Identification of the putative tumor suppressor Nit2 as ω-amidase, an enzyme metabolically linked to glutamine and asparagine transamination

Biochimie

Volumn 91, Issue 9, 2009, Pages 1072-1080

  Krasnikov, Boris F ^a   Chien, Chin Hsiang ^b   Nostramo, Regina ^a   Pinto, John T ^a   Nieves, Edward ^c   Callaway, Myrasol ^c   Sun, Jin ^d,e   Huebner, Kay ^d,e   Cooper, Arthur J L ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d OHIO STATE UNIVERSITY   (United States)

^e OHIO STATE UNIVERSITY   (United States)

Author keywords

Ketoglutaramate; Amidase; Glutamine transaminases; Methionine salvage pathway; Nit2

Indexed keywords

2 OXOGLUTARIC ACID; 4 METHYLTHIO 2 OXOBUTYRIC ACID; AMIDASE; AMINOTRANSFERASE; ASPARAGINE; ESTERASE; GLUTAMINE; GLUTAMINE AMINOTRANSFERASE; METHIONINE; NITRILASE; NITRILASE 1; NITRILASE 2; NITROGEN; OMEGA AMIDASE; OXALOACETIC ACID; SUCCINIC ACID DERIVATIVE; SULFUR; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME METABOLISM; ENZYME SUBSTRATE; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; IN VIVO STUDY; MITOCHONDRIAL RESPIRATION; NITROGEN METABOLISM; NONHUMAN; PROTEIN ANALYSIS; PROTEIN FAMILY; RAT; SEQUENCE HOMOLOGY; TRANSAMINATION; TRANSESTERIFICATION;

AMIDOHYDROLASES; AMINOHYDROLASES; ANIMALS; ASPARAGINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUTAMINE; HUMANS; KETOGLUTARIC ACIDS; KINETICS; LIVER; MICE; MICE, KNOCKOUT; PROTEIN SUBUNITS; RATS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

MAMMALIA; RATTUS;

EID: 67651202156     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2009.07.003     Document Type: Article

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