Apicidin induces apoptosis via cytochrome c-mediated intrinsic pathway in human ovarian cancer cells

Biomolecules and Therapeutics

Volumn 17, Issue 1, 2009, Pages 17-24

  Ahn, Mee Young ^a   Na, Yong Jin ^b   Lee, Jaewon ^a   Lee, Byung Mu ^c   Kim, Hyung Sik ^a  

^a Pusan National University   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

Apicidin; Apoptosis; Histone deacetylase inhibitor; Ovarian cancer

Indexed keywords

APICIDIN; CASPASE 3; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL SUBPOPULATION; CONTROLLED STUDY; CYTOSOL; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; NICK END LABELING; OVARY CANCER; PROTEIN CLEAVAGE; SIGNAL TRANSDUCTION;

EID: 67651170387     PISSN: 19769148     EISSN: None     Source Type: Journal    
DOI: 10.4062/biomolther.2009.17.1.17     Document Type: Article

References (28)

1. Ahn, M. Y., Jung, J. H., Na, Y. J. and Kim, H. S. (2008). A natural histone deacetylase inhibitor, Psammaplin A, induces cell cycle arrest and apoptosis in human endometrial cancer cells. Gynecol. Oncol. 108, 27-33. (Pubitemid 350299431)
2. American Cancer Society. Retrieved September 4, 2007, www.cancer.org.
3. Baradari, V., Huether, A., Höpfner, M., Schuppan, D. and Scherübl, H. (2006). Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal neuroendocrine tumor cells. Endocr. Relat. Cancer 13, 1237-1250. (Pubitemid 46212577)
4. Bokelmann, I. and Mahlknecht, U. (2008). Valproic acid sensitizes chronic lymphocytic leukemia cells to apoptosis and restores the balance between pro- and antiapoptotic proteins. Mol. Med. 14, 20-27. (Pubitemid 351356882)
5. Cheong, J. W., Chong, S. Y., Kim, J. Y., Eom, J. I., Jeung, H. K., Maeng, H. Y., Lee, S. T. and Min, Y. H. (2003). Induction of apoptosis by apicidin, a histone deacetylase inhibitor, via the activation of mitochondria-dependent caspase cascades in human Bcr-Abl-positive leukemia cells. Clin. Cancer Res. 9, 5018-5027.
6. Ding, Z., Yang, X., Pater, A. and Tang, S. C. (2000). Resistance to apoptosis is correlated with the reduced caspase-3 activation and enhanced expression of antiapoptotic proteins in human cervical multidrug-resistant cells. Biochem. Biophys. Res. Commun. 270, 415-420. (Pubitemid 30446850)
7. Eastman, A. (2004). Cell cycle checkpoints and their impact on anticancer therapeutic strategies. J. Cell Biochem. 91, 223-231.
8. Green, D. R. and Reed, J. C. (1998). Mitochondria and apoptosis. Science 281, 1309-1312.
9. Han, J. W., Ahn, S. H., Park, S. H., Wang, S. Y., Bae, G. U., Seo, D. W., Kwon, H. K., Hong, S., Lee, H. Y., Lee, Y. W. and Lee, H. W. (2000). Apicidin, a Histone Deacetylase Inhibitor, Inhibits Proliferation of Tumor Cells via Induction of p21WAF1/Cip1 and Gelsolin. Cancer Res. 60, 6068-6074. (Pubitemid 30839639)
10. Im, J. Y., Park, H., Kang, K. W., Choi, W. S. and Kim, H. S. (2008). Modulation of cell cycles and apoptosis by apicidin in estrogen receptor (ER)-positive and-negative human breast cancer cells. Chem. Biol. Interact. 172, 235-244.
11. Kim, M. S., Son, M. W., Kim, W. B., Park, Y. I. and Moon, A. (2000). Apicidin, an inhibitor of histone deacetylase, prevents H-ras-induced invasive phenotype. Cancer Lett. 157, 23-30.
12. Kim, T. Y., Bang, Y. J. and Robertson, K. D. (2006). Histone deacetylase inhibitors for cancer therapy. Epigenetics 1, 14-23.
