Bicarbonate-regulated soluble adenylyl cyclase (sAC) mRNA expression and activity in peripheral chemoreceptors

Advances in Experimental Medicine and Biology

Volumn 648, Issue , 2009, Pages 235-241

  Nunes, A R ^a   Monteiro, E C ^a   Johnson, S M ^a   Gauda, E B ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

cAMP; Carotid body (CB); CO2 HCO3 ; Peripheral arterial chemoreceptors; qRT PCR; Soluble adenylyl cyclase (sAC)

Indexed keywords

ADENYLATE CYCLASE; BICARBONATE; CARBON DIOXIDE; CYCLIC AMP; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; SOLUBLE ADENYLYL CYCLASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; CAROTID BODY; CHEMORECEPTOR; CHEMOSENSITIVITY; CHEMOTRANSDUCTION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; GANGLION; GENE; GENE ACTIVITY; GENE EXPRESSION REGULATION; HOUSEKEEPING GENE; HYPERCAPNIA; HYPOCAPNIA; MALE; MOLECULAR BIOLOGY; NODOSE GANGLION; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL CHEMORECEPTOR; PETROSAL GANGLION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SOLUBLE ADENYLYL CYCLASE GENE; SUPERIOR CERVICAL GANGLION; UPREGULATION; ANIMAL; ARTICLE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; GENETICS; IN VITRO STUDY; METABOLISM; SOLUBILITY; SPRAGUE DAWLEY RAT;

RATTUS;

ADENYLATE CYCLASE; ANIMALS; BICARBONATES; CARBON DIOXIDE; CAROTID BODY; CHEMORECEPTOR CELLS; CYCLIC AMP; GENE EXPRESSION REGULATION, ENZYMOLOGIC; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SOLUBILITY;

EID: 67651207741     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-90-481-2259-2_27     Document Type: Conference Paper

References (15)

1. 2 receptors for the cAMP levels at the carotid body, Adv. Exp. Med. Biol., 536:367-373.
2. Buck, J., Sinclair, M. L., Schapal, L., Cann, M. J., & Levin, L. R. 1999, Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals, Proc. Natl. Acad. Sci. U. S. A., 96:79-84. (Pubitemid 29036056)
3. - on intracellular pH in isolated type-I cells of the neonatal rat carotid body, J. Physiol., 444:703-721.
4. Chen, Y., Cann, M. J., Litvin, T. N., Iourgenko, V., Sinclair, M. L., Levin, L. R., & Buck, J. 2000, Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor, Science, 289:625-628. (Pubitemid 30622067)
5. Gonzalez, C., Almaraz, L., Obeso, A., & Rigual, R. 1994, Carotid body chemoreceptors: from natural stimuli to sensory discharges, Physiol Rev., 74:829-898. (Pubitemid 24328941)
6. Jaiswal, B. S. & Conti, M. 2001, Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase, J. Biol. Chem., 276:31698-31708.
7. Kamenetsky, M., Middelhaufe, S., Bank, E. M., Levin, L. R., Buck, J., & Steegborn, C. 2006, Molecular details of cAMP generation in mammalian cells: a tale of two systems, J. Mol. Biol., 362:623-639. (Pubitemid 44332423)
8. Pastor-Soler, N., Beaulieu, V., Litvin, T. N., Da Silva, N., Chen, Y., Brown, D., Buck, J., Levin, L. R., & Breton, S. 2003, Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling, J. Biol. Chem., 278:49523-49529.
9. Perez-Garcia, M. T., Almaraz, L., & Gonzalez, C. 1990, Effects of different types of stimulation on cyclic AMP content in the rabbit carotid body: functional significance, J. Neurochem., 55:1287-1293.
10. Pfaffl, M. W. 2001, A new mathematical model for relative quantification in real-time RT-PCR, Nucleic Acids Res., 29:e45.
11. Schmid, A., Sutto, Z., Nlend, M. C., Horvath, G., Schmid, N., Buck, J., Levin, L. R., Conner, G. E., Fregien, N., & Salathe, M. 2007, Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP, J. Gen. Physiol, 130:99-109. (Pubitemid 47001074)
12. Sinclair, M. L., Wang, X. Y., Mattia, M., Conti, M., Buck, J., Wolgemuth, D. J., & Levin, L. R. 2000, Specific expression of soluble adenylyl cyclase in male germ cells, Mol. Reprod. Dev., 56:6-11. (Pubitemid 30193857)
13. Sun, X. C., Zhai, C. B., Cui, M., Chen, Y., Levin, L. R., Buck, J., & Bonanno, J. A. 2003, HCO (3) (-)-dependent soluble adenylyl cyclase activates cystic fibrosis transmembrane conductance regulator in corneal endothelium, Am. J. Physiol. Cell Physiol., 284:C1114-C1122. (Pubitemid 36457391)
14. Wang, Y., Lam, C. S., Wu, F., Wang, W., Duan, Y., & Huang, P. 2005, Regulation of CFTR channels by HCO (3) - sensitive soluble adenylyl cyclase in human airway epithelial cells, Am. J. Physiol. Cell Physiol., 289:C1145-C1151. (Pubitemid 41456830)
15. Zippin, J. H., Farrell, J., Huron, D., Kamenetsky, M., Hess, K. C., Fischman, D. A., Levin, L. R., & Buck, J. 2004, Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain, J. Cell Biol., 164:527-534. (Pubitemid 38233314)