Adventures in cardiovascular research

Circulation

Volumn 120, Issue 2, 2009, Pages 170-180

  Braunwald, Eugene ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Thrombolysis in Myocardial Infarction Study Group   (United States)

Author keywords

Cardiomyopathy; Heart diseases; Heart failure; Infarction; Ischemia

Indexed keywords

ACETYLSALICYLIC ACID; ATORVASTATIN; CAPTOPRIL; CLOPIDOGREL; DISOPYRAMIDE; PRASUGREL; PRAVASTATIN; PRONETALOL; PROPRANOLOL; STREPTOKINASE; TIROFIBAN; TISSUE PLASMINOGEN ACTIVATOR; VALSARTAN; VERAPAMIL;

AORTA PRESSURE; AORTA STENOSIS; AORTA VALVE REPLACEMENT; AORTIC VALVE REPAIR; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM; CLINICAL TRIAL; HEART DILATATION; HEART FAILURE; HEART INFARCTION; HEART LEFT ATRIUM PRESSURE; HEART LEFT VENTRICLE OUTFLOW TRACT; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEMODYNAMICS; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; MEDICAL PRACTICE; MEDICAL RESEARCH; MEDICAL SCHOOL; MEDICAL SOCIETY; MITRAL ANNULOPLASTY; MITRAL VALVE DISEASE; MITRAL VALVE REGURGITATION; MITRAL VALVE STENOSIS; MUSCLE RESECTION; MYOTOMY; OPERATING ROOM; OXYGEN CONSUMPTION; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; VALVULAR HEART DISEASE; VALVULOPLASTY;

BIOMEDICAL RESEARCH; CARDIOLOGY; CARDIOMYOPATHY, HYPERTROPHIC; HEART FAILURE; HEART VALVE DISEASES; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; MYOCARDIAL ISCHEMIA;

EID: 67651174633     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.109.860965     Document Type: Article

References (65)

