multiple myeloma patients previously failing mobilization with chemotherapy and/or cytokine treatment: compassionate use data. Bone Marrow Transpl 41 (2008) 331-338
20. Carlo-Stella C., Di Nicola M., Milani R., et al. Use of recombinant human growth hormone (rhGH) plus recombinant human granulocyte colony-stimulating factor (rhG-CSF) for the mobilization and collection of CD34+ cells in poor mobilizers. Blood 103 (2004) 3287-3295
21. Dawson M.A., Schwarer A.P., Muirhead J.L., et al. Successful mobilization of peripheral blood stem cells using recombinant human stem cell factor in heavily pretreated patients who failed a previous attempt with a granulocyte colony-stimulating factor-based regimen. Bone Marrow Transpl 36 (2005) 389-396
22. Pusic I., Jiang S.Y., Landua S., et al. Impact of mobilization and remobilization strategies on achieving sufficient stem cell yields for autologous transplantation. Biol Blood Marrow Transpl 14 (2008) 1045-1056
23. Perseghin P., Gambacorti-Passerini C., Tornaghi L., et al. Peripheral blood progenitor cell collection in chronic myeloid leukemia patients with complete cytogenetic response after treatment with imatinib mesylate. Transfusion 45 (2005) 1214-1220
24. Bensinger W. Stem-cell transplantation for multiple myeloma in the era of novel drugs. J Clin Oncol 26 (2008) 480-492
25. Cavattoni I, Morello E, Oldani E, et al. Outcome of adult AML at first relapse following a risk-oriented strategy: an update of the Northern Italy leucemia group (NILG) experience. Blood 2008; 112 [abstr 4385].
26. Goterris R., Hernandez-Boluda J.C., Teruel A., et al. Impact of different strategies of second-line stem cell harvest on the outcome of autologous transplantation in poor peripheral blood stem cell mobilizers. Bone Marrow Transpl 36 (2005) 847-853
27. Lefrere F., Levy V., Makke J., et al. Successful peripheral blood stem cell harvesting with granulocyte colony-stimulating factor alone after previous mobilization failure. Haematologica 89 (2004) 1532-1533
28. Schwella N., Movassaghi K., Scheding S., et al. Comparison of two leukapheresis programs for computerized collection of blood progenitor cells on a new cell separator. Transfusion 43 (2003) 58-64