13. Kwon, S. H., Ahn, S. H., Kim, Y. K., Bae, G. U., Yoon, J. W., Hong, S., Lee, H. Y., Lee, Y. W., Lee, H. W. and Han, J. W. (2002). Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells. J. Biol. Chem. 277, 2073-2080. (Pubitemid 34968790)
14. Liu, T., Kuljaca, S., Tee, A. and Marshall, G. M. (2006). Histone deacetylase inhibitors: Multi-functional anticancer agents. Cancer Treat. Rev. 32, 157-165.
15. Marks, P. A., Richon, V. M., Miller, T. and Kelly, W. K. (2004). Histone deacetylase inhibitors. Adv. Cancer Res. 91, 137-168.
16. Mogal, A. and Abdulkadir, S. A. (2006). Effects of Histone Deacetylase Inhibitor (HDACi); Trichostatin-A (TSA) on the expression of housekeeping genes. Mol. Cell. Probes 20, 81-86. (Pubitemid 43343719)
17. Naora, H. and Montell, D. J. (2005). Ovarian cancer metastasis: integrating insights from disparate model organisms. J. Nat. Rev. Cancer 5, 355-366. (Pubitemid 40637827)
18. Petrella, A., D'Acunto, C. W., Rodriquez, M., Festa, M., Tosco, A., Bruno, I., Terracciano, S., Taddei, M., Paloma, L. G. and Parente, L. (2008). Effects of FR235222, a novel HDAC inhibitor, in proliferation and apoptosis of human leukaemia cell lines: role of annexin A1. Eur. J. Cancer 44, 740-749.
19. Schepper, S. D., Bruwiere, H. L. N., Verhulst, T., Steller, U., Andries, L., Woutesrs, W., Janicot, M., Artis, J., Heusden, J. V. (2003). Inhibition of histone deacetylases by chlamydocin induces apoptosis and proteasome-mediated degradation of surviving. J. Pharm. Exp. Therap. 304, 881-888. (Pubitemid 36152369)
20. Shankar, S. and Srivastava, R. K. (2008). Histone deacetylase inhibitors: mechanisms and clinical significance in cancer: HDAC inhibitor-induced apoptosis. Adv. Exp. Med. Biol. 615, 261-298.
21. Shao, Y., Gao, Z., Marks, P. A. and Jiang, X. (2004). Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. Proc. Natl. Acad. Sci. U.S.A. 101, 18030-18035. (Pubitemid 40054069)
22. Sobola, H. D., Noymana, E. C., Kazanova, D., Figerb, A., Birkenfelda, S., Shapiroa, L. M., Benamouzig, R. and Arber, N. (2006). Celecoxib leads to G2/M arrest by induction of p21 and down-regulation of cyclin B1 expression in a p53-independent manner. Eur. J. Cancer 42, 422-426. (Pubitemid 43132900)
23. Takai, N., Desmond, J. C., Kumagai, T., Gui, D., Said, J. W., Whittaker, S., Miyakawa, I. and Koeffler, H. P. (2004). Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells. Clin. Cancer Res. 10, 1141-1149. (Pubitemid 38198916)
24. Takai, N. and Narahara, H. (2007). Human endometrial and ovarian cancer cells: histone deacetylase inhibitors exhibit antiproliferative activity, potently induce cell cycle arrest, and stimulate apoptosis. Curr. Med. Chem. 14, 2548-2553. (Pubitemid 350018467)
25. Toh, Y., Yamamoto, M., Endo, K., Ikeda, Y., Baba, H., Kohnoe, S., Yonemasu, H., Hachitanda, Y., Okamura, T. and Sugimachi, K. (2003). Histone H4 acetylation and histone deacetylase 1 expression in esophageal squamous cell carcinoma. Oncol. Rep. 10, 333-338.
26. Ueda, T., Takai, N., Nishida, M., Nasu, K. and Narahara, H. (2007). Apicidin, a novel histone deacetylase inhibitor, has profound anti-growth activity in human endometrial and ovarian cancer cells. Int. J. Mol. Med. 19, 301-308.
27. Wang, X. (2001). The expanding role of mitochondria in apoptosis. Genes Dev. 15, 2922-2933.
28. Xu, W. S., Parmigiani, R. B., Marks, P. A. (2007). Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene 26, 5541-5552. (Pubitemid 47255934)