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2. Morrow AG, Braunwald E, Haller JA, Sharp EH. Left heart catheterization by the transbronchial route: technic and applications in physiologic and diagnostic investigations. Circulation. 1957;16:1033-1039.
3. Braunwald E, Welch GH Jr, Morrow AG. The effects of acutely increased systemic resistance on the left atrial pressure pulse: a method for the clinical detection of mitral insufficiency. J Clin Invest. 1958;37:35-40.
4. Ross J Jr, Braunwald E, Morrow AG. Left heart catheterization by the transseptal route: a description of the technique and its applications. Circulation. 1960;22:927-934.
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6. Braunwald NS, Cooper T, Morrow AG. Complete replacement of the mitral valve: successful clinical application of a flexible polyurethane prosthesis. J Thorac Cardiovasc Surg. 1960;40:1-11.
7. Braunwald E, Braunwald NS, Ross J Jr, Morrow AG. Effects of mitral-valve replacement on the pulmonary vascular dynamics of patients with pulmonary hypertension. N Engl J Med. 1965;273:509-514.
8. Ross J Jr, Braunwald E. The influence of corrective operation on the natural history of aortic stenosis. Circulation. 1968;37(suppl V):61-67.
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23. Braunwald E, Frahm CJ, Ross J Jr. Studies on Starling's law of the heart, V: left ventricular function in man. J Clin Invest. 1961;40:1882-1890.
24. Sonnenblick EH, Braunwald E, Morrow AG. The contractile properties of human heart muscle: studies on myocardial mechanics of surgically excised papillary muscles. J Clin Invest. 1965;44:966-977.
25. Glick G, Sonnenblick EH, Braunwald E. Myocardial force-velocity relations studies in intact unanesthetized man. J Clin Invest. 1965;44: 978-988.
26. Sonnenblick EH, Braunwald E, Williams JF Jr, Glick G. Effects of exercise on myocardial force-velocity relations in intact unanesthetized man: relative roles of changes in heart rate, sympathetic activity and ventricular dimensions. J Clin Invest. 1965;44:2051-2062.
27. Spann JF Jr, Buccino RA, Sonnenblick EH, Braunwald E. Contractile state of cardiac muscle obtained from cats with experimentally produced ventricular hypertrophy and heart failure. Circ Res. 1967;21:341-354.
28. Folse R, Braunwald E. Determination of fraction of left ventricular volume ejected per beat and of ventricular end-diastolic and residual volumes: experimental and clinical observations with a precordial dilution technique. Circulation. 1962;25:674-685.
29. Elster SK, Braunwald E, Wood HF. A study of C-reactive protein in the serum of patients with congestive heart failure. Am Heart J. 1956;51: 533-541.
30. Anand IS, Latini R, Florea VG, Kuskowski MA, Rector T, Masson S, Signorini S, Mocarelli P, Hester A, Glazer R, Cohn JN; Val-HeFT Investigators. C-reactive protein in heart failure: prognostic value and the effect of valsartan. Circulation. 2005;112:1428-1434.
31. Chidsey CA, Harrison DC, Braunwald E. Augmentation of the plasma norepinephrine response to exercise in patients with congestive heart failure. N Engl J Med. 1962;267:650-654.
32. Chidsey CA, Braunwald E, Morrow AG. Catecholamine excretion and cardiac stores of norepinephrine in congestive heart failure. Am J Med. 1965;39:442-451.
33. Chidsey CA, Kaiser GA, Braunwald E. Biosynthesis of norepinephrine in isolated canine heart. Science. 1963;139:828-829.
34. Braunwald E. The heart as an endocrine organ. Am J Med. 1964;6:1-4.
35. Chidsey CA, Braunwald E, Morrow AG, Mason DT. Myocardial norepinephrine concentration in man: effects of reserpine and of congestive heart failure. N Engl J Med. 1963;269:653-658.
36. Waagstein F, Hjalmarson A, Karnauskas E, Wallentin I. Effect of chronic beta adrenergic receptor blockade in congestive cardiomyopathy. Br Heart J. 1975;37:1022-1036.
37. Pfeffer JM, Pfeffer MA, Braunwald E. Influence of chronic captopril therapy on the infarcted left ventricle of the rat. Circ Res. 1985;57:84-95.
38. Pfeffer JM, Pfeffer MA, Braunwald E. Hemodynamic benefits and prolonged survival with long-term captopril therapy in rats with myocardial infarction and heart failure. Circulation. 1987;75(suppl 1):I-149-I-155.
39. Pfeffer MA, Lamas GA, Vaughan DE, Parisi AF, Braunwald E. Effects of captopril on progressive ventricular dilation after anterior myocardial infarction. N Engl J Med. 1988;319:80-86.
40. Pfeffer MA, Braunwald E, Moye LA, Basta L, Brown EJ Jr, Cuddy TE, Davis BR, Geltman EM, Goldman S, Flaker GC, Klein M, Lamas GA, Packer M, Rouleau, J, Rouleau JL, Rutherford J, Wertheimer JH, Hawkins CM, on behalf of the SAVE Investigators. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: results of the Survival and Ventricular Enlargement Trial. N Engl J Med. 1992;327:669-677.
41. Sarnoff SJ, Braunwald E, Welch GH Jr, Case RB, Stainsby WN, Macruz R. Hemodynamic determinants of oxygen consumption of the heart with special reference to the tension-time index. Am J Physiol. 1958;192: 148-156.
42. Braunwald E, Sarnoff SJ, Case RB, Stainsby WN, Welch GH Jr. Hemodynamic determinants of coronary flow: effect of changes in aortic pressure and cardiac output on the relationship between myocardial oxygen consumption and coronary flow. Am J Physiol. 1958;192: 157-163.
43. Sonnenblick EH, Ross J Jr, Covell JW, Kaiser GA, Braunwald E. Velocity of contraction as a determinant of myocardial oxygen consumption. Am J Physiol. 1965;209:919-927.
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45. Braunwald E, Epstein SE, Glick G, Wechsler A, Braunwald NS. Relief of angina pectoris by electrical stimulation of the carotid sinus. N Engl J Med. 1967;277:1278-1283.
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47. Braunwald E, Covell JW, Maroko PR, Ross J Jr. Effects of drugs and of counterpulsation on myocardial oxygen consumption. Circulation. 1969; 40(suppl):IV-220-IV-228.
48. Maroko PR, Kjekshus JK, Sobel BE, Watanabe T, Covell JW, Ross J Jr, Braunwald E. Factors influencing infarct size following experimental coronary artery occlusion. Circulation. 1971;43:67-82.
49. Maroko PR, Braunwald E. Modification of myocardial infarct size after coronary occlusion. Ann Intern Med. 1973;79:720-733.
50. Chazov EI, Matveeva LS, Mazaev AV, Sargin KE, Sadovskaia GV, Ruda MI. Intracoronary administration of fibrinolysin in acute myocardial infarct. Ter Arkh. 1976;48:8-19.
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52. Markis JE, Malagold M, Parker JA, Silverman KJ, Barry WH, Als AV, Paulin S, Grossman W, Braunwald E. Myocardial salvage after intracoronary thrombolysis with streptokinase in acute myocardial infarction: assessment of intracoronary thallium-201. N Engl J Med. 1981;305: 777-782.
53. The TIMI Study Group. The Thrombolysis in Myocardial Infarction (TIMI) trial. N Engl J Med. 1985;312:932-936.
54. Dalen JE, Gore JM, Braunwald E, Borer J, Goldberg RJ, Passamani ER, Forman S, Knatterud G, the TIMI Investigators. Six and twelve-month follow-up of the phase I Thrombolysis in Myocardial Infarction (TIMI) trial. Am J Cardiol. 1988;62:179-185.
55. Cannon CP, Braunwald E, McCabe CH, Rader DJ, Rouleau JL, Belder R, Joyal SV, Hill KA, Pfeffer MA, Skene AM. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med. 2004;350:1495-1504.
56. Cannon CP, Weintraub WS, Demopoulos LA, Vicari R, Frey MJ, Lakkis N, Neumann F-J, Robertson DH, DeLucca PT, DiBattiste PM, Gibson CM, Braunwald E. Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban. N Eng J Med. 2001;344: 1879-1187.
57. Wiviott SD, Cannon CP, Morrow DA, Ray KK, Pfeffer MA, Braunwald E. Can low-density lipoprotein be too low? The safety and efficacy of achieving very low low-density lipoprotein with intensive statin therapy: a PROVE IT-TIMI 22 substudy. J Am Coll Cardiol. 2005;46:1411-1416.
58. Gurbel PA, Bliden KP, Hiatt BL, O'Connor CM. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation. 2003;107:2908-2913.
59. Wiviott SD, Trenk D, Frelinger AL, O'Donoghue M, Neumann F-J, Michelson AD, Angiolillo DJ, Hod H, Montalescot G, Miller DL, Jakubowski JA, Cairns R, Murphy SA, McCabe CH, Antman EM, Braunwald E. Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention. Circulation. 2007;116:2923-2932.
60. Wiviott SD, Braunwald E, McCabe CH, Montalescot G, Ruzyllo W, Gottlieb S, Neumann F-J, Ardissino D, De Servi S, Murphy SA, Riesmeyer J, Weerakkody G, Gibson CM, Antman EM, for the TRITON-TIMI 38 Investigators. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2007;357:2001-2015.
61. Wiviott SD, Braunwald E, McCabe CH, Horvath I, Keltai M, Herrman JP, Van de Werf F, Downey WE, Scirica BM, Murphy SA, Antman EM, for the TRITON-TIMI 38 Investigators. Intensive oral antiplatelet therapy for reduction of ischemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: a subanalysis of a randomized trial. Lancet. 2008;371:1353-1363.
62. Mega J, Close SL, Wiviott SD, Shen L, Hockett RD, Brandt JT, Walker J, Antman E, Macias W, Braunwald E, Sabatine M. Cytochrome P-450 polymorphisms and response to clopidogrel. N Engl J Med. 2009;360: 354-362.
63. Mega JL, Close SL, Wiviott SD, Shen L, Hockett RD, Brandt JT, Walker JR, Antman EM, Macias WL, Braunwald E, Sabatine MS. Cytochrome P450 genetic polymorphisms and the response to prasugrel. Circulation. 2009;119:2553-2560.
64. Cannon CP, Giugliano RP, Blazing MA, Harrington RA, Peterson JL, McCrary Sisk C, Strony J, Musliner T, McCabe CH, Veltri E, Braunwald E, Califf RM, for the IMPROVE IT Investigators. Design and rationale of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): comparison of ezetimibe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes. Am Heart J. 2008;156:826-832.
65. Marban E, Braunwald E. Training the clinician investigator. Circ Res. 2008;103:771-772.